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Background: More than 80 years, the standard treatment of locally advanced cervical
cancer was radiotherapy. However, based on several phase III randomized clinical trials in the past decade, concurrent
cisplatin-based chemoradiotherapy is the current standard of treatment for this
disease. Gemcitabine has potent radiosensitizing properties in preclinical and
clinical trials, so it can be utilized simultaneously with radiation.
Methods: Thirty Women with untreated invasive
squamous-cell carcinoma of the cervix of stage IIB to stage IVA were enrolled in the study in
Radiation Oncology department of Imam Khomeini Hospital in Tehran from
September 2009 to September 2010. Sixty mg/m2 gemcitabine followed by 35 mg/m2 cisplatin were
concurrently administered with radiotherapy to the whole pelvic region on day
one of each treatment week for five weeks One and three months after treatment,
patients underwent a complete physical examination and MRI to determine the response to treatment.
Results: The mean age of the participants was 58.13±11.83 (29-78) years. After 3 months of treatment, 73.3%
had complete and 26.7% had partial response to treatment.
Grade 3 anemia was seen in 10%, grade 3 thrombocytopenia in 3.3% and grade 3
leukopenia in 10% of the patients.
Conclusion: According to the positive results of this study in
stage IIB,
further phase II
and III
clinical trials are suggested to evaluate the role of chemoradiation by
gemcitabine in advanced cervical cancers.
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