Showing 5 results for Haeri H
Asadi Amoli F, Haeri H,
Volume 58, Issue 3 (7 2000)
Abstract
Despite many advances in the field of cancer treatment, intra-cranial tumor cases still have a poor prognosis. This research has been carried out in order to describe age and sex distributions and histopathological characteristics and site of intra-cranial tumors. We studied 425 patients with intra-cranial tumor whose samples were examined in pathology center of Imam Khomeini hospital from 1991 to 1996. The commonest types of tumors in our study were glial (28%) tumors and meningioma (27.76%). The commonest sites of tumors were cortex (30.6%), hypophysis (21.89%), and cerebellum (15.3%). Among metastatic tumors of the brain, thyroid carcinoma was the most prevalent one (55.5%). The results of this study did not significantly contrast findings of other studies.
Javadi P, Haeri H,
Volume 59, Issue 4 (9 2001)
Abstract
Tumor angiogenesis shown by Microvessel Count (MVC) or Microvessel Density (MVD), is assessed by several studies as prognostic factor in some types of tumors, and also in colorectal carcinoma. This article is payed to correlation between clincopathologic factors and tumor angiogenesis. In this study, immunohistochemical techniques are used for vascular evaluation in specimens from twenty-nine colorectal carcinoma, and stained for Factor VIII-Related Antigen (F8RA) by using monoclonal antibody. Uni and multivariate analysis disclosed that total MVC was higher in tumor [76.3±33 (×100=2.5 mm²/field) and 29.8±11 (×200=0.785 mm²/field)] than in normal tissue [37.7±15.8 (×100) and 17.6±7.8 (×200)], (P=0.022, P=0.000009). Microvessel quantification was significantly higher in stage D (115±36.6, ×100 and 26.7±6.4, ×200, P=0.002 and P=0.04). In this study MVD has correlation with vascular invasion (P=0.024, ×100 and P=0.007, ×200), the mean tumor vessel count although was increased with clinicophatologic findings such as age<60 years, male, right colon involvement, infiltrating type, mucinous carcinoma, transmural penetration, grade III, lymphatic and perineural invasion, but was not statistically significant. Lymph node and hematogenous metastasis and size of tumor also, was not important. As a conclusion, MVD was increased in tumor and has shown correlation with metastasis, and vascular invasion. Resulting angiogenesis increase risk of metastasis.
Asadi Amoli F, Mohammadi S Z, Haeri H, Kasaei A,
Volume 61, Issue 2 (14 2003)
Abstract
There are few studies of eyelid's neoplasm in Asia which in comparison of references are some differences.
Materials and Methods: For this reason the retrospective study in 1103 patients which are referred to Farabi Hospital in 10 years period of 1988-1998 was performed. Epidemiological and histopathologic details were sough.
Results: 44 percent of the neoplasm were benign and 56 percent were malignant. The most prevalent benign neoplasm of eyelid respectively were Nevus (37.7 percent) hamartoma (19.6 percent) and papilloma (15.9 percent) and malignant neoplasm of eyelid respectively were basal cell carcinoma (78.7 percent), squamous cell carcinoma (11.8 percent ) and melanoma (2.4 percent ). The mean age in benign neoplasm was 36 years and in malignant ones 57 years, In benign tumors the most prevalent anatomical site respectively were upper eyelid, lower eyelid and inner canthus. But in malignant tumors it was occurred most frequently in upper eyelid in comparison to lower eyelid in addition occurrence of malignant tumors was prevalent in left but in benign neoplasm right and left eyelid were involved equally.
Motasaddi Zarandy M, Khorsandi M T, Senemar A, Shaeri H R,
Volume 65, Issue 3 (2 2007)
Abstract
Background: Hypothyroidism is a well-documented complication after treatment of laryngeal cancer and is particularly significant among patients undergoing laryngectomy. We investigated the frequency of hypothyroidism in patients treated with total laryngectomy for laryngeal cancer. We also evaluated the effect of neck radiotherapy on thyroid function after total laryngectomy for laryngeal cancer.
Methods: In a cross-sectional study, we evaluated 31 patients with laryngeal squamous cell carcinoma (mean age 53.6 years). Among these patients, 14 were treated with surgery only and 17 were treated with surgery plus radiotherapy. Laboratory evaluation included levels of thyroid stimulating hormone (TSH), free T4, free T3, and antithyroid antibodies both preoperatively and postoperatively at the first day, as well as one and six months after surgery.
Results: All patients had normal thyroid function before treatment however, after 6 months, five patients (16.1%) were hypothyroid. Of these, three patients (9.6%) had subclinical symptoms, including elevated thyroid-stimulating hormone with normal free T4, and two patients (6.5%) showed clinical symptoms of hypothyroidism. Radiotherapy and neck dissection were significantly associated with higher incidences of hypothyroidism.
Conclusion: Our data suggest that hypothyroidism occurs in a substantial proportion of patients undergoing surgery for laryngeal cancer. The results indicate that thyroid function studies should be routinely performed in the follow-up care of laryngeal cancer patients, especially if radiotherapy and neck dissection were part of the treatment. We suggest that this approach will improve the patient's quality of life and diminish the co-morbidity associated with this kind of surgery.
Izadi Mood N, Kororian A, Iravanloo G, Haeri H,
Volume 65, Issue 7 (4 2007)
Abstract
Background: Uterine sarcomas are malignant mesenchymal neoplasms that represent three to five percent of all uterine tumors, and are classified into three major groups: 1) mixed mullerian sarcoma 2) endometrial stromal sarcoma 3) leiomyosarcoma. The purpose of this study is to determine the association of different prognostic factors with patient survival and tumor relapse.
Methods: Twenty-seven patients with a previous diagnosis of uterine sarcoma were entered into this survival study. Inclusion criteria were presence of primary uterine tumor, confirmation of previous diagnosis in pathologic reassessment and availability for follow-up. We evaluated the association of overall and disease-free survival with eight factors, including FIGO stage, lymph node status, mitotic count per 10 high-power fields, vascular status, age, histology of sarcoma, myometrial depth of invasion and size of tumor.
Results: The median age of our patients was 47 years, ranging from 18 to 73 years, and median time of follow-up was 28 months, ranging from 1 to 114 months. Five-year survival was 61% and the mean time of overall survival was 78 months, with a 95% confidence interval, ranging from 56 to 100 months. LSS histology type, in contrast to other subtypes, and a mitotic count of 0-9, in contrast to 20 and more, were two factors that significantly related to relapse of tumor (p<0.05). The three factors related to survival were FIGO stage (p=0.0039), mitotic count (p=0.0005) and LSS histology type in contrast to other subtypes (p< 0.05). Relapse occurred mostly in the pelvic region or lung.
Conclusion: From our findings and a review of other reports, the FIGO stage is associated with survival, although other factors discussed in the literature are controversial. Some factors had been reported to have significant association only within a restricted histological subgroup. However, due to the limitation of our number of cases in each subgroup, we could not make such an analysis. Future studies with adequate numbers of samples are recommended.
