Nateghpour M M, Edrissian Gh, Torabi A, Raesi A, Motevalli-Haghi H, Abed-Khojasteh N, Ghobakhlo N,
Volume 67, Issue 3 (5 2009)
Abstract
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Background: Malaria is an
important parasitic vector-borne disease with considerable infectivity and
world-wide distribution. Since prevalence of chloroquine resistance in Plasmodium
falciparum at the malarious areas such as Iran
and reliable reports from many countries indicating emergence of chloroquine-
resistant strains of P.vivax, this study was conducted to monitor the
current response of vivax and falciparum plasmodia to chloroquine
in Bandar-Abbas district, a malarious area in Iran.
Methods: The study was
conducted at the Bandar-Abbas district in Hormozgan province, Iran. 123 patients were
enrolled and considered. The patients were treated with a standard 3-day regimen of
chloroquine and were followed-up clinically and parasitologically. The results
were interpreted as mean parasite clearance time (MPCT) in P. vivax and early
treatment failure (ETF), late treatment failure (LTF) and adequate clinical and parasitological response (ACPR) in P. falciparum.
Results: The patients with
vivax malaria were responded to the regimen of chloroquine within 24-216 hours. Most cases of
the parasite clearance time occurred at 48 hours (50.40%), and less of them at 120, 168, 192 and 216 hours with 0.81% for each of them. MPCT in this study was
calculated as 61.07 (±26/47) hours for all of the patients. 33.33% and 66.66% of the patients with falciparum malaria
were found at ACPR
and LTF groups, respectively.
Conclusion: This study confirms the efficacy of chloroquine on P.vivax.
The extended parasite clearance time in a number of patients may be an early
sign for reduced susceptibility of P.vivax to chloroquine in the studied
areas. Most of the patients with falciparum malaria (66.66%)
considered in this study did not respond to the regimen of chloroquine because
of chloroquine- resistance in P.falciparum at the area.
Af Zand Parsa, N Gilani Larimi, A Esteghamati, M Motevalli,
Volume 71, Issue 2 (5 2013)
Abstract
Background: It has been shown that coronary artery calcium scoring (CACS) can be used as a diagnostic method in coronary artery disease (CAD). The relationship between CACS and calcium metabolism in the body has been shown. The arterial calcification is an organized process similar to bone formation which is controled by parathormone (PTH). The relationship between PTH as an osteoregulatory factor and CACS has been also indicated. In this study, we tried to assess the value of serum PTH and CACS in patients planned to undergo coronary angiography (CAG) in order to find a simple, cost -benefit, noninvasive way, for ruling in/out obstructive CAD.
Methods: In a cross sectional study in Imam Khomeini hospital in 1390, CACS by using non-enhanced multi detector computed tomography (MDCT) and measurement of serum level of PTH, Calcium and Phosphate were done in 178 patients suspected to CAD which were scheduled to undergo coronary angiography serum PTH was measured by immuno-radiometric assay (IRMA) and serum Ca and Phosphate were measured by spectrophotometry methods.
Results: Of 178 Patients, 50 patients were females and 126 patients were male. Mean age of them was 56.2±11.6. The correlation coefficient between CACS and Gensini score (0.507, P<0.001), PTH (0.037, P=0.693), Ca (0.062, P=0.499) and Phosphate (0.061, P=0.506) were obtained. The level of serum PTH in the patients with and without coronary artery disease were 21.8±11.6 pg/dl, 23.2±11.5 pg/dl (P=0.427) respectively.
Conclusion: Our study showed association between CACS and CAD that was statistically significant while no relationship was found between PTH, CACS and CAD.
Mahboobeh Hajabdolbaghi , Hamid Emadi Kochack , Mohammad Reza Salehi , Seyed Ali Dehghan Manshadi, Mehdi Usefipour , Afsaneh Motevalli Haghi ,
Volume 73, Issue 4 (July 2015)
Abstract
Background: One of the main reasons of hemorrhagic fevers is Ebola. The high rate of mortality and lack of definite treatment have been caused this infection to be a serious problem in the world. Ebola, especially in the early stages, when causes symptoms such as fever, anorexia and nausea, can be confused with malaria infection and conversely, severe malaria with Ebola. Plasmodium falciparum is an important cause of severe malaria that more than other types of plasmodium confused with Ebola.
Case presentation: The patient is a 54-year-old man who had gone to Sudan about 8 months ago. The patient reported that fever, chills and headache had been started one week before traveling from Sudan to Iran and hematuria was added to his symptoms in third week of illness in Iran. He was referred to the emergency department with probable diagnosis of Ebola. Plasmodium falciparum gametocytes were revealed in his peripheral blood smear. Finally, he was treated with Coartem (artemether/lumefantrine) for malaria and after clinical improvement discharged to home with good condition.
Conclusion: Ebola should be suspected in every patient with fever and a history of traveling to endemic areas. Considering the fact that in most areas where Ebola is endemic also malaria is common, lack of clinical suspicion to malaria causes that clinicians mistake malaria with Ebola. Necessary laboratory tests to rule out important differential diagnoses in patients with suspected Ebola virus contains: Peripheral blood smear for malarial parasite and blood culture and blood cell counts to investigate typhoid fever and other bacterial infections. Therefore, malaria should be considered as an important differential diagnosis in every patient suspected with Ebola.
