Showing 11 results for Azadi
Moghaddami Tabrizi N, Eazadi Mood N, Tahmasbi M,
Volume 59, Issue 4 (9 2001)
Abstract
The pre-eclampsia/eclampsia is one of the commonest conditions peculiar to pregnancy, to describe the occurrence of hypertension, proteinuria and edema in pregnancy. It is about seven times more frequent in first gestation and uncommon before 20 week's gestation. Serum BhCG levels were prospectively determined in 260 midtrimester singleton pregnancies where admitted from October 1999 until September 2000 at Mirza Kouchak Khan hospital, prenatal clinic. Obstetric chart review was undertaken after delivery to identify cases in which pre eclampsia developed. The median maternal age was 26.0 years, and the median gestational age at the time of blood collection was 19.0 weeks. Of these, 17 cases (6.5 percent) had pre eclampsia. The median level of the BhCG was 35060.5 mlu/ml in those with pre eclampsia, whereas that in those without pre eclampsia was 33755.1 mlu/ml. The difference was not significant (P=0.28). Although elevated midtrimester serum BhCG levels in clinically normal patients was reported in severaly pre eclampsia women, this is not a good test for early detection of mild pre eclampsia.
Iarandi F, Eftekhar Z, Eazadi N, Beik M,
Volume 59, Issue 4 (9 2001)
Abstract
The use of Frozen-section during surgical procedures, gives the surgeon valuable information and guides him to perform the appropriate surgical procedure. In order to determine the accuracy of Frozen-section in gynecologic surgery, we compared the results of 172 gynecologic Frozen-section diagnosis with their final diagnosis in Mirza Kockak Khan Hospital, from 1378 to 1379. A total of 106 ovarian, 43 uterine, 10 lymph node and 13 other tissue samples were obtained. The Frozen-section diagnosis was compatible with the final diagnosis in 93.6 percent of cases. The sensitivity for non benign lesions was 82.5 percent and the specificity was 96.8 percent. The positive and negative predictive values were 84 percents and 98 percent respectively. 2.3 percent of cases were falsely positive, 1.7 percent falsely negative and 1.2 percent over estimated the degree of malignancy. There was no underestimation and 1.2 percent were uncertain. Frozen-section was found to identify correctly 8 of 8 metastatic ovarian tumors and 1 of 2 germ cell tumors. The accuracy of Frozen-section was 25 percent in ovarian borderline tumors, 60 percent in ovarian mucinous and 80 percent in serous tumors. With the exception of borderline and mucinous ovarian tumors, Frozen-section diagnosis is sufficiently accurate for clinical use. Performing multiple sections is recommended in the Frozen-section diagnosis of mucinous ovarian tumors.
Tahmasby Mt, Moghtader Azadi Gh,
Volume 61, Issue 2 (14 2003)
Abstract
Arthrofibrosis continue to be a difficult complication of operative procedures of trauma about the knee. We present our experience in 8 cases of arthroscopic Arthrolysis between 1997 and 2001. in 3 Cases the etiology was prior Knee ligament surgery and 5 cases had sustained fractures about the knee. Technique begins with the liberation of the adhesions of suprapatellar Pouch, continues down both gutters , and ends with a cleaning of the notch where necessary. The result obtained are very satisfactory, with an average increase in the arc of mobility of 61 degrees.
Moghaddamy Tabrizi N, Mirzaei M, Eazadi Mood N,
Volume 63, Issue 4 (13 2005)
Abstract
Background: In 2-4% of couples in fertile ages, recurrent pregnancy loss (RPL) occurs which consisted one out of 300 pregnancies. The aim of this study was to comparison insulin resistance (IR) in patients with RPL to normal individuals.
Materials and Methods: In a case-controlled, prospective study, 49 non-pregnant, non-diabetic women with early RPL as the case group and 49 non-pregnant, non-diabetic women without RPL who had at least one live infant as the control group, and were matched by age, weight, and height, were enrolled. In both groups fasting insulin and glucose levels were measured and insulin resistance, which was defined as a fasting insulin (FI) level ≥20 microU/mL or a fasting glucose to insulin ratio (FGI ratio) of <4.5, was calculated.
