Showing 62 results for Miri
Sh Niro Manesh , A Amiri , Sh Ali Yari ,
Volume 52, Issue 3 (30 1994)
Abstract
In this study, 1600 pregnant women who had referred to two prenatal clinics (Imam Khomeini and Mirza Kochek-Khan) were investigated. Ninety cases of asymptomatic bacteriuria were observed 77 of those cooperated with us until the end of our study. The subjects, who were within the 14-36 weeks of gestational age, were randomly divided into two groups: Group A received the medicine (Amoxicillin) in a single-dose (3gr.) and, group B received it within seven days (1gr. TDS). The rate of recovery (65% in group A and 56.8% in group B), based on chi-squared test, showed no significant difference (P=0.747%). According to the results of this study, we can conclude that single-dose treatment has the same value as a seven-day treatment and the advantages such as decreased total dose, lower cost, and a better patient compliance.
H Alaiy , R Hajiamiri ,
Volume 55, Issue 5 (1 1997)
Abstract
We studied the effect of the selective alha-2 adrenoceptor blocker idazoxan and precursor serotonin (5-HTP) on anxiety-related behavior in rats. The conflict drinking test, and evaluator plus-maze were used as model. Idazoxan (2 mg/kg) showed an anticonflict effect, having doses dependently increased the number of punished lickes. 5-HTP showed that anxiolytic-like effect in both models. This drug reversed action and produced anxiogenic-like effect at high doses. In contrast, arecholine which is a cholinergic muscarinic agonist drug, produced anxiogenic-like behavior. At 2 mg/kg increased number of entrance (OE) and using time (OT) in open arms in montgomery's test. Anxiolytic-like effect of this drug was less than of chlordizepoxide. These results showed that increase release of noradrenaline in synaptic nerve terminals of neurons produced anxiety-related behavior. While high release of serotonin in this area reduced behaviors disorder in rats.
Miri S R, Kiani A, Mehrabi V,
Volume 61, Issue 6 (15 2003)
Abstract
Ectomesenchimal cells, placed near the embryonal tube, migrate to down and share in facial and cardiac structures. Migration or differentiation disorders of these cell causes cleft lip/ or palate and congenital heart disease (CHD). This item was performed to determine co-appearing of cleft and CHD and to know adjutant factors to that for better management of these patient.
Materials and Methods: Two hundered children with cleft lip and palate were registered. Finding was analyzed by fisher's exact text and chi-square tests.
Results: CHD is ten times of normal population in this research (p< 0.01 and odd ratio 10.39) and incidence of CHD in cleft is high in cleft patient if another congenital animalies were presented (p< 0.001, odd ratio 5.18).
Conclusion: By attention to higher incidence of CHD in cleft patients, it is advised to cardiologist consulting before cleft surgery for better managing.
Miri S M, Heidarzadeh C, Fakhr Tabatabai S A, Ghanaati H,
Volume 62, Issue 4 (11 2004)
Abstract
Background: This investigation was conducted in order to study angiographic findings in patients with cerebral aneurysm.
Materials and Methods: The study conducted on 136 cases of ruptured cerebral aneurysms between 1995-2000 confirmed by means of 4-vessel cerebral angiography to get an insight to racial, geographic and environmental factors predisposing to the occurrence of subarachnoid hemorrhage and aneurysm formation. Results: The data analysis revealed the following
Results: 58% of the population comprised of male and 42% female with a mean age of 46 years. 89% of the aneurysms were found in the anterior circulation and 11% occurred in the posterior cerebral circulation. The most common site in both the sexes was the anterior communicating artery. 9.6% of the patients displayed two separate aneurysms. 5.2% of the aneurysms were found to be giant aneurysms and 3% of the patients had fusiform aneurysms.
Conclusion: The low average age, a predilection in male population and the prevalence of aneurysms at carotid and middle cerebral artery bifurcation and the distal branches of anterior cerebral artery and a higher incidence of anterior communicating artery in women were the findings observed in this study.
