Showing 7 results for Hasibi
M. Hasibi, M. Mohraz, M. Haji Abdolbaghi, M. Rasouli Nejad, A. Bayat,
Volume 64, Issue 4 (1 2006)
Abstract
Background: Acute bacterial sinusitis is one of the most common causes for antibacterial treatment. Oral Penbactam (ampicillin- sulbactum or Sultamicillin) is a broad spectrum antibiotic and it has no significant side effect. To our knowledge, this is the first study in Iran in which, oral Penbactam has been prescribed for patients with acute bacterial sinusitis.
Methods: A randomized clinical trial was performed on 44 outpatients diagnosed with acute bacterial sinusitis in Amir- Aalam Hospital from March 2003-2004 to August 2004. Patients were randomized in 2 group: 23 to oral Penbactam (375 mg twice daily), and 21 to oral Co-amoxicolav (625 mg three times daily). Duration of treatment was 10 days for both groups.
Results: Both groups showed a significant clinical improvement after 10 days of treatment. In the Penbactam group, 19 of 23 (86.36%) and in the Co-amoxicolav group ,18 of 21 (85.71%) showed clinical improvement. In the Penbactam group, one patient (4.3 %) developed diarrhea and the medication was discontinued.
Conclusion: Oral Penbactam is an effective and safe antibiotic in the treatment of acute bacterial sinusitis and could be used as an alternative medication for acute bacterial sinusitis.
Hasibi M, Iravani Bm,
Volume 65, Issue 3 (2 2007)
Abstract
Background: Staphylococcus aureus is one of the most common causes of nosocomial infections with high morbidity and mortality rate. Traditionally, methicillin resistant staphylococcus aureus has been considered a major nosocomial pathogen in healthcare facilities, but in the past decade, it has been observed emerging in the community as well. Informations regarding hospital microbial colonization could be an important step for prevention of nosocomial infections. Our objective was clarifying the prevalence of methicillin resistant and vancomycin resistant staphylococcus aureus colonization in nasopharynx.
Methods: A descriptive cross sectional study was carried on 106 patients and nursing staff of surgery and hemodialysis wards in Amir-Alam hospital from April 2005 to July 2005. The samples were collected from nasal region of cases using cotton swab by two experienced technician and were sent to laboratory for culture and antibiogram.
Results: Twenty six (29.5%) out of 106 cases were nasopharyngeal carriers of staphylococcus aureus. Eight cases (7.5%) had methicillin resistant staphylococcus aureus. The most frequent colonization rate was seen in hemodialysis nursing staff and in all of them methicillin resistant staphylococcus aureus was reported. Carrier rates in hemodialysis patients were twice compared to surgery ward patients. The interesting point was that no sample of vancomycin resistant staphylococcus aureus was isolated.
Conclusion: Prevalence of methicillin resistant staphylococcus aureus colonization seems to be increased therefore proper management for controlling this problem is mandatory. The results of the present study suggest that the prevalence of methicillin resistant staphylococcus aureus infections is higher than was expected in Iran and vigorous preventive strategies should therefore be taken to stop the growth of this major health problem.
Hasibi M, Soudbakhsh A., Abadi Z, Mehdipoor P,
Volume 65, Issue 10 (2 2008)
Abstract
Background: Infectious diseases are usually treatable however, infectious disease is one of the most common causes of mortality in hospitals. Furthermore, an apparent functional stagnation around the weekends in hospitals can increase the mortality rate. The goal of this study is to describe the causes and predisposing factors of mortality and to evaluate the role of holidays on patient mortality in infectious disease wards.
Methods: In this retrospective descriptive-analytic study, we examined the files of patients who had expired while hospitalized in the infectious disease ward of Imam Khomeini Hospital from 2002 to 2004. All of the information was gathered from patient files and the mortality committee of Imam Khomeini Hospital. Patient mortality rates were determined for each year. Mortality rates for the various days of the week were estimated and compared for 2004.
Results: The total number of patients included in this study was 3979. Of these, 216 cases had expired, 143 of whom were male (66%). The common causes of mortality were sepsis (26%) bacterial pneumonia (22%) and tuberculosis (19%). The mortality rates were 5.08%, 5.31% and 5.84% in 2002, 2003 and 2004, respectively. In 2004, mortality rates were 9.21%, 10.21% and 4.56% for holidays, pre-holidays and other days of week, respectively. A significantly higher rate of mortality was observed for holidays and pre-holidays compared to the other days of week. (P value <0.05).
Conclusions: Fortunately, the mortality rate of 5.43% in this infectious disease ward was not high. Since sepsis, bacterial pneumonia and tuberculosis were the most common causes of mortality, extra care of patients with these diseases is necessary. As a result of the findings of this study, we recommend increasing expert hospital staff and improving the quality of diagnostic and treatment services during holidays and pre-holidays.
Abdolreza Soudbakhsh , Habibollah Mortazavi , Mahbobeh Hajiabdolbaghi , Mehrdad Hasibi , Sirous Jafari , Hamid Emadi Kochak, Esmaili Djavid,
Volume 67, Issue 6 (9-2009)
Abstract
Background: Finding a reliable diagnostic method for brucellosis is the most challengeable problem. In this study we determined the optimal diagnostic cut-off point for ELISA test.
Methods: We gathered 56 confirmed cases of brucellosis. Furthermore blood samples from 126 controls including 73 healthy controls and 53 without brucellosis febrile patients were collected. In all of the cases and controls ELISA Ig G and ELISA Ig M levels were measured and compared with each other by Box plot graph and the Receiver Operating Characteristic (ROC) curve. The sensitivity and specificity of ELISA Ig G and Ig M were fixed in different cut-off values and Ig G and Ig M levels yielding maximal sensitivity plus specificity were selected for determination of optimal cut-off point.
