Showing 10 results for Naseri
I Fatehi , Z Noroozi , M Naseri ,
Volume 56, Issue 3 (1 1998)
Abstract
In this study we review 82 infants under two months with bacterial meningitis admitted in Tehran University's hospitals during a 14 year period. Male to female ratio was 1.4 to 1. The patterns of predominance among bacterial pathogens changed during the period of study. During the first six years the most common pathogens were Salmonella-SP., but during the later years E.coli became the predominant pathogen, and also meningitis caused by GBS and Staph. epidermidis was observed. The case fatality rate was 37.8 percent. The antibiogram revealed that E.coli were hundred percent resistant to ampicillin and 50% resistant to gentamicin, 40% of all bacteria isolated were resistant to ampicillin and gentamicin. These findings provide guidelines for the selection of empiric antimicrobial agents in our country
Ahmadi F, Naseri R, Lessan Pezeshki M,
Volume 66, Issue 7 (6 2008)
Abstract
Normal
0
false
false
false
EN-US
X-NONE
AR-SA
MicrosoftInternetExplorer4
Background: Cyclosporine
is one of the main immunosuppressors used for renal transplant recipients, and
is given to prevent transplant rejection. Although the drug increases the
survival of patients and grafted organs, it has some side effects independent
of its effect on the immune system that are usually ignored. In this study, we
evaluate the effect of cyclosporine on serum Mg levels and metabolic side
effects in renal graft patients.
Methods: In this study, we followed 157 renal
transplant recipients (62 females and 95 males) who were being treated with cyclosporine at a
private clinic to prevent transplant rejection. The patients were first physically
examined and then blood samples were obtained in order to measure levels of
cyclosporine, Mg, creatinine, fasting blood sugar, lipids, calcium,
phosphorus, and uric acid levels. We then analyzed the data for correlations between
serum Mg
levels, cyclosporine and other metabolic complications.
Results: The mean levels of Mg and
cyclosporine were 196±0.31mg/dl and 371±192 μg/dl, respectively. Hypomagnesemia was detected in 16 patients (10.2%).There was
a significant negative correlation (p<0.05) between levels of Mg and cyclosporine levels (r=-0.53), serum
creatinine (r=-0.61), plasma LDL (r=-0.3), fasting blood sugar (r=-0.60) and uric
acid (r=-0.36), and no correlation (p>0.05) between levels of Mg and calcium (r=0.2), phosphorus (r=-0.01),
triglycerides (r=0.06) and HDL (r=-0.08). Mean levels of cyclosporine, creatinine, LDL, fasting
blood sugar and uric acid in patients with hypomagnesemia were significantly
different from those patients with normal serum Mg levels (p<0.05). There
was no significant difference between the two groups with regard to mean total
cholesterol, HDL, calcium and phosphorus (p>0.05).
Conclusion: According to the results of this and previous studies,
there is a significant correlation between cyclosporine levels and
hypomagnesemia as well as other biomedical complications secondary to
hypomagnesemia. Therefore, we recommend routine serum Mg determination and greater
attention to hypomagnesemic patients to prevent further complications.
Ali Zamani, Alireza Karimi, Mohsen Naseri, Elaheh Amini, Mohammad Milani, Amir Arvin Sazgar, Seyed Mousa Sadr Hosseini, Mohammad Sadeghi Hassan Abadi, Fatemeh Nayeri, Firouzeh Nili, Mamak Shariat, Mostafa Vasigh, Fariba Nasaj, Fatemeh Zamani, Narges Zamani,
Volume 68, Issue 1 (4 2010)
Abstract
Normal
0
false
false
false
EN-US
X-NONE
AR-SA
MicrosoftInternetExplorer4
Background: American pediatric Association proposes to
screen all neonates with Oto-Acoustic Emission (OAE). In developing countries, because of several limitations,
health policy makers recommend to screen only in high risk patients. This study is performed with the aim to screen
hearing loss in 950 high risk newborns hospitalized in hospitals
affiliated to Tehran University using the OAE test.
Methods: A total of 950 neonates hospitalized in the Neonatal and NICU wards of
Vali-e-Asr, Shariati, Medical Center and Bahrami Hospitals during the years 2004-2006 who
showed at least one risk factor using TEOAE hearing test were enrolled into this cross-sectional
descriptive analytical study and were diagnosed with mild deafness and total
deafness. Blood exchange due to hyperbillirubinemia, septicemia, congenital
heart disease, the fifth minute apgar scores below six, PROM more than six hours, epilepsia, need to NICU more than five hours, pneumonia and Oto-Toxic drugs
were considered as risk factors. Data was past medical history, current
disease, admission cause, sign & symptoms and complications of disease.
