Showing 12 results for Moradmand
S Moradmand ,
Volume 55, Issue 6 (1 1997)
Abstract
This is a retrospective study on the records of patients with infarction admitted to C.C.U wards of Imam Khomeini hospital, Amir-alam hospital & Shariati hospital, during 7 months (1995-94). In total patients of 209 with average age of 59.5 years, there were 133 men with average age of 57.1 and 76 women with average age of 63.7 years. In this study, women with MI are older than men. From 209 patients with infarction, 51 patients had diabetes, that show diabetes prevalence of 24.4%. On the other side, there were 28 men & 23 women with diabetes, which indicates a prevalence of 21.8% among men and 30.2% among women. Thus diabetic women experience infarction more than diabetic men. This result is compatible with classic reports. The average age of diabetic patients is lower than non diabetics. This difference is between diabetic and non diabetic women (58.4 vs 66.1), but there's no difference between diabetic and non diabetic men (58.7 vs 57.7). Prevalence of diabetes in sixth & seventh decades has a peak among patients with infarction, and this is compatible with international reports that indicate CAD as prominent disease of diabetic patients in sixth and seventh decades. In our study hypertension and hyperlipidemia are the most frequent risk factors together with diabetes in infarction. The duration of disease before infarction was from 5 to 15 years. Concerning treatment of diabetic patients we showed that, as most patients in these ages are non insulin-dependant, they had taken oral antidiabetic drugs for long time or without treatment, and fewest were on insulin. Chief complaints of our patients were chest pain, epigastric pain, nausea and vomiting, weakness and dyspnea and faint. Fourteen percent of men and 30% of women had no chest pain on admission indicating to be careful about other symptoms of old diabetic patients with coronary artery disease.
S Moradmand , F Safari ,
Volume 56, Issue 6 (9 1998)
Abstract
Calcium channel blockers are used worldwide in CAD, hypertension and arrhythemia. As recent international studies show these drugs in addition to cardiovascular effects have immunosuppressive effects and can prolong graft life in transplanted patients. In a single blind prospective trial we studied 30 patients on 120 mg/d Verapamil for at least 3 months compared with 15 patients on placebo. Changes of cell immunity markers were impressive as T suppressor lymphocytes increased and CD4/CD8 ratio decreased significantly compared with placebo (P<0.05). This study confirms that Verapamil reduce cell immunity that may prone human beings to infections and on the other side we can use it in hypertensive patients with organ graft.
S Moradmand , M Rasooli Nezhad ,
Volume 58, Issue 1 (6 2000)
Abstract
Two factors changed the clinical course of infective endocarditis dramatically: 1) The discovery and evolution of techniques for identifying and treating its microbiologic causes and 2) Valvular surgery. We retrospectively evaluated 43 (33.5%) patients (8 female, 35 male) from 4 to 65 years old of 128 patients with infective endocarditis who underwent surgical intervention. Indication for surgery were: Refractory congestive heart failure 14 (32.5%), prosthetic valves 10 (23.2%), large vegetation 6 (13.9%), recurrent endocarditis 4 (9.3%), ring abscess 4 (9.3%), brucella endocarditis 2 (4.6%), staph aureus endocarditis 3 (6.9%) and recurrent emboli 2 (4.6%). 30 to 50% of patients with infective endocarditis are operated during the active phase of the disease, this percentage is higher in case of aortic valve endocarditis, prosthetic valve endocarditis, some microorganisms such as staph aureus, gram negative bacilli, fungus and brucella. We suggest that internists refer patients for surgical intervention with infective endocarditis as early as possible in the active stage of infection.
Moradmand S, Gharooni M, Javiani Ma,
Volume 58, Issue 2 (7 2000)
Abstract
Rheumatic heart disease is a serious health problem in developing countries. The present study was conducted to evaluate clinical and echocardiographic findings of Mitral stenosis and their relationship with patients functional classes. We studied records of 400 patients with symptomatic mitral stenosis (71% female, mostly in 20s or 30s and 54% function class II) treated in two hospitals in Tehran, Imam Khomeini and Amir-Alam Hospital, from 1994 to 1998. Clinical and echocardiographic data were extracted and analyzed. The most prevalent symptoms were dyspnea (96%), palpitation (41%) and chest pain (26%). Orthopnea, paroxysmal nocturnal dyspnea, hemoptysis and right heart failure were significantly correlated with functional class and severity of mitral valve stenosis (P<0.05). 41% of patients presented with atrial fibrillation at admission or during hospitalization. This arrhythmia had no relationship with age mitral valve area, although it was significantly correlated with left atrial diameter (P<0.05). Diagnosis and management of rheumatic heart disease need accurate physical examination and history taking and careful application of noninvasive and invasive procedures.
