Showing 7 results for Khazaei
Ghazi Saeidi K, Jafari Javid M, Khazaei Koohpahr M,
Volume 59, Issue 5 (9 2001)
Abstract
Postoperative nausea and vomiting is a common complication that all anesthesiologist are familiar with the problems of its consequences. Although continued research on the recognition of factors affecting the incidence of PONV is being done but they are not sufficient and the need for research along with advances in anesthesiology and newer drugs are considered. In this prospective cohort study 400 children of 3 to 12 age who has been operated for general surgery (other than eye, thorax and upper abdomen) and orthopedic surgery in the Imam Khomeini and Children Medical Center Hospital has been evaluated. Of these, 200 children who had smoking parent and according to definition were passive smokers and the other 200 children had no smoking parents. Both the groups were matched for sex, age, and type of operation. With the analysis of data we noted that the incidence of PONV in both groups was 19.5 and there was no significant difference between the two groups. (Passive smoker 19 percent and non-passive smoker 20 percent). We also noted a relation between the duration and the incidence of PONV. So operation with more than 2 hours had higher incidence of PONV. There was also positive relation between PONV and controlled ventilation. However, there was no significant difference as the sex and type of operation was concerned. In conclusion, children of smoker parents suffer more PONV than children of non-smoker parents if operation takes longer than two hours or the patient is mechanically ventilated during operation.
Marzieh Ghafarnegad , Neda Arjmand , Zahra Khazaeipour ,
Volume 67, Issue 10 (1-2010)
Abstract
Background: Polycystic ovary syndrome (PCOS) is a common cause of ovulation insufficiency and then infertility. Therapeutic options to induce ovulation in anovulatory PCOS patients are clomiphene citrate, metformin, tamoxifen, dopamine agonists (bromocriptin), Gonadotrophin and laparoscopic ovarian electrocautery (LOE). Gonadotrophin and LOE are important options in anovulatory clomiphene citrate-resistant patients with PCOS. Literature data regarding compare of the efficacy of these two treatments are few. Therefore we aimed to study the pregnancy rates of these treatments in infertile clomiphene citrate-resistant patients with PCOS. Methods: A randomized clinical trial study was carried out in infertile clomiphene citrate-resistant patients with PCOS, referred to infertility clinic of Mirza Koochackhan Hospital of Tehran University of Medical Science in Tehran, Iran, between 2003 and 2008. Results: A total of 100 patients women were randomly allocated in two groups. There were no differences in age and pimary and secondary infertility duration. In LOE treatment group, eight cases (16%) were pregnant and all delivered at term. in gonadotrophin treatment 14 cases (28%) were pregnant, 10 cases (20%) delivered at term but four cases aborted. The cost in gonadotrophin treatment was significantly more than laparoscopic ovarian diathermy (p<0.001). In logistic regression analysis, age, BMI, cost and kind of treatment had no significant effect on pregnancy rate. Conclusions: Pregnancy and abortion rate in gonadotrophin treatment was more than LOE but the difference was not significant. More studies are needed.
Foruhesh Tehrani Z, Khazaeian K, Malayeri A, Faghani R,
Volume 67, Issue 11 (4 2010)
Abstract
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Background: Breast cancer is
the most common cancer and the second most common cause of death from cancer in
women. HER2 is an epidermal growth factor receptor which plays a
substantial role in pathogenesis of breast cancer and also a target for new antineoplastic
drug Herceptin. This study was conducted for determining the correlation between HER2
overexpression and histopathologic characteristics of breast cancer and also
degree of intraobserver and interobserver agreement in scoring of Immnohistochemistry
(IHC) slides between pathologists in samples referred to
pathology ward.
Methods: This study was conducted as a
descriptive cross sectional study. Among the breast cancer samples referred to pathology ward in
Shariati Hospital in Tehran, Iran. 140 samples have been selected
sequentially using simple non-random sampling method. All the information has
been extracted using medical records and pathology reports.