Shayegan M, Poor Fathollah A.a, Namiri M, Babaei Gh,
Volume 63, Issue 4 (13 2005)
Abstract
Background: Tumor necrosis factor alpha (TNF-) is a major mediator of inflammatory responses and also plays a role in Febrile non-hemolytic reactions (FNHRs) after platelet concentrates (PCs) injection. It is thought contaminating WBCs are the source of these cytokine so inactivating or decreasing of these WBCs will be effective to decline of the cytokines. Due to difference results between different methods for TNF measurement, in this study we compared Immunoassay and Bioassay methods to determine TNF- in supernatants of PCs.
Materials and Methods: TNF- was measured by ELISA (Immunoassay) and by the L929 cytotoxicity Bioassay in supernatant of random donor PCs (RD-PC) prepared by platelet rich plasma (PRP). These platelet concentrates were divided in 4 groups: 1- unfiltered , non-irradiated RD-PCs (N=13) 2- unfiltered and -irradiated RD-PCs (N=16) 3- filtered , non-irradiated RD-PCs (N=14) 4- filtered and -irradiated RD-PCs (N=11)
Results: Our results showed: • TNF- was increased (by ELISA) in unfiltered non-irradiated units during storage but not in -irradiated and filtered RD-PCs in day 3. Compared to unfiltered PCs in filtered units, pre-storage filtration and irradiation prevented a rise in the TNF- in day 3 of storage. • There was no correlation between ELISA and the cytotoxicity L929 bioassay .
Conclusion: It has been previously reported that different quantitative results can be obtained when TNF alpha is measured in biological fluids by Bioassay and Immunoassay. This is thought to be related to the presence of antigenic forms of TNF alpha that cannot be detected by bioassay, such as complexes with soluble receptors (sTNF-R) or TNF alpha monomers.
M Amiridavan, S.m Sonbolestan, S.a Kholvvat, Sh Nemati ,
Volume 64, Issue 1 (30 2006)
Abstract
Background and Aim: Sudden Sensorineural Hearing Loss (SSNHL) is an emergency situation, and is one of the most controversial subjects in domain of otolaryngology. In this article, we have analyzed some Epidemiologic Characteristics, clinical features, audiological Characteristics, and other findings in routine serological tests and MRI of 48 cases with SSNHL ,who came or were referred to us in the past 2 years. Study design: Cross sectional.
Materials and Methods: In 48 patients with chief complaint of SSNHL, from June 2003 to Feb. 2005, who were admitted in clinic of otolaryngology- in Kashani Hospital -Isfahan- Iran, physical examination and history taking, audiological evaluation, MRI,and serological tests were performed in a similar way , and data were analyzed by SPSS software.
Results: From 48 cases(M:28 ,F:20) with mean age of 40.9(+/-15.9) years, left ear was involved in 26 cases (54.1%) ,and right ear in 19 cases (39.5%) ,and in 3 cases (6.3%),both sides were involved. The severity of hearing loss was “subjectively” HIGH in 78% of patients, and the mean threshold of hearing had been calculated as 69 dB. The most common pattern in pure tone audiometry curves ,was ‘flat pattern’(75%) ,and then ,’down sloping pattern’(16%).The most adjunctive clinical symptom was “tinnitus”(in 78.7%), and 40% of patients had “true vertigo”. 44.4% of our patients had some evidences of upper respiratory tract infections (URIs) during recent 2 weeks. Positive family history, smoking, alcohol intake ,oral contraceptive and ototoxic drugs consumption were uncommon. 24% of cases (11 of 39) had increased ESR, and 100% of 39 patients had negative VDRL. Diabetes mellitus was the most common underlying disease (in 6 cases).From 20 patients ,who were succeeded to perform brain and ear MRI, 2 cases had tumor in internal auditory canal and cerebellopontine angle.
