Volume 72, Issue 12 (March 2015)
Tehran Univ Med J 2015, 72(12): 847-853 |
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Soboti B, Javadinia S, Noorbaksh S, Asgarian R, Khosravi N, Tabatabaee A. Diagnostic value of the level of interleukins in cerebrospinal fluid in children meningitis . Tehran Univ Med J 2015; 72 (12) :847-853
URL: http://tumj.tums.ac.ir/article-1-6536-en.html
URL: http://tumj.tums.ac.ir/article-1-6536-en.html
Behnam Soboti1 
, Shima Javadinia1 , Samileh Noorbaksh1 , Ramin Asgarian1 , Nastaran Khosravi1 , Azardokht Tabatabaee * 2
, Shima Javadinia1 , Samileh Noorbaksh1 , Ramin Asgarian1 , Nastaran Khosravi1 , Azardokht Tabatabaee * 2
1- Department of Pediatric Infectious Disease, Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Pediatric Infectious Disease, Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. ,azardokht_tabatabaei@yahoo.com
2- Department of Pediatric Infectious Disease, Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. ,
Abstract: (5581 Views)
Background: Cerebrospinal Fluid (CSF) culture for distinction between aseptic and bacterial meningitis can be difficult and long-term, and other diagnostic methods are under studying. This study aimed to assess the diagnostic value for the levels of Interleukin 1 (IL-1), IL-6 and IL-8 of CSF in the children and adolescent with meningitis.
Methods: Fifty-one patient with meningitis between one month and 18 year included in a Cross-Sectional Studies in the Rasul Hospital, Tehran, from 2012 to 2014. All of samples underwent aspiration of CSF. The routine tests performed that include culture coloring and biochemical of CSF. The concentrations of IL-1, IL-6 and IL-8 were determined by Enzyme-linked immunosorbant assay (ELISA) method and all of data were analyzed.
Results: Frequency of bacterial and aseptic meningitis was equal (49%). 64.7% of samples were boys and gender had not different between two bacterial and aseptic group (P=0.7). Mean (±SD) of the age in total was 358.46±858.40, and bacterial group had a higher mean of age than aseptic group (P=0.047). The level of IL-1 was 10.87±37.04 pg/ml in bacterial and 0.55±1.64 pg/ml in aseptic group, that had not different (P=0.168). The level of IL-6 was 90.51±139.3 pg/ml in bacterial and 21.36±67.84 pg/ml in aseptic group, that had significant different (P=0.030). The level of IL-8 was 365.40±765.52 pg/ml in bacterial and 50.66±59.34 pg/ml in aseptic group, that had significant different (P=0.047). Diagnostic value of IL-1 was noted in the 80.77% of bacterial and 68.00% of aseptic group that had not different (P=0.349). Diagnostic value of IL-6 was noted in the 53.85% of bacterial and 64.00% of aseptic group that had not different (P=0.572). Diagnostic value of IL-8 was noted in the 80.77% of bacterial and 28.00% of aseptic group that had significant different (P=0.000). There was not different between two group of CSF variables include coloring degree, WBC and RBC index, glucose and protein.
Conclusion: Although the concentration of IL-6 and IL-8 was higher in bacterial meningitis than in aseptic patients, only IL-8 had suitable diagnostic value for distinction between different types of meningitis.
Keywords: adolescent, aseptic, bacterial meningitis, cerebrospinal fluid, child, cross-sectional studies, diagnostic value, interleukins, meningitis
Type of Study: Original Article |
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