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Showing 3 results for Dabidi Roshan
The interactive effects of two forced and voluntary exercise training method and Nanocurcumin supplement on doxorubicin-induced hepatotoxicity in aging induced by D-galactose
Saied Kamal Sadat-Hoseini , Valiollah Dabidi Roshan ,
Volume 74, Issue 11 (February 2017)
Abstract

Background: Doxorubicin (DOX) is a commonly used chemotherapeutic agent that causes hepatotoxicity via depletion of anti-oxidants and activation of apoptosis. Present study was aimed to investigate the interactive effects of two forced treadmill running and voluntary wheel running exercise training method and Nanocurcumin supplement on hepatic damage, in aging model subjects.

Methods: This experimental research was performed in animals and exercise physiology laboratory of Faculty of Physical Education and Sport Sciences, University of Mazandaran, Iran, in April, 2014. The statistical population was eighty Wistar male rats that, received a daily injection of D-galactose solution for nine weeks (100 mg/kg body weight per day, i.p.) and then, they randomly assigned to 10 groups. The forced treadmill running protocol was progressively between 25 to 54 min/day at the intensity of 15 to 20 m/min for 5 days per week for six weeks and voluntary wheel running exercise was six weeks. DOX was administrated for 15 days (1 mg/mL/kg body weight per day, i.p.). Nanocurcumin supplement was administrated for 14 days (100 mg/kg body weight per day. orally). Superoxide dismutase and apoptosis inducing factor levels were measured by enzyme-linked immunosorbent assay (ELISA) method.

Results: Implementation of two forced treadmill running and voluntary wheel running exercise with Nanocurcumin supplement, respectively led to insignificant decrease and increase in superoxide dismutase levels in comparison with the implementation of this exercise methods alone (P= 0.955 and P= 1.000, respectively). Apoptosis Inducing Factor levels following these two training method with Nanocurcumin supplement, has insignificant decrease in comparison with the implementation of this exercise methods alone (P= 1.000 and P= 1.000, respectively).

Conclusion: Our findings suggest that, however implementation of these training methods with Nanocurcumin supplement, partly mitigates the side effects of doxorubicin, but this level of intervention is not sufficient to protect against doxorubicin-induced hepatotoxicity in aging model rats.

The impact of high-intensity interval training (HIIT) combined with berberine supplementation on hematological parameters in middle-aged men with pre-diabetes: a randomized controlled trial
Mehdi Nikseresht, Valiollah Dabidi Roshan , Khadijeh Nasiri,
Volume 81, Issue 10 (January 2024)
Abstract
Background: Exercise programs can lead to different physiological adaptations, but the effects of low-volume, low-frequency HIIT protocols with varying interval structures have not been thoroughly investigated. This study aimed to explore the impact of HIIT with high compression (HC) and low compression (LC), with or without berberine (BBR) supplementation, on hematological parameters in pre-diabetic men.
Methods: This semi-experimental study was conducted between October and December 2021 at Mazandaran University. Fifty-four overweight/obese men with a mean age of 48.6±6.6 years, a body mass index of 30.7±7.3 kg/m², and a body fat percentage of 34.4±4.3% were randomly and equally divided into one of six groups: HC, LC, HC+BBR, LC+BBR, BBR, and control. The HC group (2:1 work-to-rest ratio) and LC group (1:1 work-to-rest ratio) underwent training programs comprising 2-4 sets of 8 exercises at an intensity of 80-95% of their maximum heart rate twice a week for 8 weeks. Hematological responses to Bruce's incremental exercise test were measured before and after the intervention. Data were analyzed using a two-way ANOVA with Bonferroni's post hoc test, with a significance level set at P<0.05.
Results: Baseline hematological indices showed no significant differences between pre-diabetic and non-diabetic groups (all, P>0.05). Following the 8-week intervention, there were significant decreases in white blood cells (WBCs) in the LC and LC+BBR groups, and in lymphocytes across all intervention groups except BBR (all, P<0.05). Additionally, hemoglobin and hematocrit levels showed significant reductions in the HC and HC+BBR groups (both, P<0.05). However, in response to Bruce's incremental exercise test, a significant decrease in WBCs was observed in the LC and LC+BBR groups, with reductions of 18% and 25%, respectively (both, P<0.05).
Conclusion: The LC protocol, even without berberine supplementation, seems to provide better immunological benefits and result in less hemolysis compared to the HC protocol, as evidenced by reductions in white blood cell counts.

The effectiveness of intermittent Nordic exercises with and without VR on body composition and cardiorespiratory fitness in boys with internet addiction
Nima Nejati Boushehri , Valiollah Dabidi Roshan ,
Volume 81, Issue 12 (March 2024)
Abstract
Background: Being sedentary due to internet addiction is a common public health problem that causes overweight and obesity. Novel methods are needed for weight control behaviors. This study aimed to determine effects of short-term (two weeks) and moderate-term (four weeks) of virtual reality (VR) exercise program with and without interval Nordic walking (INW) in adolescent boys on novel body composition and maximal oxygen uptake (VO2max) parameters; body adiposity index (BAI), abdominal volume index (AVI), conicity index (CI), waist-to-height ratio (WHtR), and a body shape index (ABSI).
Methods: In a semi-experimental trial during July to December 2023, 70 adolescent boys (age 14.8 years, body mass index (BMI)=24.4 kg/m2 and VO2max 38 ml/kg/min) with the Young IA tests score ranging over five, were selected from the city of Karaj and randomly was classified to VR, INW, VR+INW and control groups. Individual and combined exercise programs of VR and INW were performed (three session in week for 30 min) for two and or four weeks. The parameters were evaluated at the baseline and the follow up phases (two and four weeks after the interventions period) with a repeated measure ANOVA.
Results: According to Young's internet addiction test scores at the beginning of the study, there was no significant difference between the control and intervention groups (P≥0.05). It has been observed that internet addiction negatively affects cardiorespiratory fitness. When a 2-week intervention of VR exercises was implemented along with INW, the improvement in cardiorespiratory fitness (VO2max) was better than when VR exercises alone lasted for four weeks (P≤0.05). After four weeks of INW intervention, separately and in combination with VR, a significant improvement was observed in VO2max, WHtR and BAI values compared to the control group (P≤0.01).
Conclusion: Although improvement in cardiorespiratory fitness of boys with IA can be achieved by doing short and medium term INW, VR and INW+VR exercises, longer interventions, i.e., four weeks or more, cause more significant changes in the novel body composition.

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