Conclusion: SSNHL has some limitations in being studied histopathologically or in the form of clinical trials, and in nearly all of its aspects there are some mysteries to be cleared. Our ‘Iranian’ patients demonstrated some special characteristics.
Nemati Sh, Amiridavan M, Jamshidi M, Saberi A, Majlesi A,
Volume 65, Issue 4 (3 2007)
Abstract
Background: Sudden sensorinueural hearing loss (SSNHL) is a baffling condition for patients, and its etiology, audiologic characteristics, prognostic factors, and treatment are still controversial.
Methods: In this prospective study, we performed pure tone audiometry (PTA), impedance acoustics (IA), auditory brainstem responses (ABR), otoacoustic emissions (OAE), and transiently evoked otoacoustic emissions (TEOAE) before beginning treatment for 53 patients with SSNHL. We then entered each patient, randomly and alternately, in one of two treatment groups: oral steroids + acyclovir vs. intravenous urographin.
Results: In 22 (41.5%) of the 53 patients (22 female, 31 male), we found negative or no signal to noise ratio and overall correlation in TEOAE. Furthermore, 26 cases (49%) had positive overall correlations less than 50%, and five cases (4.4%) had overall correlations >50%. Although 15 cases (28.3%) responded well, 20 cases (37.7%) showed only a partial response, and 18 cases (33.9%) had poor or no response to our treatment. The mean value for overall correlation in the three subgroups of patients (no response, partial response, and complete response) was -3.5% (±1/16%), + 11% (±1.99%), and +36.6% (±3.07%) respectively (P = 0.01). From 52 cases, 20 had no reproducible wave in ABR (38.5%), three cases had abnormal ABR with normal OAE, all of which responded completely to treatments. Thirteen cases had abnormal ABR and OAE, none of which responded to treatment, and six cases had normal ABR with abnormal OAE, which often responded to treatment.
Conclusions: ABR and OAE may be useful in the diagnosis of SSNHL and determining the site of such lesions as ischemia or neuropathy. The overall correlation (and S/N ratio) in TEOAE is a valuable prognostic factor in SSNHL.
Amiri H R, Makarem J,
Volume 66, Issue 2 (1 2008)
Abstract
Background: Total spinal anesthesia is a complication of lumbar epidural anesthesia following undiagnosed subarachnoid or subdural injection of local anesthetic. Although many achondroplastic dwarfs have a normal spine, catheter insertion may be more problematic with a narrow epidural space making a subarachnoid tap more probable. Other malformations associated with achondroplasia, such as prolapsed intervertebral discs, reduced interpedicular distance, shortened pedicles, and osteophyte formation, combined with a narrow epidural space may make identification of the space difficult and increases the risk of dural puncture. Furthermore, subarachnoid tap or dural puncture may be hard to recognize if a free flow of CSF is difficult to achieve due spinal stenosis. Yet, for those who meet the criteria, epidural regional anesthesia is frequently preferred over other forms, which often have more or more dangerous side effects in this type of patient.
Case report: A 22-year-old achondroplastic male dwarf patient was scheduled for pelvic mass resection and was considered a candidate for continuous epidural anesthesia. The anesthesia became complicated by total spinal anesthesia, which was reversed following supportive management for about two hours.
Conclusion: There is significant debate over the composition and volume of the test dose, especially for patients with achondroplasia. We nevertheless recommend repeated test-doses during the accomplishment of epidural anesthesia to exclude unintended intravascular, intrathecal or subdural injection, keeping in mind that a test dose of local anesthetic does not completely prevent complications.
H.r Amiri, J Makarem, S Beiranvand,
Volume 66, Issue 5 (5 2008)
Abstract
Background: post operative pain is an essential problem. Epidural infusion of two different doses of bupivacaine in pain management of post orthopedic surgeries was studied.
