Showing 4 results for Aghaie
Saadat Niaki A, Momenzadeh S, Mohammadinasab H, Ghahramani M, Nayebaghaie H, Ommi D,
Volume 69, Issue 6 (6 2011)
Abstract
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Background: Shoulder pain is a common complication of cerebrovascular accidents. This study was conducted to assess the effects
of local injections of bupivacaine and triamcinolone acetate on shoulder joint pain
and on restricted range of motion following brain events.
Methods: This single-blind clinical trial study included 35 patients
with chronic shoulder pain (the controls) and 35 patients
with chronic shoulder pain due to brain events (the case group). The study was
done at Imam Hossein Hospital & Gandhi Day Clinic
during the year 2008-2010. The patients in the
two groups received bupivacaine and triamcinolone acetate for subacromial bursa
injection and suprascapular nerve block by following the protocol described by
Dangoisse et al. The patients were followed up for 12
weeks and they were evaluated for pain and range of motion 1,
6, and 12 weeks after the
injections.
Results: The mean age of the patients was 60.9±9.07
years. Statistically significant improvements in pain score (P=0.001)
and shoulder joint range of motion (P=0.001)
were observed in patients with chronic shoulder pain versus patients with brain
events 12 weeks after
suprascapulare nerve block and subacromial bours injections by bupivacaine and triamcinolone acetate.
Conclusion: Suprascapular
nerve block and subacromial bursa injections of bupivacaine and triamcinolone
acetate is a safe and efficacious treatment for the treatment of chronic shoulder
pain and restricted range of motion but it is not efficacious or of significant
value for the treatment of shoulder pain in patients with brain events.
Baradaran B, Tartibian B, Baghaiee B, Monfaredan A,
Volume 70, Issue 4 (5 2012)
Abstract
Background: Inflammatory enzymes and free radicals are important factors affecting the immune system. However, there seems to be no detailed information about the extent to which these factors can affect superoxide dismutase 1 gene expression in female athletes, especially in incremental exercises. Therefore, the aim of the present study was to investigate the correlation between superoxide dismutase 1 gene expression with lactate dehydrogenase (LDH) and free radicals in female athletes after an incremental intensity exercise.
Methods: Fifteen 22-24 year old female athletes from Urmia, Iran voluntarily participated in the study after completing an informed consent form in 2010. Venous blood samples were collected in three stages: prior to, immediately and 3 h after an incremental exercise (12 km/h at a 5% gradient for 20 min). Real-time PCR was used to assess superoxide dismutase1 (SOD-1) gene expression as was an autoanalyzer for hydrogen peroxide (H2O2) and LDH concentrations.
Results: LDH concentration significantly increased in both stages of the exercise (immediately and 3 h after the exercise), (respectively, P=0.009 and P=0.026), but H2O2 concentration significantly increased only in the recovery phase (P=0.002). SOD-1 mRNA did not significantly increase in any stage of the exercise (P=0.05). Moreover, there was only a significant correlation between SOD-1 mRNA and H2O2 increase (P=0.014).
Conclusion: Incremental exercise increased H2O2 and LDH levels in female athletes but only free radicals had a significant effect on SOD-1 gene expression.
Bakhtyar Tartibian , Rounak Parse, Behrouz Baghaiee ,
Volume 71, Issue 6 (September 2013)
Abstract
Background: The aim of this research was to determine the effect of olive oil on interleukin 6 (IL-6), Tumor necrosis factor a (TNF-a) and cortisol hormone in response to exhaustive exercise in active girls.
Methods: Twenty four healthy girls aged 21-27 years participated in this study. The subjects were randomly assigned to supplement (n=12) and control (n=12) groups. Supplemented group was fed with olive oil for one week. Blood samples were taken in a week before of exercise test, before exercise, immediately and 1 hour after the end of the exercise.
Results: There was a significant increase in the level of cortisol, IL-6 and TNF-α in the supplement and control groups in compared with a week before of exercise test and before exercise test (P≤0.05). There was no significant difference in cortisol levels between the two groups (P≥0.05), but there was a significant difference between the levels of TNF-α and IL-6 in immediately and one hour after the end of exercise (P≤0.05). These markers were lower in the supplement group.
Conclusion: Our results show olive oil prevent from increasing inflammatory markers in active girls during exhaustive exercise.
Mahdieh Shojaa, Mehrdad Aghaie , Mahsa Amoli , Patricia Khashayar , Naemeh Javid, Fatemeh Shakeri, Mostafa Qorbani , Ramin Mohebbi,
Volume 73, Issue 2 (May 2015)
Abstract
Background: Cytotoxic lymphocyte antigen-4 (CTLA-4) plays an important role in regulating T cell activation. CTLA-4 gene polymorphisms are related with genetic susceptibility to various autoimmune diseases, including systemic lupus erythematosus (SLE). We analyzed the role of CTLA-4 polymorphisms at positions -318CT in patients who suffer from SLE.
Methods: This study was performed on 180 SLE patients referred to 5th Azar University Hospital in Gorgan, Iran. Three hundred and four ethnically-and age-matched healthy controls with no history of autoimmune diseases entered the study between 5th May 2008 and 23rd October 2009. DNA was extracted from blood samples according to the standard procedure. Polymerase chain reaction- restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotype and allele frequencies of this polymorphism. PCR was carried out using the following primers: forward 5′-AAATGAATTGGACTGGATGGT-3′ and reverse 5′-TTACGAGAAAGGAAGCCGT G-3′. The frequency of alleles and genotypes were assessed using direct counting. Chi-square test and Fisher’s exact test were used to compare the association between the alleles and genotype frequencies and SLE. P<0.05 were considered statistically significant.
Results: The CC genotype was observed in 94.5% of the SLE patients and 82.4% of the controls the difference was statistically significant (P=0.0001, OR=3.51, CI95%=1.77-7.53). The CT genotype, on the other hand, was more frequently observed in the control group (17.1% vs. 5.5%, P=0.0001, OR=0.28). T allele was significantly more common in the controls compared to SLE patients (P=0.0001, OR=0.26, CI95%=0.13-0.53).
Conclusion: Our results suggest that the -318C/T polymorphism of CTLA-4 gene might play a significant role in the genetic susceptibility to SLE. Therefore, further studies on populations, especially from other Middle East countries, are needed to confirm our results.
