Parviz Deyhimi , Mahmoud Reza Arefian , Parvin Mahzooni ,
Volume 72, Issue 10 (January 2015)
Abstract
Background: Fibromatosis includes a variety of fibroblastic proliferation whose biological trend and histopathological patterns are at intermediate level between benign fibroblastic lesions and fibrosarcoma. Accordingly, because of overlapping of histopathologic features of fibrosarcoma, particularly low-grade type, with fibromatosis, the present study was conducted to find more precise criteria for histopathological and immunohistochemical (IHC) differentiation of these lesions.
Methods: In this cross-sectional descriptive analytical study, a total of 40 specimens from pathology department archives in hospitals of Isfahan and Tehran universities from 2003 to 2013, including 20 fibrosarcoma and 20 fibromatosis biopsies, were selected. First, histopathologic characteristics were identified using H&E slides and an optical microscope H&E slides and then they were stained through immunohistochemical staining technique using the EnVision for markers Ki-67 and β-catenin. Afterward the samples were examined by optical microscope and positively stained cells were counted.
Results: There was no significant difference between fibromatosis and fibrosarcoma in terms of a mean age (P=0.063), distribution of gender frequency (P=0.197), necrotic rate (P=0.602), clarity of nucleolus (P=0.799) and SID mean of β-catenin marker (0.369). However, it was seen a meaningful difference between fibromatosis and fibrosarcoma in terms of frequency distribution (P=0.017), rate of mitotic figures (P<0.001), rate of herring-bone pattern (P=0.043), rate of cellularity (P<0.001), rate of nucleus overlapping (P<0.001), mean of Ki-67 (P=0.046), mean of Ki-67-limit (P=0.001) and atypia rate (P<0.001).
Conclusion: There was a meaningful difference between fibrosarcoma and fibromatosis in terms of mitotic figures, expression of Ki-67 mitotic marker, herring bone pattern, cellularity and atypia. Therefore these features can be used to differentiate the relevant pathological lesions. However, no meaningful difference between two tumors in terms of expression and intensity of β-catenin, clarity of nucleoli and necrosis. This indicates that they are not reliable criteria of differentiation between fibrosarcoma and fibromatosis.
Hamidreza Azizi Faresani , Shayesteh Khorasanizadeh, Noormohammad Arefian , Houman Teymourian , Gholamreza Mohseni , Faranak Behnaz , Hamideh Ariannia ,
Volume 79, Issue 5 (August 2021)
Abstract
Background: This study aimed to evaluate the effect of intravenous Ibuprofen Apotel analgesia in comparison with intravenous Morphine alone regimen in patients undergoing lubmar disc surgery.
Methods: This study was a double-blind clinical trial that was performed on patients with moderate to severe lumbar disc pain (VAS score or Visual analog scale more than 4) in August 2019 at Shohada Tajrish hospital. Patients in the Ibuprofen-Apotel group (group A) recieved intravenous Ibuprofen (800 mg) in 100 cc Normal saline in the first 30 minutes of Recovery, then 400 mg in 100 cc Normal saline every 6 hours (48 hours after surgery), plus 30 mg Apotel for each kilogram in100 cc Normal saline in 15 minutes every 8 hours. In group B, Morphine has injected with 70 µg/kg bolus and then 20µg/kg/h infused with a PCA pump with a Maximum Rate of 1mg/hr. Then 60 minutes after surgery, patients' pain was measured using an analog scale.
The primary outcome was defined as a reduction in pain intensity of 3 or more VAS units (which was considered as therapeutic success) and the incidence of side effects was considered as secondary outcomes.
Results: Based on the results of this study, the mean age of the subjects was 33.28±12.48 years. Also, the mean age in the group of Ibuprofen-Apotel and Morphine alone were 35.4±13.6 and 31.16±11.75 years. So, there is not a significant difference between the groups. 77.14% of the subjects (54 people) were male and 22.86% (16 people) were women. In comparing the frequency distribution of individuals in terms of gender and the method of creating analgesia, no significant difference was observed between the groups studied.
According to the results, after the intervention, the highest pain intensity in both groups was significantly decreased. However, no significant difference was observed between the two groups.
Conclusion: The study indicated that Ibuprofen can be effective in controlling postoperative pain.
