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Showing 6 results for Ghafouri
Four port-sites metastasis of gallbladder cancer after laparoscopic cholecystectomy: a case report
Ghafouri A, Nasiri Sh, Karam Nejad M, Farshidfar F,
Volume 66, Issue 7 (6 2008)
Abstract

Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Background: Port-site metastasis following laparoscopic cholecystectomy with unsuspected gallbladder carcinoma is a serious problem. Gallbladder carcinoma is found in 1% of all biliary tract operations, in most being diagnosed only after histological examination of the gallbladder. The spread of cancer following laparoscopy appears aggressive and widespread, as noticed from re-operation for radical treatment. The pathologic findings of gallbladder were consisting of tumoral and necrotic tissue, indicating of well differentiated adenocarcinoma. Mucosa and submucosa were involved, but no evidence of invasion to muscular layer and gall bladder serosa was found (T1). In this article we present the first of an unusual case of four port site adenocarcinoma metastasis from gallbladder cancer.
Case report: A 63 year old woman underwent laparoscopic cholecystectomy for acute cholecystitis. Thirty months later, she was admitted to the hospital with a complaint of masses at the four trocar sites. A biopsy from the port sites was undertaken and led to the diagnosis of adenocarcinoma metastasis. There is no published report of all four port site metastasis of gallbladder cancer after laparoscopic cholecystectomy.


Vagus nerve schwannoma presenting with dysphagia and prolonged cachexia: a case report
Ali Ghafouri, Zhamak Khorgami, Saadat Moulanaei,
Volume 67, Issue 12 (6 2010)
Abstract

Background: Intraabdominal schwannomas are rare tumors mostly occur in patients with neurofibromatosis. Tumors arisen from vagus nerve are rarer especially in sporadic cases. 

Case: A 34-year-old man admitted in surgery ward Milad Hospital, in Tehran, Iran with long-lasting vomiting, dysphagia, and cachexia for four years. Multiple previous paraclinical assessments were normal, he had been treated as anorexia nervosa for three years without improvement. Our evaluations showed a mass in diaphragmatic hiatus. Explorative laparotomy revealed a mass parallel to distal esophagus, which was resected completely. Immunohistochemical examinations revealed a benign schwannoma. After surgery, the patient&aposs symptoms recovered and he returned to normal life.

Conclusions: Vagus nerve schwannoma can present with dysphagia and cachexia with normal endoscopic evaluations. It is important to rule out physical causes in patients with cachexia who are treated with psychiatric diagnoses.


Isolation and identification of Nocardia asteroids complex isolated from thigh abscess in a patient with Behçet's syndrome: the first report from Iran
Seyyed Saeed Eshraghi , Mehdi Fatahi Bafghi , Ali Ghafouri , Parvin Heidarieh , Shadi Habibnia , Masoumeh Rasouli Nasab , Hojat Yazdanbod , Hosein Keshavarzi ,
Volume 71, Issue 7 (October 2013)
Abstract
Background: Nocardia species are Gram-positive, partially acid fast, non-motile, catalase positive, aerobic and saprophytic actinomycetes found all around the world. They invade the human body from the environment via trauma and respiratory tract and cause cutaneous, pulmonary and systemic diseases. They are able to grow in various media.The organisms opportunistically infect both immunocompromised and immunocompetent individuals. Behcet's disease is an autoimmune disease and immunocompromised patient which may suitable host for Nocardia bacterium. The present study is the first case report of isolation of Nocardia from the thigh abscess in a patient with behcet’s disease from Iran.
Case Presentation: A 39-year-old man with Behcet’s disease in August 2011 was admitted to Shariati hospital Tehran, with swelling and pain in the left flank and left thigh. Microscopic identification from direct microbiological slide of thigh abscess discharge demonstrated number of lymphocytes, neutrophils and macrophages foamy and white blood cells together with filamentous bacteria. Further microbiological characterization using phenotypic and antibiogram tests with disk diffusion method, demonstrated that the isolated bacterium is Nocardia asteroides complex. The bacteria were sensitive to ampicillin, vancomycin, ceftriaxone, amikacin and cotrimoxazole but it was resistant to clindamycin, erythromycin, penicillin G, cephalothin and gentamicin. The patient was treated with cotrimoxazole.
Conclusion: Because of the high incidence and high mortality of Nocardia infection in immunocompromised cases, rapid detection and timely treatment for these patients is necessary.

Autosomal recessive polycystic kidney disorder due to two novel compound heterozygote mutations in PKHD1 gene: case report
Mohammad Miryounesi , Majid Fardaei , Seyyed Mohammad Bagher Tabei, Soudeh Ghafouri-Fard ,
Volume 74, Issue 10 (January 2017)
Abstract

Background: Autosomal recessive polycystic kidney disorder (ARPCKD) is one of the most prevalent hereditary disorders in neonates and children. Its frequency is between 1/6000 to 1/55000 births. In the most severe cases, it can be diagnosed prenatally by the presence of enlarged, echogenic kidneys and oligohydramnios. However, in the milder forms, clinical manifestations are usually detected in neonatal and childhood period. PKHD1 gene located on chromosome 6 is linked with this disorder. About half of detected mutations in this gene are missense ones. The largest protein product of this gene is called the FPC/polyductin complex (FPC). It is a single-membrane spanning protein whose absence leads to abnormal ciliogenesis in the kidneys.