Moradmand S, Eshagh Hosseini Sm, Noori Sn,
Volume 59, Issue 1 (7 2001)
Abstract
This is a mortality study in internal medicine wards of Amir-Alam Hospital, since the beginning of 1374 to end of 1376. Here, we reviewed, prevalence of disease lead to death, the ward and invasive interventions and duration of admission of patients before death. In this study, records of 85 patients were reviewed. 68.2% of patients were men and 31.8% women. Mean of age was 61.6% with minimum of 18 and maximum 95 years. The most prevalent diseases leading to death were cardio vascular (41.2%), cancer 29.4%, GI tract diseases (10.6%), pulmonary diseases (8.3%), CNS (7.1%), hemathologic (4.7%), DM (3.5%). Mean duration of stay in hospital before death was 6.6 days (max 30-min 1). This figure in different wards were: ward 1 (7 days), ward 2 (11 days), ward 3 (5.9 days) ICU (5 days) and CCU (4.7 days). 90.5% of patients died due to their diagnosed illnesses. Invasive tests and intervations were performed in 40% of them. As a whole 35 patient were died in CCU. This research and others like it showes the failures of our patient management system and can guide us in approaching to better medical care.
Mahmoodi M J, Gharooni M, Moradmand S, Rezaei N,
Volume 60, Issue 5 (15 2002)
Abstract
Myocardial infarction sequel of coronary artery diseases, can be sometimes asymptomatic, called silent myocardial infarction. Some risk factors predispose the patients to this condition. In this study, we intend to determine the predisposing factors in such patients.
Methods and Materials: We included those patients with electrocardiogram changes, consistent with myocardial infarction, who had not any symptoms of ischemia or a previous history of coronary artery disease, consulted for preoperative work up of eye surgery during the year 2000.
Results: We analyzed 100 patients with the diagnosis of silent myocardial infarction. (59 males and 41 females). Among our patients. 99 percent were above age 50 years of age. Their mean age at the time of study was 69.7 years. 78 percent of patients were illiterate. In 41 of them body mass index was above the normal limits (overweight and obese). Their past medical history revealed that 46 patients had hypertension, 38 patients had hyper-lipidemia. and 26 patients had diabetes mellitus. Also, a positive family history of coronary artery disease was seen in 52 percent of the patients. The rate of cigarette smokers and opium addicts, among our patients, was 33 and 13 percents. respectively. Analysis of electrocardiogram changes, showed that 43 patients had inferior myocardial infarction, 24 had antero-septal. and 17 of them suffered from anterior myocardial infarction.
Conclusion: Almost all of our patients with silent myocardial infarction were in old age group. Diabetes mellitus, hypertension, overweight, hyper-lipidemia, and a positive family history of coronary artery disease were the most important predisposing factors, found in such patients, thus taking into account these predisposing factors and control of them would dramatically reduce the prevalence of morbidity and mortality of silent myocardial infarction.
Mahmoodi Mj, Gharooni M, Moradmand S ,
Volume 60, Issue 6 (15 2002)
Abstract
Introduction: Coronary artery disease (CAD) and its complications are the most prevalent etiology of mortality all over the world and diabetes mellitus (DM) is one of its risk factors. In this study prevalence of MI and unstable angina have been compared with different kinds of retinopathy and their severity.
Materials and methods: This study is a descriptive, cross sectional one that performed on 100 patients admitted in Imam, Farabi and Amir Alam Hospitals.
Results: Most important findings are as below: 1) Non-proliferative diabetic retinopathy (NPDR) are more prevalent than proliferative diabetic retinopathy (PDR), 41 Vs 17 cases, and 24 person were normal in MI population. And 12 persons had NPDR and 2 PDR and 5 normal in unstable angina. 2) Different diabetic retinopathy lesion were: 23 Venous dilation, 22 aneurysme, 18 hemorrhagic, 11 neovascularization, 10 macula edema, 6 retroretinal detachment, 2 gliosis. 3) on the point of presence or absence of diabetic retinopathy (DR), 72 percent had some kind of DR and 28 percent had nothing. Finally, in MI population 58 patients (70 percent) had DR and 24 patients (30 percent) didn't have any. In unstable angina 14 patients (77 percent) had diabetic retinopathy and 4 didn't have (23 percent).
Conclusion: Regarding the lack of facilities and shortcoming of necessary data, it was not possible to conduct a prospective investigation in this item, so the design and implementation of a prospective study based on enough cases and controls is strongly recommended.