Results: The nineteen patients had positive blood cultures for Brucella melitensis. The standard agglutination test results were 1/160 or more in 54 patients. The Box plot graph indicated a high degree of dispersion for Ig G and Ig M data in patients with brucellosis compared with febrile patients without brucellosis and healthy controls. We observed partial overlap for Ig M data (not for Ig G) between cases and controls. The area under ROC curve for discrimination of cases and healthy controls was more for Ig G than Ig M.
Conclusions: The ELISA Ig G is more reliable test than ELISA Ig M in diagnosis of brucellosis. Using cut-off of 10 IU/ml and 50 IU/ml have the most sensitivity (92.9%) and specificity (100%) for ELISA Ig G test, respectively.
Jalal Rezaei, Khalil Esfandiari, Hassan Tavakoli , Mahmood Sadooghi , Mehrdad Hasibi , Mehrdad Behzadi ,
Volume 67, Issue 6 (9-2009)
Abstract
Background: Central venous catheter (CVC) related infections are important complications of cathter application. This study assessed the usefulness of mupirocin in prevention and control of these infections.
Methods: In this randomized clinical trial, consecutive surgical patients requiring central venous catheter (for more than 2 days) in Amir-Alam Hospital from 2006-2008 were enrolled. Patients were divided in two groups in “case group” patients received topical mupirocin 2% every 48 hours at the time of insertion of catheter and dressing change and for “control group” mupirocin was not used. All of the patients received chlorhexidine and enoxoparin as complementary treatments. Two groups were comparable in regard of age, sex and risk factors.
Results: One hundred eighteen patients enrolled in the study (57 in case and 61 in control group) completed the study. 84 catheters in case group and 88 catheters in control group were inserted. The catheters in 90% of patients were inserted in jugular vein. At the end of study 29(16.8%) patients (16 in control versus 13 in case group) had catheter colonization (p=NS). Catheter related bloodstream infection was observed in 16(9.3%) patients (6 in case versus 10 in control group) (p=NS).Catheter related local infection was seen in 2(1.1%) patients of control versus none of mupirocin group. (p=NS).
Conclusions: Mupirocin was not effective to control and prevention of bacterial colonization and catheter related infection.
Rasoulinejad M, Bouyer M, Emadi Kouchak H, Hasibi M, Mollazadeh N, Moradmand Badie B,
Volume 68, Issue 10 (5 2011)
Abstract
Background: Tuberculosis with high prevalence in HIV/AIDS
patients is the main reason for morbidity and mortality in these patients.
About one-third of patients with HIV infection
have concomitant tuberculosis. Lack of appropriate infection control on many
social and economic communities will impose. Comprehensive study on the effects
of anti-tuberculosis drugs in patients with HIV infecting
less done, also due to the importance of reducing morbidity and mortality,
reduce the cost of disease, identifying drug pharmacokinetics, the importance
of completing treatment tuberculosis, this study was performed to evaluate the
effects of anti- tuberculosis drugs on HIV infection
and to identify the drug pharmacokinetics and so more complete tuberculosis
treatment.
Methods: A historical cohort study was performed on
patients referring to the research center for HIV/AIDS,
consultation center, department of infection diseases of Imam
Khomeini Hospital
in Tehran, Iran. A
total number of 75 cases with HIV
negative versus HIV positive patients
with pulmonary tuberculosis and positive sputum smear in accordance with
inclusion and exclusion criteria were selected.
Results: In this study, the frequency of peripheral neuropathy 27(73%),
arthralgia 31(83.8%), vomiting 18(48.6%),
headache 26(70.3%), dizziness 20(54.1%),
renal toxicity 4(10.8%) and of skin rash 10(27%)
in patients with HIV virus infection were
significantly more than HIV- negative patients.
Hepatotoxicity, fever and anemia were not significantly more common in patients
who infected with HIV virus.
Conclusion: The HIV patients, who have not received antiretroviral
drugs during tuberculosis treatment, may show higher incidence of
anti-tuberculosis drugs complications.
Hasibi M, Jafari S, Khazraiyan H, Dehghan Manshadi Sa,
Volume 70, Issue 12 (5 2013)
Abstract
Background: Amphotericin B Deoxycholate (ABD) has been the best therapeutic agent for treatment of most systemic fungal infections. However, untoward adverse effects like nephrotoxicity may limit its appropriate therapeutic use. We studied administration of fat emulsion early after infusion of ABD to evaluate its effects on ABD-associated nephrotoxicity.
Methods: This study was a randomized clinical trial. Patients with fungal infections admitted in Amir-Alam and Imam-Khomeini University Hospitals, Tehran, Iran, entered the study during 1390- 1391. The patients were randomized to intervention and control groups. In both groups, patients received 1mg/kg/day ABD in dextrose 5%. In intervention arm, the patients additionally received intralipid 10% daily that was started as soon as possible within one hour after infusion of ABD. ABD-associated nephrotoxicity (a minimum 50% increase in baseline serum creatinine to a minimum of 2mg/dl), daily serum creatinine changes during first two weeks of treatment and some other relevant indices of renal function were compared between groups. ABD-related hypokalemia was also compared as an additional target.
Results: Thirty one patients entered the study. ABD-associated nephrotoxicity and values of other relevant indices of renal function were not different between intervention and control groups (P>0.05). Daily changes in serum creatinine level within first two weeks of treatment in both groups were not also statistically different (P=0.62). Furthermore, ABD-related hypokalemia was not significantly different between groups (P=0.47).
Conclusion: Administration of intralipid 10% early after infusion of ABD in dextrose 5% does not have any effect in decreasing ABD-associated nephrotoxicity. Moreover, it does not have any significant effect on ABD-related hypokalemia.