Case presentation: Here we present a 5-year-old female patient affected with ARPCKD. She has been born to a non-consanguineous healthy Iranian parents. No similar disorder has been seen in the family. Prenatal history has been normal. In order to find the genetic background, DNA was extracted from patient's peripheral blood lymphocytes. PKHD1 gene exons and exon-intron boundaries were sequenced using next generation sequencing platform. Two novel variants have been detected in compound heterozygote state in the patient (c.6591C>A, c.8222C>A). Bioinformatics tools predicted these variants to be pathogenic.

Conclusion: In the present study, we detected two novel variants in PKHD1 gene in a patient with ARPCKD. The relatively mild phenotype of this patient is in accordance with the missense mutations found. Molecular genetic tools can help in accurate risk assessment as well as precise genotype-phenotype correlation establishment in families affected with such disorder to decrease the birth of affected individuals through preimplantation genetic diagnosis or better management of disorder.

Mental retardation due to chromosomal translocation in an Iranian consanguineous family: report of three cases
Soudeh Ghafouri-Fard , Mehdi Dianatpour , Seyed Mohammad Bagher Tabei, Mohammad Miryounesi ,
Volume 74, Issue 11 (February 2017)
Abstract

Background: Mental retardation is defined as impaired mental capacity and ability to comply with environmental and social conditions. Chromosomal abnormalities are the most important causes of mental retardation. Carriers of balanced chromosomal translocation are phenotypically normal, although they may be at risk of infertility, recurrent miscarriage or giving birth to mentally retarded children. These abnormalities are caused because chromosomes participated in the reciprocal translocations produce quadrivalents at meiosis. These quadrivalents segregate and lead to several different meiotic outcomes, just two of which are normal or balanced.

Case Presentation: A consanguineous family with three mentally retarded daughters at the ages of 24, 18 and 10 years was referred to Comprehensive Medical Genetics Centre, Shiraz, Iran in 2015. Family history showed a case of unexplained infant death as well as a spontaneous abortion. Three survived siblings had hypotonia and severe developmental delay during infantile period. In addition, they suffer from primary amenorrhea. Two siblings have vesicoureteral reflux (VUR). Cytogenetic analysis of two patients showed 46,XX,t(6;12)(q23;q22),der(9)t(8;9)(q24;p24) with partial monosomy of chromosome 9 and partial trisomy of 8q24 segment, while the other patient had 46,XX,der(12)t(6;12)(q23;q22) with partial monosomy of 12q22qter and partial trisomy of 6q23qter segment. Their mother had two balanced chromosomal translocations (46, XX, t(6,12)(q21;q22), t(8,9)(q24;p24)).

Conclusion: The above presented case is another example for the rare occurrence of double balanced chromosomal translocations in a phenotypically normal person. Although the most important causes of mental retardation in consanguineous marriages are autosomal recessive disorders, the role of chromosomal aberrations in mental retardation in these families must not be neglected. In other words, cytogenetic studies should be performed as a first line test in either situation.

Modeling and design of a diagnostic and screening algorithm based on hybrid feature selection-enabled linear support vector machine classification
Tara Ghafouri, Negin Manavizadeh,
Volume 80, Issue 7 (October 2022)
Abstract
Background: In the current study, a hybrid feature selection approach involving filter and wrapper methods is applied to some bioscience databases with various records, attributes and classes; hence, this strategy enjoys the advantages of both methods such as fast execution, generality, and accuracy. The purpose is diagnosing of the disease status and estimating of the patient survival.
Methods: Feature selection algorithms have been modeled in Matlab R2021a during April and May 2022 in the framework of statistical pattern recognition. First, the features are ranked based on normalized mutual information, as a metric of relevance and redundancy of features, and accordingly, an optimum feature subset with the highest accuracy of classification is selected. Two feature selection algorithms, i.e., inclusion of features enhancing the classification accuracy and exclusion of irrelevant features are applied to the interest datasets, subsequent to the mini-batch k-means clustering of records.
Results: At the end of the execution of both feature selection methods, evaluation metrics including accuracy, precision, recall, and F1 score are measured and compared. Both proposed feature selection approaches for the molecular biology, hepatitis C virus (HCV), and E. coli bacteria datasets result in the precision and recall scores more than 98 percent, meaning that there are few false positives and false negatives in the linear support vector machine (LSVM) classification. Regarding the HCV dataset, selection of nine relevant features among the thirteen present ones using the feature exclusion method yields the classification accuracy and F1 score of 98.92 percent and 99.02 percent, respectively. The feature inclusion approach also results in an accuracy of 98.78 percent with a slight discrepancy.
Conclusion: The results reveal superior strength of the feature selection methods used here for life science datasets with higher-order features such as protein/gene expression database. The potentials to generalize to other classifiers and automatically specify the optimal number of features during the feature selection procedure make these approaches flexible in many data mining applications for the life sciences.

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