Showing 6 results for Esmati
F. Amoozegar Hashemi, F.razi, E.esmati, M.sajjadi,
Volume 64, Issue 5 (1 2006)
Abstract
Background: High titer of IgA and IgG are found in the presence of EBV genome in epithelial cells of nasopharyngeal carcinoma. In this survey we evaluated the accuracy of EBV antibodies titers in screening and follow up the patients.
Methods: Thirty nasopharyngeal carcinoma patients were followed from 2003 to 2004. Serum EBV antibody levels were measured before and after ( 3 months ) radiotherapy or combined radiotherapy and chemotherapy.
Results: More than 77% of patients were seropositive before treatment .The antibodies decreased significantly, 3 months after treatment (p<0.05).
Conclusion: This investigation shows the efficiency of serologic methods for screening of high risk people and follow up of patients after treatment, but more complementary studies is needed
Amouzegar Hashemi F, Esmati E, Kalaghchi B,
Volume 65, Issue 11 (1 2008)
Abstract
Background: Carcinoma of the uterine cervix is the sixth most common malignant neoplasm in women. Early stage diagnosis of uterine cervix carcinoma increases the cure rate of disease. Radiotherapy, with or without concurrent chemotherapy, is one of the most effective treatment modality in cervical carcinoma. After radiotherapy, accurate and regular follow-up results in early diagnosis and effective treatment of recurrence. The aim of this study is the assessment of the pathologic characteristics, setting and indications for postoperative radiotherapy and outcome of patients at the last follow-up.
Methods: In this retrospective study, we evaluated 346 cases of cervical carcinoma had received radiotherapy in radiation oncology department of the Cancer Institute of Imam Khomeini Hospital, Tehran, Iran, from 1995 to 2001.
Results: The age of the study group ranged from 26 to 78 years (mean=50.5, SD=11). Of these patients, 30.4% were in the early stage and 69.6% had advanced stage disease. Squamous cell carcinoma comprised 92.2% of the cases and 6.4% adenocarcinoma. Radical radiotherapy was the most frequent radiotherapy setting and adjuvant radiotherapy (post-op) was the second. A considerable number of patients did not come back for follow-up, and 43.7% were followed for a short time.
Conclusion: Accurate presurgical clinical staging and surgical treatment by an expert gynecologic oncologist can reduce expose the patients to risks of two modality treatments (surgery and radiotherapy). According to our results, patients do not pay enough attention to disease follow-up. An acceptable training plan with emphasis on regular follow-up, is recommended.
Mahdi Aghili , Maryam Moshtaghi , Farhad Samiee , Ebrahim Esmati , Mahbod Esfahani , Hasan Ali Nedaee , Peiman Haddad ,
Volume 68, Issue 8 (November 2010)
Abstract
Background: The current standard of adjuvant management for gastric cancer after curative resection based on the results of intergroup 0116 is concurrent chemoradiation. Current guidelines for designing these challenging fields still include two-dimensional simulation with simple AP-PA parallel opposed design. However, the implementation of radiotherapy (RT) remains a concern. Our objective was to compare three-dimensional (3D) techniques to the more commonly used AP-PA technique.
Methods: A total of 24 patients with stages II-IV adenocarcinoma of the stomach were treated with adjuvant postoperative chemoradiation with simple AP-PA technique, using Cobalt-60. Total radiation dose was 50.4Gy. Landmark-based fields were simulated to assess PTV coverage. For each patient, three additional radiotherapy treatment plans were generated using three-dimensional (3D) technique. The four treatment plans were then compared for target volume coverage and dose to normal tissues (liver, spinal cord, kidneys) using dose volume histogram (DVH) analysis.
Results: The three-dimensional planning techniques provided 10% superior PTV coverage compared to conventional AP-PA fields (p<0.001). Comparative DVHs for the right kidney, left kidney and spinal cord demonstrate lower radiation doses using the 3D planning techniques (p<0.0001), the liver dose is higher (p=0.03), but is still well below liver tolerance.
Conclusion: Despite the department protocol using conventional planning, 3D radiotherapy provides 10% superior PTV coverage. It is associated with reduced radiation doses to the kidneys and spinal cord compared to AP-PA techniques with the potential to reduce treatment toxicity.
Amouzegar Hashemi F, Hamed Akbari E, Kalaghchi B, Esmati E,
Volume 69, Issue 9 (6 2011)
Abstract
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Background: More than 80 years, the standard treatment of locally advanced cervical
cancer was radiotherapy. However, based on several phase III randomized clinical trials in the past decade, concurrent
cisplatin-based chemoradiotherapy is the current standard of treatment for this
disease. Gemcitabine has potent radiosensitizing properties in preclinical and
clinical trials, so it can be utilized simultaneously with radiation.