Moradmand S, Shaeri H.r., Gharooni M, Rostamian A, Akbari Z, Mirkhani S.z., Bagheri A,
Volume 66, Issue 8 (5 2008)
Abstract
Background: Mitral valve prolapse is a relatively common valvular abnormality in most communities and joint hypermobility (JHM) is also seen in many healthy people as well as in certain clinical disorders, such as Marfan syndrome. The present study was designed to investigate the association between joint hypermobility and mitral valve prolapse (MVP) in an Iranian population sample.
Methods: Fifty-seven patients with nonrheumatic and isolated mitral anterior leaflet prolapse (24 men and 33 women, mean age 23.5 +/-2.3) and 51 healthy subjects (20 men and 31 women, mean age 22.9+/-2.3) were studied. The presence of JHM was evaluated according to the Carter-Wilkinson & Beighton criteria. Echocardiographic examination was performed in all subjects and the correlation between the echocardiographic features of the mitral valve and the hypermobility score were investigated.
Results: The frequency of JHM in patients with MVP was found to be significantly higher than that of controls (26.3% vs. 7.8%), with mean JHM scores of 3.1+/-2.2 and 1.9+/-1.7, respectively. The patients in the MVP group had significantly increased the anterior mitral leaflet thickness (AMLT, 3.4+/-0.4 mm vs. 3.0+/-0.3 mm p<0.0005) and maximal leaflet displacement (MLD, 2.4+/-0.3 mm vs. 1.5+/-0.2 mm p<0.0005) compared to the controls.
Conclusions: We detect a statistically significant relationship between isolated MVP and joint hypermobility as well as between the severity of JHM and echocardiographic features of the mitral leaflets. These results suggest a common etiology for MVP and JHM, which should be investigated in future well-conducted studies.
Rahimi A, Maziar S, Ahmadi F, Shahriari S, Fattahi F, Jam S, Moradmand Badie B, Kourorian Z,
Volume 66, Issue 9 (5 2008)
Abstract
Background: Anemia is a common complication accompanied by high morbidity and mortality in hemodialysis patients. Considering the fact that the reduction of erythropoietin (EPO) synthesis is the main cause of uremic anemia, receiving recombinant human erythropoietin (rHuEPO) can improve the condition in these patients. Some of these hemodialysis patients, however, have acceptable hemoglobin levels without any need to EPO. Higher BMI, higher albumin and leptin plasma levels and longer durations of hemodialysis are possible factors contributing to the reduced need for rHuEPO in these patients. The present study is designed to asses the relationship between the plasma levels of leptin and the reduced EPO need.
Methods: Fifty eligible hemodialysis patients with hemoglobin levels higher than 11 mg/dl were enrolled in the cross-sectional study. The information on age, sex, hemodialysis duration and the cause of renal dysfunction were extracted from the files. The baseline plasma levels of Leptin and albumin were measured. The patients BMI and the weekly need for rHuEPO were also calculated.
Results: There was no correlation between the weekly need for rHuEPO and sex, BMI, the cause of renal dysfunction and the plasma levels of albumin and leptin it, however, was related with age and the duration of dialysis. While age negatively influences the weekly need, the duration of dialysis has a positive effect on the need.
Conclusion: The plasma levels of leptin are not directly correlated with the required amounts of rHuEPO, indicating that leptin is not an effective factor in erythropoiesis. Conversely, older age and shorter hemodialysis durations are accompanied by reduced need for rHuEPO.
Hadadi A, Moradmand Badie S, Roham M, Rasulinejad M, Mirzai N,
Volume 67, Issue 8 (6 2009)
Abstract
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Background: One of the clinical manifestations of Human Immunodeficiency Virus (HIV)
infected patients is cardiovascular disorder. The aim of this study was to
evaluate the prevalence of cardiovascular disorders in HIV
infected patients for the beginning treatment of these patients and reducing
mortality and morbidity in these patients.
Methods: This cross-sectional study was performed on 134 HIV
infected patients who referred to Imam Khomeini hospital, Tehran University of
Medical sciences, Tehran Iran during years 2007-2008.
Demographic characteristics, history of smoking and opium addiction,
antiretroviral therapy, class of drugs and duration of consumption were
recorded. After completion of physical examination, electrocardiography and
echocardiography studies were done.
Results: In this study 98(73.1%) patients were male.
The mean age of the patients was 36.5±10.3
years. The mean of the CD4 number were 296±181. Injection drug users were 54.4%
of the study patients. Cardiovascular disorders were found in 84(62.7%)
patients. Among patients with heart diseases, 75%
were male. The most Electrocardiographic change was the axis deviation of the
heart found in 32(23.7%) patients.