Methods: In this double blinded randomized clinical trial we studied two groups of 42 patients undergone knee surgery. Based on block randomization, patients received two different concentration of bupivacaine (0.1% or 0.125%) in combination with fentanyl (1.7µg/ml). The beginning infusion rate was 5ml/h. Pain scores were documented by a blinded researcher 6, 12, 18, 24 and 48 hours after completion of surgery according to VAS tool. Patient satisfaction, complications and treatment failure (when increased volume of epidural infusion or other analgesics were required) were evaluated.
Results: In higher bupivacaine dose group, post operative pain scores were not significantly lower in different hours and during the follow up (both p values less than 0.001). After 48 hours, patients satisfaction were more in the higher bupivacaine group. There were no significant differences in complications. Treatment failure was more significant in lower bupivacaine dose (33.3% versus 11.9%, p=0.03).
Conclusion: continuous epidural infusion of both bupivacaine and fentanyl provide acceptable post operative pain control in orthopedic patients. Although higher concentrations of bupivacaine during first hours are more effective, lower concentrations are as effective as the higher one, during subsequent hours.
Amiri Hr, Makarem J,
Volume 67, Issue 2 (5 2009)
Abstract
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Background: Successful
brachial plexus blocks rely on proper techniques of nerve localization, needle
placement, and local anesthetic injection. Standard approaches used today (elicitation
of paresthesia or nerve-stimulated muscle contraction), unfortunately, are all
"blind" techniques resulting in procedure-related pain and
complications. Ultrasound guidance for brachial plexus blocks can potentially
improve success and complication rates. This study presents the
ultrasound-guided brachial plexus blocks for the first time in Iran in adults
and pediatrics.
Methods: In this
study ultrasound-guided brachial plexus blocks in 30 patients (25 adults &
5 pediatrics) scheduled for an elective upper extremity surgery, are
introduced. Ultrasound imaging was used to identify the brachial plexus before
the block, guide the block needle to reach target nerves, and visualize the
pattern of local anesthetic spread. Needle position was further confirmed by
nerve stimulation before injection. Besides basic variables, block approach,
block time, postoperative analgesia duration (VAS<3 was considered as target
pain control) opioid consumption during surgery, patient satisfaction and block
related complications were reported.
Results: Mean
adult age was 35.5±15 and in pediatric group was 5.2±4. Frequency
of interscalene, supraclavicular, axillary approaches to brachial plexus in
adults was 5, 7, 13 respectively. In pediatrics, only supraclavicular approach
was accomplished. Mean postoperative analgesia time in adults was 8.5±4
and in pediatrics was 10.8±2. No block related complication were observed
and no supplementary, were needed.
Conclusions: Real-time
ultrasound imaging during brachial plexus blocks can facilitate nerve
localization and needle placement and examine the pattern and extend of local
anesthetic spread.
Amiri Hr, Makarem J, Noyan Ashraf Ma,
Volume 67, Issue 3 (5 2009)
Abstract
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Background: Bispectral index (BIS
index) shows the depth of anesthesia. The effects of drugs on BIS and amnesia are different. This study was performed to evaluate the
association between two different sedative regimens on BIS
and amnesia.
Methods: In this clinical trial, 60 patients who needed elective orthopedic surgery under regional
anesthesia with intravenous sedation were elected. Patients divided in two
equal groups based on sedation protocol by block randomization method:
midazolam plus fentanyl group (MF group) or propofol group (P group). Dose of sedative drugs were adjusted according to clinical
findings of sedation. Depth of sedation in all patients, preserved in four
based on modified Ramsey Sedation Score. Patients questioned about spontaneous
recall after full awakening in recovery room. Recall of any event during
operation considered as failed amnesia. Correlation of BIS
index with recall was measured in two different groups separately.
Results: The frequency of recall was 2 (6.7%) in P
group and 10 (33.3%) in MF
group (p=0.01). The mean± SD
of BIS in P group was 76±5 (68-91) and in MF group was 93.4±5 (77-98) (p<0.001). The difference of BIS in patients without amnesia (p=0.019)
and with amnesia (p<0.001) in two groups were significant, respectively. No
delay in recovery was observed.