Results: The RPL and control groups were similar with respect to age, BMI, fasting glucose levels and glucose to insulin ratios. FI was significantly higher in RPL group than control group (15.20±5.82 vs. 12.23±5.64 microU/mL). Also the frequency of patients with high FI (FI≥20µU/ml) in RPL group was significantly higher than in control group (22.45% vs. 6.12%, Odds Ratio=4.44, Confidence Interval 95%=1.15-17.07). Among the RPL group, 24.49% demonstrated insulin resistance, whereas only 8.16% of the matched controls were insulin resistant (Odds Ratio=3.65, Confidence Interval 95%=1.08-12.26). The RPL and control groups had similar in frequency of low FGI ratio. Also there was no significant difference between mean of FGI ratio in patients with fewer than 12 weeks miscarriage compared to over 12 weeks in RPL group.
Conclusion: Women with RPL have a significantly increased prevalence of insulin resistance when compared with matched fertile controls. It's recommended that in all women with RPL the glucose and insulin measurement should be carried.
Alizadeh R, Ziaee V, Movafegh A, Yunesian M, Azadi Mr, Mehraein A,
Volume 64, Issue 10 (2 2006)
Abstract
Background: Both hypoxia and hypocapnia can cause broncho-constriction in humans, and this could have a bearing on performance at high altitude. The objective of this study was to examine how pulmonary ventilatory function during high-altitude trekking.
Methods: This study was a before and after study on spirometric parameters at Base line (1150 m above sea level), and after ascending at 4150 m above sea level. This study was performed in summer 2004 at Cialan Mountain in Iran. Fifty six healthy male University student volunteers were enrolled in the study. Respiratory function was assessed in participants before ascending at baseline (1150 meter) and after ascending at 4150 meter in Cialan Mount with a Spirolab II. Spirometric parameters changes were compared using paired t-test statistical analysis computations were performed by spss 11.5 and p≤0.05 was considered significant.
Results: The mean age and body mass lindex of our subjects were 22.9±5.3 years and 21.5±2.5, respectively. Forced vital capacity (FVC) was significantly decreased with increasing altitude from baseline level (P<0.01). Forced expiratory volume in 1 second to forced vital capacity ratio (FEV1/FVC) and maximal midexpiratory flow rate (FEF 25-75%) were significantly increased with increasing altitude (P=0.001). There was no significant change in forced expiratory volume in 1 second and peak flow (P>0.05). FVC fell by the average of 7.1% at 4150m (2.4% per 1000m increased altitude) in comparison to 1150m.
Conclusion: The changes in some pulmonary ventilatory parameters were proportional to the magnitude of change in altitude during a high-altitude trek.
Fazeli Mr, Abbaspour M, Ghahremani Mh, Alimian M, Ilka H, Jamalifar H, Azadi S, Azizi E,
Volume 64, Issue 12 (6 2006)
Abstract
Background: Aluminum salts are common adjuvants in human and animal vaccine preparations. The two adjuvants aluminum phosphate and aluminum hydroxide show acceptable immunoadjuvant properties with many antigens. These two salts have different physicochemical characteristics that make each one suitable for certain antigens. The surface antigen of Hepatitis B (HBsAg) has several antigenic epitopes that bind to aluminum adjuvants by a ligand exchange mechanism. Although HBV vaccines using an aluminum hydroxide adjuvant are available, higher antigenicity is needed for the subgroup of people who do not respond sufficiently to the currently available vaccines.
Methods: A solution of recombinant HBsAg for making different formulations of vaccines with aluminum phosphate (Adju-Phos®) and aluminum hydroxide (Alhydrogel®) adjuvants was obtained from Darupakhsh Pharmaceutical Company. The total protein content, antigenicity, and purity of HBsAg solution were determined using BCA, ELISA, and SDS-PAGE methods, respectively. The different formulations were prepared in the lab and administered i.p. to two test groups of Balb/C mice and a third test group received the Engerix vaccine, which is currently available on the market and uses an aluminum hydroxide adjuvant. The control group of animals received the solution without antigen. After 28 days, heart blood samples were collected and serum was separated to determine the antibody titer against HBsAg using an ELISA kit.
Results: This study shows that the vaccine formulated with aluminum phosphate exerted more immunogenicity than both the aluminum hydroxide laboratory formulation and the Engerix vaccines.
Conclusion: Although the results of our study indicate higher immunogenic properties of the vaccine formulated with the aluminum phosphate adjuvant, complementary experiments are needed to further evaluate the biological properties with respect to effectiveness, adverse effects, product stability and finally possibility for manufacturing and distribution of this new formulation as a Hepatitis B vaccine.
Azadibakhsh N, Shaker Hosseini R, Atabak Sh, Nateghiyan N, Golestan B, Houshiar Rad A,
Volume 65, Issue 8 (3 2007)
Abstract
Background: Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. The frequency of hyperhomocysteinemia is higher in hemodialysis (HD) patients than the general population. The objective of this study is to assess the efficacy of high-dose folic acid supplementation with and without vitamin B12 on lowering plasma total homocysteine (tHcy) concentrations in HD patients.