Results: This study showed significant difference between
diagnosis and HER2 status (p<0.05). Significant difference observed between lymph node invasion and HER2 status (p<0.05). Positive significant association between the size and tumor grade
with HER2 status (r=0.188, p=0.026), Significant difference
between histopathologic
types with scoring of HER2 (p=0.001). Significant difference between histopathologic types with lymph node invasion (p=0.001).
Agreement level of HER-2 scoring was shown to be nearly perfect between two
observers (kappa statistic= 0.715) and the same observer (Kappa statistic= 0.78).
Conclusion: We do not recommend IHC and FISH test in invasive lobular carcinoma of breast and
uncommon subgroups of breast cancer except in invasive ductal carcinoma
and its subgroups.
Firoozeh Akbari Asbagh, Mahak Papan, Zahra Khazaeipour,
Volume 67, Issue 12 (6 2010)
Abstract
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Background: Insulin resistance is common in women with Polycystic
Ovary Syndrome
(PCOS) and can cause poor outcome of infertility
treatment. The aim of our study
was to assess the effect of treatment with metformin on outcome of Intra
Cytoplasmic Sperm
Injection (ICSI)
in infertile PCOS women.
Methods: A randomized clinical trial study was carried
out in infertile women with PCOS, before ICSI,
referred to infertility clinic of Mirza
Koochackhan Hospital
of Tehran University
of Medical Science
Tehran, Iran,
between 2006 and 2008.
The patients were randomized in two groups of
metformin 500 mg Po,
three times daily, six weeks before the ICSI
cycle and placebo patients in each group were divided into BMI
<28 kg/m2 and BMI
&ge28 kg/m2.
Results: Of 52
study women 26(50%) were in metformin
group. mean age were 29.8±4.9 year in
metformin group versus 29.4±5.9 year and
placebo groups. Treatment with
metformin, in subgroup of BMI <28 kg/m2,
significantly increased number of mature follicle (p=0.01),
embryo (p=0.04),
oocytes (p=0.007)
and mature oocytes (p=0.03)
but in subgroup of BMI&ge28 kg/m2,
there was no significant difference in the metformin and placebo groups (p>0.05).
Metformin treatment caused more chemical and
clinical pregnancy rates, and less abortion rate in overweight and normal patients,
but the differences were not significant (p>0.05).
Logestic regression analysis showed, adjusting
number of mature follicle, number of embryos, quality of embryos, oocytes and BMI
and treatment showed no significant effect on clinical pregnancy
rates (p>0.05).
Conclusions: Among normal weight PCOS
women, effect of treatment with metformin is better than overweight PCOS
women. However further
studies are needed.
Yarandi F, Shirali E, Eftekhar F, Khazaeipour Z,
Volume 68, Issue 9 (6 2010)
Abstract
Background: Surgery is the most effective treatment of well-differentiated endometrial cancer. But using systemic progestins, have been evaluated to treat the young patients with well-differentiated endometrial cancer who wish to preserve their fertility. The aim of this study was the evaluation of megestrol acetate on endometrial adenocarcino-ma with regard to the receptors.
Methods: This was a quasi-experimental study. In 16 infertile patients with stage Ia well-differentiated endometrial adenocarcinoma. The treatment initiated with 160mg/d of megestrol acetate and continued with 320mg/d for non-responsive cases. All of the patients followed with FD&C and hysteroscopy. The responsive patients were referred to IVF group and they were followed for three years.
Results: Of nine patient in the first step of the study, 4 (25%) became pregnant. Eight patients underwent Total Abdominal Hysterectomy (TAH), and one was retreated conservatively. Of seven patient of second step of the study, five are under treatment at the time of closing the paper (three cases candidate for IVF and two are under 320 mg/d megestrol acetate), one patient is a candidate for hysterectomy, and one exited of study because of male infertility. All of the patients were progesterone receptor positive, and only one was estrogen receptor negative.
Conclusion: Conservative treatment of early stage well-differentiated endometrial adenocarcinoma with progestins may be used in highly selected young patients who have not completed their family. Close long- term follow up in this special group of patients is necessary. The evaluation of estrogen and progesterone receptors assay may be useful in predicting response to the treatment.
