Showing 12 results for Akbari Asbagh
F. Akbari Asbagh, A Khademi,
Volume 56, Issue 1 (30 1998)
Abstract
Mullerian anomalies are one of the interesting but uncommon entities that gynecologists confront. The incidence is 1-6%, It is difficult to" anticipate the real incidence, because most of information is obtained from infertile or complicated patients with inadequate work-up. Recently endoscopic pocedures reveal more details about these anomalies. Today, classification of Buttram & Gibbons (modified by AFS [American Fertility Society]) is accepted. In this paper one patient with septate uterus, duplication of cervix and vaginal septum is introduced. According to information obtained, only one similar case is reported (by McBean et al). This entity is not conformed with AFS classification. Only in Toaff et al classification, there is a class similar to these patients. This entity is not explained by classic embryological theory of mullerian development
F Akbari Asbagh ,
Volume 56, Issue 4 (1 1998)
Abstract
Two hundred charts of infertile patients who admitted from April 1995 until March 1996 at Mirza Koucha Kkhan Hospital, retrospectively were reviewed. In this study, the results of hysterosalpingograms and laparascopy of all patients were evaluated. The goal of this study was: whether polypoid alterations and endometrial hypertrophy were a cornerstone sign for endometriosis. Among 32 patients who showed endometrial hypertrophy or polypoid hypertrophy only 3 has had endometriosis in laparascopy which were proved by histopathology, while 22 out of 168 with normal hysterosalpingograms revealed endometriosis. In conclusions: hypertrophic alternations and polypoid changes of endometrium could not be a good sign for endometriosis, and normal hysterosalpingograms do not rule out the endometriosis.
Akbari Asbagh F,
Volume 58, Issue 3 (7 2000)
Abstract
Clomiphene critrate is an effective and safe treatment for anovulation, but in some cases resistance occurs. To evaluate the efficacy of Dexamethasone in resistant anovulatory normal Dehydroepiandrosterone patients, we prospectively studied 57 infertile resistant anovulatory women. Each woman received 100 mg daily clomiphene critrate from cycle days 3-7 and 0.5 mg Dexamethasone from cycle days 3-12 at night. Serial ultrasonography was performed and hCG (5000-10000 IU) was administered when the follicles reached 17-18 mm in diameter. Ovulation in 80.7% and clinical pregnancy in 29.3% patients were achieved in 92 treatment cycles. The average dominant follicles>16.1 mm was 2.42. The endometrium thickness in 61.4% was greater than 8 mm. Nor adverse reaction of clomiphene critrate neither hyperstimulation were encountered. Ovulation and pregnancy rates were similar in both primary and secondary infertile groups. According to low cost, less side effects and effectiveness, we recommend combination of clomiphene critrate and Dexamethasone in patients with normal DHEAS resistant anovulation.
Akbari Asbagh F,
Volume 59, Issue 1 (7 2001)
Abstract
The objective of this study was to examine the correlation between both midfollicular FSH/LH ratio and number(s) of follicles with ovarian hyperstimulation syndrome (OHSS) in patients with polycystic ovarian syndrome (PCOS). This was carried out in IVF unit at Mirza Kouchak Khan Hospital. To induce ovulation, PCOS patients were stimulated with gonadotropines. Fifty four PCOS patients with normal basal level of FSH, LH were studied prospectively. 22 patients did not receive HCG and stimulation cycle was canceled due to OHSS. 32 patients received HCG and stimulation cycle was completed. In all patients mid-follicular (day 8 of stimulation protocol) serum FSH/LH ratio was measured. On the same day number of ovarian follicles were also counted using vaginal sonography. In canceled cycles, LH on day 8 was shown to be low along with increased number of follicles. The risk of cycle cancelation raised twice with one increment of FSH/LH ratio. Also, with increase of one follicle the risk of cycle cancellation increased 1.3 times. To induce ovulation by gonadotropine stimulation in PCOS patients, the dose should be carefully monitored. Measuring FSH/LH ratio and number of follicles on day 8 of stimulation protocol are reliable guides in order to predict those patients prone to develop OHSS.
Assadi F , Akbari Asbagh P, Hajizadeh N,
Volume 64, Issue 10 (2 2006)
Abstract
Background: Microalbuminuria (MA) is associated with increased cardiovascular risk in hypertensive patients, but not many studies have specifically examined the effects of MA-lowering on regression of left ventricular hypertrophy (LVH) among pediatric patients with hypertension.