Conclusion: Although the Modified Ramsey Sedation Score and
clinical sedation indices were the same, but BIS in
patients varied in a wide range. Hypnotic drug was a main determinant of BIS
score and amnesia.
Eshraghi S, Salehipour Z, Pourmand Mr, Rahimi Forushani A, Zahraei Salehi Mt, Agha Amiri S, Bakhtyari R, Abedi Mohtasab Tp, Mardani N, Seyed Amiri S, Soltan Dallal Mm,
Volume 67, Issue 7 (7 2009)
Abstract
Background: Staphylococcus aureus is a major foodborne pathogen throughout the world. Enterotoxins and toxic shock syndrome toxin-1 are important virulence factors and as pyrogenic toxin superantigens have profound effects on the ir host. Thus circulation of TSST1 producing S.aureus among people and food chain is a worrying issue. The present paper was conducted to study Prevalence of tst, entC, entA and entA/C genes in staphylococcus aureus strains isolated from different foods.
Methods: Over 1040 food samples have been analyzed differentially according to Iran national standard (number= 1194) for S.aureus identification. After DNA extraction, PCR reactions were carried out by reference strain as positive control, adequate primers.
Results: At present study, prevalence of foodstuffs contaminated by S.aureus isolates was about 9.5% (100 strains). Of 25% of isolates producing entC, 28% (seven strains) had tst gene at the same time and of 8% of isolates producing entA, 12.5% (one strain) were positive for tst genes simultaneously. Altogether of 9% isolates producing combination of entC and entA, 44.4% (four strains) were also producer of tst gene.
Conclusion: Prevalence of TSST1 producing strains in combination with enterotoxin genes is considerable especially with entC and A plus C. On the other hand, circulation of these isolates in humans, animals, foods and environment has hazardous effect for general public health.
Mahmoudi Rad M, Zafarghandi As, Amel Zabihi M, Mirdamadi Y, Rahbarian N, Abbasabadi B, Shivaei M, Amiri Z,
Volume 67, Issue 9 (6 2009)
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Background: Vulvovaginal
candidiasis is a fungal disease with itching, and vaginal thick white
discharge. Most of
non-albicans species have less sensitivity to azoles. So, definition of candida species which lead to vulvovaginal candidiasis is very important to perfect
usage of drugs. In the present study 191 Candida isolates from 175 patients who admitted in Gynecology department of
Mahdieh Hospital during the period 1385-1387 were identified by multiplex PCR.
Methods: One hundred seventy five vaginal swab specimens from
patients were cultured on Sabouraud
Dextrose Agar (SDA). The internal transcribed spacer 1 (ITS1) region between the 18S and 5.8S rRNA genes and a
specific DNA fragment
within the ITS2 region of Candida albicans were amplified and the multiplex PCR products were separated by electrophoresis in 2% agarose gel (200 mA, 140V), visualized
by staining with ethidium bromide, and photographed.
Results: One hundred ninety one Candida isolates were identified in vaginal swab specimens
from 175 patients. In 89.7% of cases, single candida species and in 10.3% cases,
multiple candida species were isolated. C.
albicans (65.1%), C.
glabrata (13.1%), C.
tropicalis (6.2%), C. krusei (4%), C. guilliermondii (0.6%), C. parapsilosis (0.6%),
C. glabrata and C. albicans (5.7%), C. albicans and C. parapsilosis (1.1%),
C. glabrata and C. tropicalis (0.6%),
C. krusei and C.
tropicalis (0.6%), C.
albicans and C.
tropicalis (0.6%), C. krusei and C. albicans (0.6%), C. glabrata and C. krusei (0.6%), and C.
glabrata and C. krusei and
C. albicans (0.6%) were the
cause of disease.
Conclusion: Our findings suggest that, the common cause of both
recurrent and non-recurrent vulvovaginal candidiasis was C. albicans, and then C. glabrata.
