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Showing 3 results for Amani F
Detection of Outliers methods in medical studies
Babaee Gh, Amani F, Biglarian A, Keshavarz M,
Volume 65, Issue 7 (4 2007)
Abstract
Background: An outlier is an observation that lies an abnormal distance from other values in a random sample from a population. Outliers sometimes deal with to abnormality in obtained results from collected data and information. known outlier data by researchers, physicians and other persons that work in medical fields and sciences is important and they must control data before getting result about outlier data, effect of them in information bias and how to remove & control to obtain minimum bias and exact data .in this paper we had trying by known technique and tests to control them and minimized the errors related to them.
Methods: This paper has been done on 30 student's height in Tarbiat Modares University that measured by meter in smoothing area. We applied some methods such as Z-test, Grub test and graphical methods to determine outliers. In this paper the advantage and disadvantage of methods were evaluated and finally compares with each other.
Results: The above tests showed that the data values 153, 110 among collected data were outliers. All of the methods showed that the above data were outliers. Calculation quartiles and intermediate quartiles showed that the observations under 125 and upper 141 were mind outliers and if the observation under 119 and upper 147 is the sever outliers. According to upper situations the amounts of 110 and 153 is the sever outliers and resulted from all methods.
Conclusion: The results showed that all methods were useful in determine outlier data and between them Quartiles were important to known severe and mild outliers. Also Grub test with p-Value is very useful to report outliers.
Comparison of serum vitamin D levels in children one to six years with urinary tract infections and healthy children
Fatemeh Khanamani Falahati Pour, Saeedeh Parvaresh, Maedeh Jafari,
Volume 79, Issue 7 (October 2021)
Abstract
Background: Urinary tract infection is one of the most common infectious diseases in children, the most severe form of which is acute pyelonephritis. Vitamin D plays a very important role in regulating the immune system, this study was conducted to compare vitamin D levels in children with urinary tract infections and healthy children in Kerman, Iran in 2020.
Methods: This cross-sectional study was performed on 63 children with pyelonephritis hospitalized in Afzalipour Hospital and 68 healthy children who were referred to Samen Al-Hojaj Clinic in Kerman, Iran from January 2020 to January 2021. Inclusion criteria for patients include the following: a) the presence of clinical signs and symptoms of infection such as fever b) pyuria, neurogenic bladder, urinary stones, chronic renal failure and previous diagnosis of urinary reflux. The case group was evaluated by taking a complete history, completing a questionnaire and clinical examination, and laboratory tests. The two groups were compared in terms of variables of sex, age and vitamin D levels.
Results: The mean age of the case group was 34 months and that of the control group was 38 months. The mean serum levels of vitamin D in the case and control groups were 34.66 and 42.9, respectively). P=0.016( Each group was divided into three groups according to the amount of vitamin D, including groups 1, 2 and 3, respectively, with vitamin D levels below 25 nanomoles per liter of deficiency, 25 to 50 inadequate and above 50 as the appropriate amount of vitamin D was considered. There was no significant difference between girls and boys in terms of vitamin D deficiency compared to the three groups of vitamin D levels.
Conclusion: Inadequate vitamin D levels are associated with the prevalence of urinary tract infections, and vitamin D supplementation can be a low-risk option for preventing urinary tract infections.

Effect of cell therapy compared to renin-angiotensin-aldosterone system blocking agent in chronic kidney disease in cat-animal model
Nahid Askari, Ali Ali Shafieipour , Soudeh Khanamani Falahati-Pour,
Volume 81, Issue 5 (August 2023)
Abstract
Background: Mesenchymal stem cell (MSC) transplantation is a promising therapy for kidney repair. This study compared the regenerative effects of feline MSCs (fMSCs) and telmisartan, a renin-angiotensin blocker (RAB), in a feline model of chronic kidney disease (CKD).
Methods: The fMSCs were obtained from 35 Persian cats with CKD and characterized by CD44, CD90, and CD105 markers by using real-time RT-qPCR. The cats were randomly allocated to four groups, fMSCs injection (first group), telmisartan administration (second group), no treatment (third group), and healthy controls (fourth group). The study was conducted in Kerman province from December 2018 to December 2019. The factors that may affect the risk of CKD, such as age, weight, and history of kidney diseases, were considered as independent variables. The presence or absence of CKD was the dependent variable. The cats were followed up for 120 days and evaluated by physical examination, glomerular filtration rate (GFR), blood urea nitrogen (BUN), serum creatinine (SCr), serum urea, alanine transaminase (ALT), urine specific gravity (SG), and kidney histopathology. Statistical analysis was performed using SPSS software (version 20) with two-way ANOVA and Tukey test. P<0.05 was considered statistically significant.
Results: The fMSCs group showed significant improvement in GFR, BUN, SCr, serum urea, SG, and kidney histology compared to the other groups. The fMSCs group also showed increased expression of CD44, CD90, and CD105 genes in the kidney tissue, indicating enhanced stem cell activity. The telmisartan group showed modest improvement in blood pressure and proteinuria, but no significant effect on other parameters. fMSCs transplantation can restore the kidney function and structure in cats with CKD by modulating the apoptosis and proliferation of renal cells. The telmisartan  patients benefited from the anti-hypertensive and anti-proteinuric effects of the drug, but not from its anti-fibrotic or anti-inflammatory effects.
Conclusion: fMSCs transplantation was more effective than telmisartan in improving kidney function and reducing kidney damage in cats with CKD. fMSCs may be a potential therapeutic option for CKD patients.

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