Methods: Fifty-five patients with essential hypertension, 11 to 19 years old were prospectively studied. All patients received concomitant therapy of hydrochlorothiazide and angiotensin-converting-enzyme inhibitor. Five patients also required angiotensin-receptor blocker to achieve the blood pressure goal. Baseline and 12-month follow-up measures of left ventricular mass index (LVMI) determined by echocardiography and urine microalbumin/creatinine ratio (MA/Cr) were collected. MA was defined as MA/Cr>30. LVH was defined as LVMI>38.6 g/m2. The primary end points were 25% or more reductions in MA and the LVMI.
Results: Weight (r=0.83), body surface area (r=0.85), body mass index (BMI) (r=0.86), systolic blood pressure (SBP) (r=0.57), diastolic blood pressure (DBP) (r=0.49), mean arterial pressure (r=0.53) and MA (r=0.87) were all univariate correlates of LVMI. In a multiple regression analysis, MA, BMI and SBP were significant correlates of LVMI. MA alone explained 76% of the variance of LVMI, whereas BMI and SBP explained only 1.6% and 0.4% of the variance, respectively. MA was the most significant correlate of follow-up LVMI after BMI and SBP were included in the overall multiple regression models.
Conclusion: MA is a strong predictor of LVH in hypertensive children and adolescents. MA-lowering halts the progression of LVH or induces its regression.
Nayeri F, Kheradpisheh N, Shariat M, Akbari Asbagh P,
Volume 67, Issue 4 (6 2009)
Abstract
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Background: Low-birth-weight (LBW) children are at
higher risk for failure to thrive. The aim of the study was to establish the
trend of physical growth in Until now their growth
was evaluated with normal birth weight baby's chart.
Methods: In this cohort study we investigated demographic characteristics and growth
trend during the first of life 406 newborn divided into
three groups: LBW (Low
Birth Weight)
n=103, VlBW
(Very Low
Birth Weight)
n=20 and NBW
(Normal Birth
Weight) n=303.
Body weight, length and head circumference were measured at the time of birth
and several follow ups until 12 months of
chronological age.
Results: NBW growth trend adopts the standard chart. Significant
differences in terms of physical growth (weight- height- head circumference)
were seen between the two groups of preterm (LBW & VLBW)
and NBW children. Although
it was demonstrated that growth velocity of preterm &
NBW children were the same. Significant differences for weight was seen
between VLBW and LBW
group only until 6 months after birth. This
difference was seen for height and Head circumference until the end of the
first year of life.
Conclusions: VLBW
and LBW babies need special growth charts. But
the adjustment method of anthropometric traits to gestational age may be useful
to evaluate LBW baby's growth.
Firoozeh Akbari Asbagh, Mahak Papan, Zahra Khazaeipour,
Volume 67, Issue 12 (6 2010)
Abstract
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Background: Insulin resistance is common in women with Polycystic
Ovary Syndrome
(PCOS) and can cause poor outcome of infertility
treatment. The aim of our study
was to assess the effect of treatment with metformin on outcome of Intra
Cytoplasmic Sperm
Injection (ICSI)
in infertile PCOS women.
Methods: A randomized clinical trial study was carried
out in infertile women with PCOS, before ICSI,
referred to infertility clinic of Mirza
Koochackhan Hospital
of Tehran University
of Medical Science
Tehran, Iran,
between 2006 and 2008.
The patients were randomized in two groups of
metformin 500 mg Po,
three times daily, six weeks before the ICSI
cycle and placebo patients in each group were divided into BMI
<28 kg/m2 and BMI
&ge28 kg/m2.
Results: Of 52
study women 26(50%) were in metformin
group. mean age were 29.8±4.9 year in
metformin group versus 29.4±5.9 year and
placebo groups. Treatment with
metformin, in subgroup of BMI <28 kg/m2,
significantly increased number of mature follicle (p=0.01),
embryo (p=0.04),
oocytes (p=0.007)
and mature oocytes (p=0.03)
but in subgroup of BMI&ge28 kg/m2,
there was no significant difference in the metformin and placebo groups (p>0.05).
Metformin treatment caused more chemical and
clinical pregnancy rates, and less abortion rate in overweight and normal patients,
but the differences were not significant (p>0.05).
Logestic regression analysis showed, adjusting
number of mature follicle, number of embryos, quality of embryos, oocytes and BMI
and treatment showed no significant effect on clinical pregnancy
rates (p>0.05).
Conclusions: Among normal weight PCOS
women, effect of treatment with metformin is better than overweight PCOS
women. However further
studies are needed.