Also the most common mixtures of Candida species were combination of them
Soltan Dallal Mm, Yazdi Mh, Hassan Zm, Holakuyee M, Abedi Mohtasab Tp, Aminharaty F, Agha Amiri S, Mahdavi M,
Volume 67, Issue 11 (4 2010)
Abstract
Background: In according to immunomodulatory effect of probiotics and effect of these bacteria on the effectiveness of immune responses, at the present work we proposed the evaluation of oral administration of L.acidophilus on the immune statues in BALB/c mice bearing breast cancer.
Methods: A total of 30 In-bred BALB/c mices aged from six to eight weeks weighting 25-30g were randomly enrolled in our study, in two groups each consist of 15 mices. The L.acidophilus ATCC4356 strain used in this study was inoculated in MRS broth and cultivated for a day at 37°C under anaerobic conditions, collected by centrifugation and resuspend in Phosphate Buffer Saline (PBS). After preparation of proper amount of these suspensions it was orally administered to the mice with a gastric feeding, Control mices received an equal volume of PBS in duration of study.
Results: Results showed the increase in production of IFnγ (p<0.005), and decrease in production of Th2 cytokines such as IL4 (p=0.347) in the L.acidophilus administered mice in comparison to control group of mice. In addition the proliferation of immune cells in probiotic group was significantly higher than controls, and most importantly probiotic administered mice showed an increase in survival rate of this group compared to control mice (p<0.001).
Conclusion: Results of our study suggested that daily consumption of Lactobacillus acidophilus can regulate immune responses skewed Th1 balance that is needed against tumor, further studies is needed to investigate the other mechanisms of this effect.
Mahmoudi Rad M, Zafarghandi As, Shivaei M, Mahmoudi Rad N, Abbasabadi B, Amel Zabihi M, Amiri Z,
Volume 67, Issue 11 (4 2010)
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Background: Vulvovaginal
candidiasis is a common mucosal infection among immunocompetent, healthy women,
and is caused by opportunistic yeasts that belong to genus Candida. In this study, we isolated and identified the Candida species in the vagina of patients who admitted in
Gynecology Department of Mahdieh Hospital in Tehran, Iran to evaluate the in
vitro activities of fluconazole, miconazole, itraconazole and flucytosine against 191 clinical Candida isolates by the NCCLS microdilution method.
Methods: 191 Candida were isolated from vaginal secretions and identified
with conventional mycological methods in the diagnosis
of Candida species. The identity of all strains was confirmed genotypically by multiplex PCR. In vitro
susceptibility testing of vaginal Candida isolates was
performed by the NCCLS broth microdilution
method. The results were read at 48 h.
Results: Most C. albicans isolates (>90%) were sensitive in vitro to the antifungal agents
tested. Most C. glabrata isolates showed sensitivity to miconazole and then flucytosine while they were
more resistant to Itraconazole and fluconazole. Many isolates of C.
tropicalis were susceptible to
miconazole and then fluconazole. They
showed a little resistance to all antifungals tested and flucytosine-resistance
was the most frequent in the C. tropicalis isolates. High susceptibility to miconazole was observed in isolates of C. krusei and their susceptibility to the rest of the
antifungals tested was dose-dependent. fluconazole -resistance was
the most frequent in the C. krusei isolates.
Conclusion: Most isolates tested were susceptible to miconazole. A
trend toward increased resistance among C. glabrata and C.
krusei strains to antifungals tested was noted. Our
findings suggest that, miconazole should be the agent of choice for the treatment of resistant
vaginal candidiasis.
Bitara Ma, Azar M, Miri Sm, Sheikhrezai A, Alikhani M, Allahverdi M, Sharif Tabrizi A, Tayebi Meybodi A,
Volume 68, Issue 3 (5 2010)
Abstract
Background: Meningiomas are among the most common tumors of the brain. Skull base meningiomas comprise s major part of brain meningiomas. They are difficult to treat because of proximity to major vital neuro-vascular structures which makes their surgical resection hazardous and fraught with a high rate of complications. Radiosurgery is considered as an alternative efficient way to treat them, which targets the tumor and its supplying vasculature. The standard treatment consists of tumor eradication and its supplying vessels through homogeneous dose of 201 rays of cobalt
60 source.