Pericardial effusion and LVEF<50% were
noted in 7(5.2%) and 23(17.2%)
patients respectively. The involvement of the mitral valve
in 59(44%), tricuspid valve in 21(15.7%)
and aortic valve in 6(4.5%) patients were
noted. Myocardial dysfunctions existed in 10(7.4%)
patients.
Conclusions: Our results showed a high prevalence of cardiovascular disorder in HIV
infected patients. We recommend the evaluation of the cardiovascular
system in all HIV infected patients
even if they are symptom free.
Rasoulinejad M, Bouyer M, Emadi Kouchak H, Hasibi M, Mollazadeh N, Moradmand Badie B,
Volume 68, Issue 10 (5 2011)
Abstract
Background: Tuberculosis with high prevalence in HIV/AIDS
patients is the main reason for morbidity and mortality in these patients.
About one-third of patients with HIV infection
have concomitant tuberculosis. Lack of appropriate infection control on many
social and economic communities will impose. Comprehensive study on the effects
of anti-tuberculosis drugs in patients with HIV infecting
less done, also due to the importance of reducing morbidity and mortality,
reduce the cost of disease, identifying drug pharmacokinetics, the importance
of completing treatment tuberculosis, this study was performed to evaluate the
effects of anti- tuberculosis drugs on HIV infection
and to identify the drug pharmacokinetics and so more complete tuberculosis
treatment.
Methods: A historical cohort study was performed on
patients referring to the research center for HIV/AIDS,
consultation center, department of infection diseases of Imam
Khomeini Hospital
in Tehran, Iran. A
total number of 75 cases with HIV
negative versus HIV positive patients
with pulmonary tuberculosis and positive sputum smear in accordance with
inclusion and exclusion criteria were selected.
Results: In this study, the frequency of peripheral neuropathy 27(73%),
arthralgia 31(83.8%), vomiting 18(48.6%),
headache 26(70.3%), dizziness 20(54.1%),
renal toxicity 4(10.8%) and of skin rash 10(27%)
in patients with HIV virus infection were
significantly more than HIV- negative patients.
Hepatotoxicity, fever and anemia were not significantly more common in patients
who infected with HIV virus.
Conclusion: The HIV patients, who have not received antiretroviral
drugs during tuberculosis treatment, may show higher incidence of
anti-tuberculosis drugs complications.
Mehrnaz Rasoolinejad , Azar Hadadi , Mojtaba Hedayat Yaghoobi , Banafshe Moradmand Badie , Neda Alijani ,
Volume 71, Issue 7 (October 2013)
Abstract
Background: HIV infection reduces the immune system and is the most significant factor in the spread of TB in recent years and one of the causes of death in HIV -seropositive patients. TB is the most commonly diagnosed opportunistic infection and the most frequent direct cause of death among HIV infected patients. The HIV infection can accelerate progression of TB infection to active TB disease. Among patients with active TB, those with HIV co-infection have the greatest risk for relapse. Regardless of increasing rate of TB and HIV in Iran, we decided to s urvey outcome of TB in HIV positive patients who treated with standard regimens in the years 2003-2012.
Methods: This retrospective cohort study was conducted on HIV-positive patients with TB referred to Behavioral Diseases Consultation Center and Infectious Diseases Ward of Imam Khomeini Hospital from 2003 to 2012. Outcome was defined as failure, relapse and mortality. Moreover, the relationship between outcomes and number of CD4, co-trimoxazole and antiretroviral intake, type of TB and AIDS defining illness was studied. Results: This study had 135 patients, 8 (5.9%) were females and 127 (94.1%) were males. The mean age of the patients was 40.14+10.02 and the most way to catch HIV in this study was intravenous drug user. There were 3 (2.22%) cases of failure, 15 ( 11.1%) relapse , and 21 ( 15.8%) deaths. Antiretroviral therapy, AIDS defining illness, type of TB and co-trimoxazole intake did not soley affect relapse. CD4 level was the most effective variables in relapse [ Hazard ratio: 0.392 (0.11-1.4) Relative Risk: 0.809 (0.593-1.103) (P=0.068) ]. However, regard to CI95%, the impact of CD4 on relapse is not significant and antiretroviral intake was the most important and effective variable in increasing their survival. Hazard ratio: 0.137 (0.141-0.45) Relative Risk: 0.686 (0.513-0.918) (P=0.001) Conclusion: Overall, receiving antiretroviral was the most important factor influencing the outcome of patients. |
