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Showing 2 results for Derakhshan Deilami Gh

Derakhshan Deilami Gh, Mehrabi S,
Volume 58, Issue 2 (7 2000)
Abstract

Despite the role of oral corticosteroids in management of sever asthma, use of these drugs needs careful awareness of its many side effects. There are controversies about the role of methotrexate in lowering the need for corticosteroides in these patients. In this study an attempt has been made to determine methotrexate effects in corticosteroid dependent asthma. Six patients were entered in a double-blind placebo controlled crossover trial and randomly allocated to two groups. Each group got a 12 weeks course of treatment with 15 milligrams of methotrexate or placebo which thereafter was changed to the other regimen. In comparison with placebo, methotrexate caused a 62.5% less need for oral corticosteroid (P<0.01) and a 20% increase in FEV1 (P<0.05). We concluded that the use of low doses of oral methotrexate results in less need for oral corticosteroid in treatment of corticosteroid dependent asthma.
Firooz Bakhsh Sh, Safavi E, Zahed Poor Anaraki M, Derakhshan Deilami Gh ,
Volume 60, Issue 4 (15 2002)
Abstract

Background: Transbronchial lung biopsy (TBLB) is an attractive alternative to open lung biopsy as an initial diagnostic procedure for patients with diffuse parenchymal disease or localized densities beyond direct endoscopic vision. TBLB can be carried out safely without fluoroscopy in patients with diffuse lung disease. Since in our bronchoscopic department fluoroscopy is not available, we planned to evaluate the blind (without fluoroscopic guide) TBLB being performed in our department to determine the success rate in obtaining lung tissue, the sensitivity of the procedure and the risk of complications.

Materials and Methods: Sixty-four TBLB were done in our department during a six month period (March-September 1999).

Results: Lung tissue wasn't detected in two (3.1 percent) samples. Pathological results were helpful in 46 (71.9 percent) cases. No evidence of hemoptysis was found after the procedure. Three (4.68 percent) cases of pneumothorax were detected. Only one of them required chest tube (1.51 percent).

Conclusion: We concluded that blind TBLB was successful in our department with rates of complications comparable to other approved centers.



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