Methods: In a case-series study, we report 230 meningiomas referred to Iraninan Gamma Knife Center, treated by radiosurgery with type C Gamma Knife. Radio-surgery was performed at a mean dose of 15 Gy and 50% isodose.
Results: Two hundred and thirty of all meningioma cases refered to our institute were skull base lesions. Eighty (35%) were new case and the rest were previously treated microsurgically one or more times. None of the patients died after treatment and the most common post-operative complications were headache (30 patients) and peri- tumoral edema (12 patients).
Conclusion: Tumoral control is defined as reduced tumor volume or as no change in tumor volume. Tumor control was achieved in 218 (95%) patients. In those who were not treated microsurgically, clinical improvement was more pronounced. Thus when suitable (favorable tumor size and absence of progressive mass effect signs) the patients could be primarily treated with Gamma knife. Other patients could be managed complementarily with radiosurgery after they are treated surgically.
Omolbanin Paknezhad, Khatereh Amiri , Marzieh Pazooki ,
Volume 68, Issue 8 (November 2010)
Abstract
Background: Because bronchial hyper responsiveness (BHR) has been shown to be a risk factor for asthma and lung function decline, interest has focused on diagnosing BHR. The aim of our study was to measure the association between airway caliber relative to lung size expressed as the ratio between forced expiratory flow, mid expiratory phase, divided by forced vital capacity (FEF25-75/FVC) and BHR measured by methacholine challenge test (MCT) to obtain a cutoff for this ratio and positive MCT.
Methods: We carried out a cross- sectional study on general Iranian population in 376 subjects aged 7-73 years who were referred to Shariati hospital in Tehran, Iran in an outpatient setting. There were 190 male (50.5%) and 186 female (49.5%) subjects. They had chronic respiratory symptoms such as cough and dyspnea. The physical examination was normal. Baseline spirometry was normal or equivocal. MCT was done for all subjects over a two year period (2009- 2010). Positive MCT was defined by PC 20≤4mg/ml.
Results: The methacholine challenge test was positive in 191 (50.8%) and negative in 185 (49.2%) patients. The mean of FEF25-75/FVC in positive MCT was 0.86±0.27 Vs. 0.91±0.28 in the negative ones (p=0.070). The sensitivity and specificity of FEF25-75/FVC for prediction of MCT results were 57.1% and 60.2% based on cutoff point of 0.85 in all patients, and 87.5% and 70.7% based on cut off point of 1 in allergic patients, respectively.
Conclusion: The FEF25-75/FVC appears to be a useful predictive ratio in allergic patients but not in general population.
Saberi H, Miri Sm, Poordel Namdar M,
Volume 68, Issue 9 (6 2010)
Abstract
Background: Topically applied tranexamic acid has been shown to decrease the
amount of blood loss associated with major spinal surgical procedures. The aim of this study was to evaluate the effects of locally applied tranexamic acid in epidural space on post-laminectomy blood loss.
Methods: One hundred patients who were scheduled to undergo laminectomy in Imam Khomeini Hospital in Tehran, Iran were enrolled in a clinical trial. Patients were divided into two groups of unilateral one level (n=50) and bilateral two level (n=50) laminectomy according to the extent of surgery. Each group was randomly allocated into two groups of tranexamic acid (n=25) and control (n=25). At the end of the operation, 250mg tranexamic acid, with volume of 5ml or 5ml of normal saline were poured on the site of surgery. The blood volume drained during first and second 24hr, and overall hemorrhage, plus the duration of post operative hospitalization were compared between the two groups.
