Tehran University Medical Journal

---

Because of high prevalence of upper limbs pain and carpal tunnel sndrome and the need of proofing of diagnosis by nerve conduction study (NCS) testing of edian nerve is one of the most common exams in electro-diagnostic centers. In interpretation of findings of nerve conduction study presence of a normal range for findings is one of the most important points.
Materials and Methods: In this study we obtained the findings of nerve conduction study of median nerve in 60 normal persons.
Results: The mean of motor distal latency was 3.09 ms (SD: 0.35). The mean of sensory distal latency measured to peak of response was 3.04 ms (SD: 0.28) with increasing age mean of motor and sensory distal latencies increased. Most of findings had no significant difference with other references.
Conclusion: There is no problem in using of the normal ranges of the other countries for Iranian patients.

---

Background: Nonlethal genetic damage is the basis for carcinogenesis. As various gene aberrations accumulate, malignant tumors are formed, regardless of whether the genetic damage is subtle or large enough to be distinguished in a karyotype. The study of chromosomal changes in tumor cells is important in the identification of oncogenes and tumor suppressor genes by molecular cloning of genes in the vicinity of chromosomal aberrations. Furthermore, some specific aberrations can be of great diagnostic and prognostic value. Comparative genomic hybridization (CGH) is used to screen the entire genome for the detection and/or location chromosomal copy number changes.

Methods: In this study, frozen sections of 20 primary breast tumors diagnosed as invasive ductal carcinoma from the Cancer Institute of Imam Khomeini Hospital, Tehran, Iran, were studied by CGH to detect chromosomal aberrations. We compared histopathological and immunohistochemical findings.

Results: Hybridization in four of the cases was not optimal for CGH analysis and they were excluded from the study. DNA copy number changes were detected in 12 (75%) of the remaining 16 cases. Twenty-one instances of chromosomal aberrations were detected in total, including: +1q, +17q, +8q, +20q, -13q, -11q, -22q, -1p, -16q, -8p. The most frequent were +1q, +17q, +8q, -13q, similar to other studies. In three cases, we detected -13q, which is associated with axillary lymph node metastasis and was reported in one previous study. The mean numbers of chromosomal aberrations per tumor in metastatic and nonmetastatic tumors was 1.5 and 1, respectively. No other association between detected chromosomal aberrations and histopathological and immunohistochemical findings were seen.

Conclusion: Since intermediately to widely invasive carcinomas are more likely to have chromosomal aberrations, CGH can be a valuable prognostic tool. Furthermore, CGH can be used to detect targeting molecules within novel amplifications which holds the potential for a new therapeutic approach for intractable cancer.