Methods: Thirty-six HD patients at Imam Hossein Hospital, Tehran, Iran, who had been given folic acid supplements (5 mg/d) for at least 3 months before, were enrolled in this clinical trial. Subjects were also checked for other inclusion and exclusion criteria. The subjects were divided randomly into four groups and underwent two months of supplementation as follows: 5 mg/d oral folic acid + placebo in group one, 5 mg/d oral folic acid + vitamin B12 (1 mg/d orally) in group two, 15 mg/d oral folic acid + placebo in group three and 15 mg/d oral folic acid + vitamin B12 (1 mg/d orally) in group four. Concentrations of plasma tHcy and serum folic acid and vitamin B12 were measured at baseline and after the supplementation period. Dietary intake of patients was also determined during the supplementation period.
Results: Of the folic acid supplemented patients, 27.8% had normal levels of tHcy at baseline and 72.2% had hyperhomocysteinemia. After the supplementation period, plasma tHcy increased by 1.35% in group one and decreased by 6.99%, 14.54% and 30.09% in groups two, three and four respectively. Changes in plasma tHcy and serum vitamin B12 were only significant in group four however, no significant changes were seen for serum folic acid. The percentage of subjects reaching normal levels of plasma tHcy was 5.6 fold higher in group four than in the reference group.
Conclusions: Supplementation with 15 mg/d folic acid together with 1 mg/d oral vitamin B12 is more effective in reducing tHcy levels in HD patients.
Nammam Ali Azadi , Shahram Sadeghi , Mohammad Hossien Saghi ,
Volume 73, Issue 5 (August 2015)
Abstract
Background: One of the critical unit in each hospital is intensive care unit (ICU). The United States’ Environmental Protection Agency (EPA) recommends to control the noise level of this unit in order to not exceed 45 decibels (dBA) during the day and 35 dBA at night. In this study, our goal was to evaluate the noise level at adult and neonatal ICUs at some Sanandaj’s hospitals, Iran.
Methods: This cross-sectional study was conducted from May 4th to June 4th 2012 in adult and neonatal intensive care units at three major hospitals in Sanandaj (Besat, Tohid and Tamin-Ejtemaei). In order to assess the noise level properly, measurements obtained during the days and nights. At a given day, a unit was selected randomly and measurement of sound levels obtained successively within two-hour periods. The noise levels were measured in decibels using a sound level meter (SLM). This process took four weeks to be completed (one week per unit). In the end of study, the total of 336 records of noise levels were obtained. Descriptive analysis as well as fitting a mixed effect models were used to interpret collected observations. All statistical analysis performed using R developed by R core team.
Results: The preliminary analysis of observations showed that mean level of noise varied from 65 to 71 dBA among ICUs under study. Noise levels during the day were slightly higher than that of were observed during the night. Descriptive analysis of observations showed no major differences between the noise levels over the time and between the days/nights. Fitting a mixed-effects model showed significant differences of the noise levels between ICUs (P< 0.001).
Conclusion: We found the noise levels were always above the EPA thresholds at all three hospitals both during the day and night. It is recommended to train hospital officials and staffs for keeping noise levels to an acceptable level.
Mahboobeh Shirazi , Fatemah Azadi , Mamak Shariat , Shirin Niromanesh , Mahmoud Shirazi,
Volume 74, Issue 7 (October 2016)
Abstract
Background: There are evidences that suggest the impact of stress on pregnancy outcome. Prolong antenatal depression and anxiety may cause lots of adverse pregnancy outcomes such as abortion, still birth, low birth weight and preterm labor. The aim of this pre-posttest randomized control trial study was to determine the role of stress management training in the first trimester on stress reduction in pregnant women referring to General Yas Women Hospital related to Tehran University of Medical Sciences in Tehran, Iran, from May 2014 to January 2016.
Methods: Anxiety status of 75 pregnant women in the first trimester was assessed by standard anxiety questioner using Hamilton anxiety rating score. Scores 18-25, 25-35 and >35 were considered for mild, moderate and severe anxiety, respectively. According to the level of anxiety, women with moderate and severe anxiety as the interventional group were arranged for participation in stress management workshops, applying mindfulness technique including: body scan, setting meditation and passing thought technique in 5 an hour sessions. For this experimental group were made available CD training for practicing lessons during the week. All groups didn’t need to medical treatment according to the psychiatrist interview. In the ending of therapy, clinical groups were assessed by anxiety scale again. Women with mild anxiety as the control group received only regular prenatal care without any psychological interventions. The validity and reliability of questioner were approved by experts in this field. This research was supported by Tehran University of Medical Sciences and Health Services grant and also the study approved by ethics committee of Tehran University of Medical Sciences. Data were analyzed using the statistical software SPSS version 18, and Student’s t-test analyses were performed.