Results: The bleeding volume in the 1st 24hr was significantly less in tranexamic acid than control group (p=0.001). The bleeding volume in the 2nd 24hr was significantly less in tranexamic acid than control group (p=0.001). The hospital stay was less in tranexamic acid compared to control group (2.16±0.37 Vs. 2.96±0.89 days, p=0.001) respectively.
Conclusion: Locally applied tranexamic acid in epidural space significantly reduces the amount of the 1st day, 2nd day and overall post-laminectomy blood loss, and duration of hospital stay.
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Vs. 2.96±0.89 days, p=0.001) respectively.
Conclusion: Locally applied tranexamic acid in epidural space
significantly reduces the amount of the 1st day, 2nd day and overall post-laminectomy blood loss, and
duration of hospital stay.
Ghanbari Z, Esmaeili M, Eftekhar T, Esmaeili M, Miri E,
Volume 69, Issue 5 (6 2011)
Abstract
Background: Overactive bladder (OAB) is one of the most prevalent diseases of lower urinary system. OAB disease is defined by the Standardization Subcommittee of the International Continence Society as urinary urgency, with or without urge incontinence, usually with frequency and nocturia with no proven infection or other obvious pathology. Treatment with the antimuscarinic agents tolterodine and oxybutynin is the mainstay of therapy for overactive bladder. The study was undertaken to compare the efficacy and side-effects of tolterodine and oxybutynin in a number of Iranian women.
Methods: This study consisted of two trials and done in Imam Khomeini Hospital in 2009 in one trial, 50 patients with overactive bladder were randomized to 4 weeks of treatment with 2 mg of twice-daily tolterodine, and in the other to 5 mg of three times a day oxybutynin. Urodynamic investigations, Episodes of urge urinary incontinence and adverse events were also evaluated.
Results: The results showed a good association between the questionnaire and cystometry data but urodynamic studies showed significant differences in efficacy. Tow groups showed significant improvements in all Symptoms, but The results showed that the two drugs had no significant differences in efficacy.
Conclusion: The data obtained by questionnaire indicated that both drugs increased quality of life but there were no significant differences between the two in symptom cure. Dry mouth was the most common side-effect in the two groups but unlike other studies it was higher in the tolterodine group. Therefore, our study did not show any preference between oxybutynin and tolterodine.
Bokharaei-Salim F, Keyvani H, Zamani F, Jahanbakhsh Sefidi F, Amiri A,
Volume 69, Issue 10 (5 2012)
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Background: Hepatitis
C
virus (HCV) is
essentially considered as hepatotropic, but virus sequences have also been
found in other important extrahepatic sites, including peripheral blood
mononuclear cells (PBMCs). This study was done to investigate the presence of mixed
infection and the differences between hepatitis C virus genotypes in plasma, peripheral blood mononuclear cells, and
liver biopsy specimens in patients with hepatitis C virus infection.
Methods : One hundred and fifty two patients with established chronic
hepatitis C infection attending Firouzgar Hospital, affiliated to Tehran
University of Medical Sciences, from September 2008
to April 2010 were enrolled in the present study. After collecting plasma,
peripheral blood mononuclear cell, and liver biopsy specimens, RNA was extracted from the samples
and hepatitis C virus genotyping was performed using INNO-LiPATM HCV II kit. The hepatitis C virus genotyping was confirmed by sequencing the RT-nested PCR product of 5'-UTR fragments.
Results : The mean age of the participants was 31.2±16.9
years. Multiple hepatitis C virus genotypes were detected
in 4 (2.6%) out
of 152 plasma
samples, 10 (6.6%) out of 152 peripheral blood mononuclear cell samples, and 9 (18.8%) out of 48 liver biopsy specimens. Hepatitis
C
virus genotypes were different in the plasma, PBMC, and liver biopsy specimens of 21
(13.8%) patients.
Conclusion: The present study
shows that a significant proportion of patients with chronic hepatitis C infection are infected by
multiple hepatitis C virus genotypes which may not be detectable in their plasma specimens.
