Farnaz Amouzegar- Hashemi, Alireza Alaleh, Ali Kazemian, Peiman Haddad,
Volume 67, Issue 12 (6 2010)
Abstract
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Background: Breast conservative therapy is associated with
similar outcomes in comparison with mastectomy. The
aim of this study is assessment of local recurrence rate and related risk
factors in patients who have been treated with radiotherapy after conservative
surgery for breast cancer.
Methods: This is a cohort study which data of all breast
cancer patients who have visited in follow up clinic in radiation oncology
department of cancer institute of Imam
Khomeini Hospital
complex in Tehran, Iran,
during years 2007-2009 were collected. All
of the patients were investigated for local recurrence and the possible risk
factors.
Results: Two hundred and seventy seven patients have entered
the study and all have followed for at least one year since data entry. Median
follow-up time from the start of radiotherapy were 35
months (12-148 mo).
We had seven cases (2.5%)
with local recurrences (2.5%)
which most of them occurred in first year after treatment. Because
of low rate of recurrence none of the variables such as margin and nodal status
has significant correlation with local recurrence which this should be due to
small number of patient and short time of follow up.
Conclusions: At
median follow up of 35 months from the beginning
of radiation therapy, local recurrence rate was 2.5% which
is similar to the literature. We recommend to follow a
larger group of patients for longer times to estimate recurrence risk after breast
conservative therapy.