Shadi Khazaei, Shahrbanoo Keyhanian , Mahila Monajati , Shahram Ala, Ebrahim Salehifar ,
Volume 75, Issue 9 (December 2017)
Abstract
Background: Methotrexate (MTX) is commonly used in the hematology-oncology units and is frequently associated with adverse effects. High-dose methotrexate (HDMTX) is indicated in the treatment of acute lymphoblastic leukemia (ALL), osteosarcoma, systemic non-Hodgkin lymphoma and primary central nervous system (CNS) lymphoma. The side effect profile of MTX varies markedly according to dose. The aim of this study was to evaluate the uses and adverse effects of HDMTX in a cancer center in north of Iran.
Methods: This cross-sectional descriptive study carried out in Emam Sajjad Hospital, Ramsar, Iran from June 2016 to July 2017. Doses more than 500 mg/m2 of MTX was considered as a high-dose. Hydration status, evaluation of the renal and hepatic function, blood tests, urine pH, doses and frequencies of leucovorin administration, measurement of serum levels of MTX and side effects were evaluated. Recommendations of UpToDate 2017 were considered as standards of administration of HDMTX.
Results: Forty-four courses of HDMTX were evaluated in this study. HDMTX were prescribed for lymphoma (30 cases), ALL (8 cases) and osteosarcoma (6 cases). In all patients, hydration was done with 1340.9±894 normal saline plus 25 ml sodium bicarbonate 8.4%, one to two hours before HDMTX. The solution used for dilution of MTX was 5% dextrose (1022.7±105.5 ml). Urine pH was not measured in any patient. The frequency of leucovorin administration was 5.64±3.03 times with doses of 17.6±1.7 mg/m2 every 6 hours. Serum levels of MTX were not measured in any patient. Blood urea nitrogen and creatinine measurement was carried out before administration of HDMTX in all patients. The most common adverse effects were nausea (64.4%), anxiety (44%) and headache (43.2%).
Conclusion: The appropriate aspects of HDMTX usage were good hydration, urine alkalinization with bicarbonate and administration of leucovorin in patients receiving HDMTX, whereas monitoring of serum levels of MTX and administration of bicarbonate based on urinary pH were not done in any of the patients.
Daryoush Afshari, Mansour Rezaei, Mojtaba Khazaei, Negin Fakhri ,
Volume 81, Issue 12 (March 2024)
Abstract
Background: One of the first-line treatments to prevent migraine attacks is Sodium Valproate. "Booali Daroo" pharmaceutical company has made a herbal capsule called Sodae based on traditional Iranian medicine. The aim of this study is to compare the effect of Sodae and Sodium Valproate on migraine headaches.
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Methods: This two-center, double-blind, randomized clinical trial was conducted between December 2021 and July 2022 in the cities of Kermanshah and Hamadan. In this study, 76 migraine patients were randomly divided into two groups. One group received routine medication with Soda capsules and the other group received routine medication with Valproate capsules. Tow group were examined and followed up for three months. Data related to demographic and clinical information of patients were collected and entered into SPSS software version 25. Data analysis was done with a significance level of 0.05.
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Results: Overall, 76 patients assessed (36 in the Sodae group and 40 in the Valproate group). The reduction of headache indicators was not significant between the two groups; in such a way that: the frequency (7.49±6.1 vs. 5.75±4.5, P=0.183), the severity (5.66±1.6 vs. 6.34±1.8, P=0.089), the duration of attacks (23.48±30.5 vs. 32.35±32.6, P=0.069), and the Migraine Disability Assessment Score (53.94±77.3 vs. 95.94±104.2, P=0.061) respectively in Valproate and Sodae. Examining different classes of MIDAS score showed that at the end of the study compared to the beginning of the study, the number of people with severe disability decreased significantly and their disability changed from severe disability to lower degrees of disability (P<0.05). The frequency of side effects was not significantly different between the two groups (12 patients (35%) in Sodae versus 21 patients (55%) in Valproate, P=0.090).
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Conclusion: In terms of frequency, intensity and duration of migraine headaches as well as side effects, there was no significant difference between Sodium Valproate and Sodae groups.
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