Naseraldin Akbari Asbagh , Parvin Akbari Asbagh , Zarrintaj Keihanidoust , Aliashraf Eghbali ,
Volume 71, Issue 5 (August 2013)
Abstract
Background: Long QT syndromes (LQT) are genetic abnormalities of ventricular repo-larization, with an estimated incidence of about one per 10000 births. It is characterized by prolongation of the QT interval in electrocardiogram (EKG) and associated with a high risk for syncope and sudden death in patients. Type of this syndrome is association with congenital deafness. Our objective was to evaluate QT interval in children with congenital deafness.
Methods: For 219 patients referred to Imam Khomeini Hospital audiometric clinic in 2011, questionnaire were completed. A total of 23 congenitally deaf children were incl-uded. All patients’ examinations were done by a pediatric cardiologist. Electrocardio-gram is conducted in all children (23 patients) with sever and deep congenital deafness. Then the QT interval was measured based on Bazett’s formula. Echocardiography was also performed in these children to assess left ventricular function and the presence of mitral valve prolapse.
Results: The overall patients were two hundred and nineteen children. A total of twenty three congenitally deaf children were included and electrocardiogram was obtained. Three children had obviously prolonged QTc (0.48±0.02) second. The median age of them was 6.1±5 year, the median weight was 18±11.3 kilogram and the median of QT interval was 0.48±0.02 second.
Conclusion: The QT interval obtained 0.48±0.02 second. In the present study we found prolonged QT in congenital deafness, thus we recommend to evaluate the electrocardio-gram of children with congenital deafness.
Parvin Akbari Asbagh , Mohammad Reza Zarkesh , Firoozeh Nili , Fatemeh Sadat Nayeri , Azam Tofighi Naeem ,
Volume 73, Issue 2 (May 2015)
Abstract
Background: The incidence of Patent Ductus Arteriosus (PDA) in premature infants whose birth weight is less than 1500 grams is approximately 30-60%, most of them need medical or surgical interventions. The purpose of this study is to determine the efficacy of prophylactic treatment with oral paracetamol (Acetaminophen- Hakim® Oral Drops 100 mg/ml, Hakim Pharmaceutical Co., Tehran, Iran) for PDA in preterm infants.
Methods: A randomized clinical trial conducted from March 2012 to March 2013. Thirty-two preterm newborns whose gestational age was under 32 weeks and birth weight was 1500 grams or less, admitted in neonatal intensive care unit (NICU) of Vali-Asr Hospital, Tehran were studied prospectively. They were randomly assigned in two groups. The prophylaxis group received oral paracetamol for a period of two days starting during first 24 hours of life. No placebo was given to the control group. Echocardiography was performed 24-36 hours after the last given dose in prophylaxis group and on the 4th and 5th day in control group. A p-value less than 0.05 are considered significant.
Results: There were 16 newborns in each group (20 boys and 12 girls). In 12 newborns of prophylaxis group the ductus arteriosus was closed although in control group in 8 newborns the duct was closed. No significant difference was observed in sex, gestational age, birth weight, mode of delivery, multifetal gestation and birth order between two groups. The rate of ductal closure was 75% and 50% in prophylaxis group and control group respectively (P=0.27).
Conclusion: Our study demonstrated that prophylactic paracetamol is ineffective in PDA closure, although the rate of ductal closure between two groups seems remarkable. Paracetamol as a new strategy for PDA closure because of cost effectiveness and harmlessness may be used in future. However, we presume larger sample size studies are needed to show the efficacy of paracetamol, side effects, and complications in PDA prophylaxis treatment.
Gholamreza Pourmand , Mohsen Ayati , Ali Razi , Aliakbar Karami , Rashid Ramazani , Ayat Ahmadi , Parvin Akbari Asbagh, Rahil Mashhadi , Shadi Pourmand ,
Volume 73, Issue 5 (August 2015)
Abstract
Background: Prostate-Specific Antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is the best marker for early diagnosis of prostate cancer. Since age and race are affecting PSA levels, determining age-specific reference ranges of PSA in every community is necessary for increasing the efficiency rate of PSA. The aim of the present study was to evaluate the normal distribution of total prostate-specific antigen (TPSA) and free prostate-specific antigen (FPSA) and determine age-specific reference ranges of PSA in Iranian men.
Methods: In this cross-sectional study, 1200 normal men with the age range of 50 to 79 referred to Shahid Rajaie Hospital, Qazvin Province in Iran, from 2011 to 2013. After excluding patients with prostate cancer and urinary tract infection, 1020 men were included in this study. Then, their blood samples were collected and after the extraction of serum from blood, serum levels of FPSA and TPSA were measured using commercial kits the reference range of PSA was specified for each age group and compared with reference ranges of other populations.
