Mostafavi F, Tavakoli M J,
Volume 61, Issue 1 (13 2003)
Abstract
Diabetes mellitus is the most common endocrine disease in childhood and adolescence. It has significant effects on growth and development of the involved patients.
Many studies have proved that in long term, diabetes causes an obviously decreased bone mass and linear growth in affected patients. Various studies have been done to determine the cause of these problems. In diabetic patients various degrees of calcium loss in urine have been detected.
Normally, the amount of calcium loss in urine of general population is less than 4 mg/kg/day, and the Ca/Cr ratio in a random urine sample is less tan 0.25.
Hypercalciuria may be the underlying cause of osteopenia and linear growth defect in diabetic children.
In our study, the urinary calcium loss of 50 diabetic children was determined. We tried to find a correlation between the amount of calcium loss in urine and plasma glucose.
These patients have been referred to Children's Medical Center during a 6 month period in year 2000. They had very higher incidence of hypercalciuria than the non-diabetic population, but we found no significant correlation between the severity of hypercalciuria and seventy of hyperglycemia in them.
