Effects of lead on ultrastructural charactristics of sinusoidal endothelial cell of fetal rat&#039;s spleen

Heydari , Z; Minaiy Zangi , B; Noori , M; Akbari , M

Volume 55, Issue 5 (1 1997) Tehran Univ Med J 1997, 55(5): 11-16 | Back to browse issues page

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Heydari Z, Minaiy Zangi B, Noori M, Akbari M. Effects of lead on ultrastructural charactristics of sinusoidal endothelial cell of fetal rat's spleen. Tehran Univ Med J 1997; 55 (5) :11-16
URL: http://tumj.tums.ac.ir/article-1-1627-en.html

Effects of lead on ultrastructural charactristics of sinusoidal endothelial cell of fetal rat's spleen

Z Heydari ^*

, B Minaiy Zangi

, M Noori

, M Akbari

Abstract: (54834 Views)

Amount of environmental lead pollution is increased with progression of industry. This pollution is able to damage the living beings in many ways. Blood and Immune systems are more sensitive to toxic effects of lead. 30 female and 6 male rats from Sprague dawley race are chosen by simple random sampling. After copulation and vaginal plug observation, expectant rats are calssified in test and control groups. Since the first day of pregnancy, test group is given a drink containing lead acetate 0.13% in distilled water and control group is given distilled water. After delivery, for ultrastrectural studies, spleen specimens of newborn rats are fixed in glutaraldehyde solution 2% and after processing are studied by T.E.M. Sinusoidal endothelial cell show: morphological changes in mitochondria, appearance of primary & secondary lysosomes and multivesicular bodies and swelling in ER. It seems that these changes are caused by interaction of lead with enzymathic functions or lead accumulation in these cellular organels.

Keywords: Sinusoidal endothlial cell, Fetus, Ultrastructure electronmicroscopy

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