Results: The mean age of the patients was 61.03±7.5 years and the mean values of FPSA and TPSA were 0.47±0.6 ng/ml and 1.56±2.05 ng/ml, respectively. PSA serum levels (95th percentile range) in 50 to 59, 60 to 69 and 70 to 79-year age groups were 0-3.6 ng/ml, 0-5.7 ng/ml and 0-6.8 ng/ml, respectively. TPSA (r= 0.2, P< 0.001) and FPSA (r= 0.22, P< 0.001) were significantly associated with age. In addition, a significant relationship was found between TPSA serum levels and alcohol consumption (P= 0.017), smoking (P< 0.001) and family history of prostate cancer (P= 0.014).
Conclusion: Findings of the present study showed that PSA levels are correlated with age. It was also revealed that the PSA age-specific reference range obtained in this study is different from other races and is specific to Iranian men. Therefore, age-specific reference ranges of PSA obtained in the present study can increase PSA test sensitivity and specificity by reducing unnecessary diagnostic procedures and early detection of prostate cancer in Iranian men.
Atoosa Bagheri Behzad, Barzin Bagheri Behzad , Hassan Niroomand , Mahbod Ebrahimi , Gholamreza Poormand , Firoozeh Akbari Asbagh,
Volume 73, Issue 9 (December 2015)
Abstract
Background: Infertility is defined as failure to achieve pregnancy after one year of unprotected sexual intercourse. Infertility can be related to male or female factors. Varicocele is the most common cause of infertility in men that is correctable with surgery. The purpose of this study was to determine the effects of recombinant follicle-stimulating hormone (rFSH) on semen parameters in infertile men.
Methods: This randomized clinical trial was done on 96 infertile men admitted to the Women's General Hospital Mohebe-Yas from September 2014 to September 2015. Inclusion criteria were to include varicocelectomy for unilateral idiopathic varicoceles and consent to participate in the study. Allergy to the drug combination and patient dissatisfaction were exclusion criteria. Patients participating in the study were divided into two groups randomly, one group received recombinant FSH three times a week and the other group received a placebo (normal saline) in the same way. After three months, the improvement of semen parameters, including motility, morphology and sperm count as well as the complications were determined in both groups. The data were analyzed with statistical software SPSS version 13 (Chicago, IL, USA).
Results: A total of 96 patients were enrolled in two groups of 48 men and women both groups were matched in terms of underlying factors. The rate of improvement in the morphology and motility of sperm in the treated group was significantly more than the placebo group (P= 0.0001) but the changes in sperm count were not significantly different between the groups (P= 0.495).
Conclusion: In summary, based on the results obtained in this study, it can be concluded that recombinant FSH is effective on improving semen parameters in infertile men after varicocelectomy compared with a placebo group and its major impact is on the morphology and motility of sperm.
Parvin Akbari Asbagh, Ali Zamani , Seyed Reza Raees Karami , Mohammad Mahdi Zahrabi , Yasamin Mohammadzadeh ,
Volume 74, Issue 5 (August 2016)
Abstract
Background: Acute osteomyelitis is one of pediatric emergency which can cause unpleasant complications among them. This is especially accurate if the diagnosis had been delayed or the treatment was inappropriate. There is some misunderstanding in the detection of patients’ hospital files and it’s difficult to detect the diagnostic and treatment malpractice. We performed an investigation of the clinical and paraclinical data in children with acute osteomyelitis.
Methods: We performed a retrospective cross-sectional study in pediatric department of Imam Khomeini University Hospital in Tehran, Iran, from April 1997 to March 2010. The hospital records of all neonates and children from 15 days old to 15 years old were investigated. Patients with any defect in records were excluded from the study. A total of 54 children were included in this study. A questionnaire including clinical features, paraclinical findings and treatment response was completed for all subjects by design's executer. Data were analyzed using the software package SPSS version 16 (IBM, Armonk, NY, USA).
Results: In general, 35 children were male and 19 children were female. The average of age was 5.89 years. Children were divided into 4 groups based on age (less than 2, 2-7, 7-12 and 12-15 years) that majority of them were less than 2 years old (38.9%). The most common symptom and sign were pain (46.3%) and swelling (88.8%) respectively in this study. The most primary presenting symptoms were pain (46.3%) and swelling (24.1%). The comparison of frequency ranges of fever between children younger than 2 years and children 2-15 years old demonstrated a significant different (14.3% vs 84.8%, respectively) (P= 0.001). Staphylococcus aureus was the most commonly isolated organism (73.5%). Thirty-two patients (59.2%) needed surgical procedures in addition to antibiotic therapy that had successful outcome in all cases. The average of treatment duration with intravenous antibiotic was 28.14±12.84 days.
Conclusion: More than half of the children with acute osteomyelitis didn't response to antibiotic therapy and they needed different types of surgeries.