Results: The level of anxiety and stress was decreased significantly between women in clinical groups, 27.5 to 14.1 for moderated level stress (P= 0.001) and 40.1 to 16.6 for high level of stress (P= 0.0001) respectively.
Conclusion: First trimester of pregnancy is a crucial stage of fetal growth and development. Based on our findings, stress management training in this period has beneficial effects on stress reduction and enhances maternal health status.
Mahboobeh Shirazi , Nafiseh Saedi , Mamak Shariat , Fatemah Azadi , Fatemeh Davari Tanha ,
Volume 74, Issue 8 (November 2016)
Abstract
Background: Different treatment used for resolving menopausal problems. Some studies assayed effectiveness of citalopram but it had some side effects and other studies about medicinal plants in Iran, including Melissa (combination of officinalis and foeniculum vulgare) showed improvement insomnia and anxiety. This study decided to assay effectiveness of this drug and comparison with placebo and citalopram in treatment of sleep disturbance of menopausal women.
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Methods: Sixty postmenopausal women suffering from sleep disturbances that referred to Yas hospital between 2011-2013 were recruited to this double blind controlled study with 8 weeks’ follow-up period. They were randomized in three groups of twenty patients each, group A: received Melissa 600 mg that made by traditional medical school, group B: received citalopram 20 mg from Arya company that increased to 30 mg after one week and group C: received placebo. The patients were evaluated by Pittsburgh Sleep Quality Index (PSQI) questionnaire before and after treatment, also we checked the side effects of every drugs. Study was dissertation of one of the author with code 22263. This research has been supported by Tehran University of Medical Sciences and Health Services Grant. This study was registered at Iranian Registry of Clinical Trials with code of IRCT2013072714174N1.
Results: Pittsburgh sleep quality index improved significantly in all groups, there was significant differences between Melissa group and two other group, but there wasn’t significance difference between citalopram and placebo group, there was a trend in favor of Melissa versus citalopram and placebo. All of seven field of PSQI improved significantly in all groups that showed improvement of sleep quality in all field of sleep disturbance.
Conclusion: Melissa (compound of officinalis and foeniculum vulgare) may be recommended for the treatment of sleep disturbances in postmenopausal women. Although further investigation with more cases is needed to find long-term results and compare with hormone therapy.
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Mostafa Hosseinabadi, Mojtaba Kamyab, Fatemeh Azadinia, Javad Sarrafzadeh,
Volume 77, Issue 3 (June 2019)
Abstract
Background: The back extensor muscles are the main spinal supportive factors which function establishes spinal stability and erect posture of the spine. Spine deviation from the ideal alignment, like abnormal increase in the forward curvature of the thoracic spine may cause changes in the trunk muscle activity which can lead to a change in the spinal proprioception. It seems that the corrected spinal alignment as a result of an orthotic treatment course facilitates the back muscles activity and improve proprioception. The present study aimed to investigate the changes occurring in thoracic kyphosis, trunk extensor muscle strength and trunk extensor force sense after using the Spinomed orthosis in elderly people with hyperkyphosis.
Methods: Twenty-six elderly people with hyperkyphosis who met the eligibility criteria participated in this preliminary study at School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran, from August to November of 2017. Subjects were randomly allocated to the experimental (wearing the orthosis with maintaining the daily physical activities) and control (maintaining daily physical activities) groups. Degree of kyphosis, absolute error of force sense and trunk extensor muscle strength were measured in all participants before and after intervention for 9 weeks.
Results: Thirteen elderly people with 63.85±4.63 years old in the experimental group and thirteen elderly people with 66.92±3.25 years old were participated in data analysis. The results showed significant reduction in degree of kyphosis (P<0.001) and absolute error of force sense (P=0.001), and improvement of trunk extensor muscle strength (P=0.021) in the experimental group. Independent t-test results showed a significant difference between experimental and control groups with better outcomes in terms of posture correction (P<0.001) strength (P=0.002) and force sense (P=0.035) in the orthosis group.
Conclusion: Using Spinomed orthosis for 2 months (2 hours per day) appears to have some benefit in terms of back extensor muscle strength and muscle force control. Also, Spinomed orthosis can be prescribed to improve spinal posture.