Methods: Thirty Women with untreated invasive
squamous-cell carcinoma of the cervix of stage IIB to stage IVA were enrolled in the study in
Radiation Oncology department of Imam Khomeini Hospital in Tehran from
September 2009 to September 2010. Sixty mg/m2 gemcitabine followed by 35 mg/m2 cisplatin were
concurrently administered with radiotherapy to the whole pelvic region on day
one of each treatment week for five weeks One and three months after treatment,
patients underwent a complete physical examination and MRI to determine the response to treatment.
Results: The mean age of the participants was 58.13±11.83 (29-78) years. After 3 months of treatment, 73.3%
had complete and 26.7% had partial response to treatment.
Grade 3 anemia was seen in 10%, grade 3 thrombocytopenia in 3.3% and grade 3
leukopenia in 10% of the patients.
Conclusion: According to the positive results of this study in
stage IIB,
further phase II
and III
clinical trials are suggested to evaluate the role of chemoradiation by
gemcitabine in advanced cervical cancers.
Samiei F, Maddah Safai A, Esmati E, Alibakhshi A, Mirai Ashtiani Ms, Haddad P,
Volume 70, Issue 7 (6 2012)
Abstract
Background: Gastric cancer is an important health problem across the world. Chemotherapy in combination with local treatment is the standard treatment for locally advanced gastroesophageal junction (EGJ) cancers. The purpose of this study was to evaluate response and tolerability to neoadjuvant regimen combining epirobicin, oxaliplatin and capecitabin (EOX) in locoregionally advanced gastric cancer.
Methods: We recruited 28 patients with histologically confirmed advanced gastric or EGJ adenocarcinoma in this study performed in the Cancer Institute of Imam Khomeini Hospital in Tehran, Iran in 2010-2011. Staging workup included chest and abdominal computed tomography (CT) scans, upper gastrointestinal endoscopy, endoscopic ultrasonography (EUS), measurement of carcinoembryonic antigen (CEA), complete blood cell count (CBC), and liver and renal function tests. After three treatment cycles with EOX regimen, we evaluated response to the neoadjuvant chemotherapy by performing endoscopic ultrasonography (EUS) and chest and abdominal CT scans.
Results: The mean age of the patients was 56.64±11.08 years (ranging from 37 to 78 years). Most patients were classified as having stage III (98.8%) cancer before chemotherapy while most were classified as stage II (57.14%) after the treatment. Only 28.5% of tumors were resectable before chemotherapy, but 82.1% of them were resectable upon the treatment. 75% of tumors were downstaged after chemotherapy.
Conclusion: Regarding the acceptable response and downstaging of tumors and low toxicity of EOX regimen in locoregionally advanced gastric cancer, evaluation of this regimen as a neoadjuvant chemotherapy in larger phase III clinical trials in Iranian patients would be both necessary and logical.
Mehdi Mohebi , Khalil Pourkhalili , Mahnaz Kesmati , Samad Akbarzadeh , Zahra Akbari ,
Volume 72, Issue 3 (June 2014)
Abstract
Background: Anabolic-Androgenic Steroids (AAS) are mainly abused by athletes for improvement of muscle performance. Data suggest that the effect of AAS on neurobiochemicals related to behavioral response, may be underlies psychological adverse effects. Physical activity has beneficial psychophysiological effects, which may be related to increased serum levels of endogenous opioid peptides during exercise. In the present study we aimed to study the effect of chronic administration of nandrolone decanoate on beta-endorphin and met-enkephalin level in exercising rats.
Methods: In this experimental study, forty male Wistar rats were randomly assigned in two main groups of sedentary and trained (2 weeks swimming exercise). Animals in each group were divided in two subgroups of control (received nandrolone solvent) and drug treatment (received nandrolone 15 mg/kg, 5 times/week). After two weeks of swimming exercise and drug treatment, serum levels of beta-endorphin and met-enkephalin were measured using ELIZA.
Results: Our data showed that two weeks of swimming exercise training significantly increased serum beta-endorphin (114±5 vs. 98±5 ng/l in control group, P= 0.038) and met-enkephalin levels (1556±42 vs. 1475±27 ng/l in control group, P= 0.25). However, chronic administration of nandrolone decanoate in trained group considerably de-creased beta-endorphin (84±4 vs. 114±5 ng/l in control group, P= 0.002) and met-enkephalin levels (1378±36 vs. 1556±42 ng/l in control group, P= 0.011). The effect of supraphysiologic doses of nandrolone decanoate in control sedentary group was not statistically significant.
Conclusion: In the present study we show that chronic nandrolone decanoate admin-istration attenuates effects of two weeks swimming exercise on serum opioid peptide and reduces the level of beta-endorphin and met-enkephalin. Keeping in mind that opi-oidergic system play an important role in behavior, athletes abusing anabolic steroid drugs may potentially experience changes in mood and behavior.