Results: Multivariate logistic regression and paired t-test
showed that blood exchange, low birth weight and low first minute Apgar scores
had the highest independent risk for hearing loss among newborn.
Conclusion: Despite of the low prevalence of neonatal hearing loss,
screening of hearing loss at early stages is important.
Faghihloo E, Rezaie F, Salimi V, Naseri M, Mamishi S, Mahmoodi M, Mokhtari-Azad T,
Volume 68, Issue 3 (5 2010)
Abstract
Background: Human respiratory syncytial virus (HRSV) is the most important viral agent of acute lower respiratory tract disease in infants and young children worldwide. This virus is responsible for 50% brochiolitis and 25% pneumonia in infants. There are limited data of molecular epidemiology of HRSV from developing countries. This is the report on the molecular epidemiology of human respiratory syncytial virus in Iran. Methods: In this study, RT-PCR for second hypervariable region of the HRSV G glycoprotein was performed on 72 throat swabs collected from children less than 5 years of age with acute respiratory symptoms in 1386.
Results: Of the 72 throat swabs collected from children with acute respiratory symptoms, 14 (19.44%) were positive for HRSV. Phylogenetic analysis revealed that all HRSV-positive samples clustered in three genotypes of subgroup A: 12 strains (85/71%) in genotype GA2, 1 strain (7/1%) in genotype GA1, and 1 strain (7/1%) in genotype GA5. In this study we couldn’t identify any genotype of subgroup B.
Conclusion: Our results revealed that multiple genotypes of subgroup A were co- circulated during 1386 in children less than 5 years of age in Iran. Also this study revealed that genotype GA2 was predominant genotype in isolates were obtained from several cities (Tehran, Isfahan, Karaj, Qazvin, Bandar Abbas, Shahreza), so we speculate that this genotype may be predominant during 1386 in Iran. This study supported that RT-PCR for second variable region of G protein is an effective method for further studies of HRSV genotype designation in Iran.
Shatizadeh Malekshahi S, Yavarian J, Naseri M, Rezaei F, Mokhtari Azad T,
Volume 68, Issue 9 (6 2010)
Abstract
Background: Respiratory virus infections represent a major public
health problem because of their worldwide occurrence, ease of spread in the
community and considerable morbidity and mortality. They are one of the most
common reasons for hospitalization of children under the age of six. In some
cases, infection with two different viruses increase the severity of disease
which lead to the hospitalization.
Case presentation: Among 202 samples related to children under the age of six
with respiratory infections, two dual infections of Adenovirus with other
respiratory viruses with PCR test were
detected.
Conclusion: Mixed respiratory viral infections are sometimes
associated with severe disease and recognition of coinfection is important. Dual infections of Adenovirus with respiratory syncytial
virus (RSV) and
Swine origin influenza A (H1N1) virus
were demonstrated. The evidence showed that the co-infection of Adenovirus with
swine origin influenza A (H1N1), has
increased the severity of disease which lead to the hospitalization.
Mohagheghi A, Mohebi M, Kamal Hedayat D, Tabatabaee A, Naseri N,
Volume 69, Issue 6 (6 2011)
Abstract
Normal
0
false
false
false
EN-US
X-NONE
AR-SA
MicrosoftInternetExplorer4
Background: This study was designed to explore the contribution of risk factors for
coronary artery disease (CAD) in patients with
indication for coronary angiography. Coronary angiography is defined as the
radiographic visualization of the coronary vessels after injection of radio
opaque contrast media. Despite the recognition of risk factors for
CAD, the association between related risk factors and angiographic
findings remains controversial. The aim of the present study was to explore the
association between Gensini scores and major cardiovascular risk factors in
patients with indications for coronary angiography.
Methods: We retrospectively enrolled 495 patients who had
been hospitalized at Dr. Shariati Hospital during September 2009
to September 2010 and had undergone
coronary angiography. The patients were evaluated for the severity of coronary
lesions on the angiogram by Gensini scoring system. The patients were also
evaluated for the presence or absence of DM,
hypertension, family history of cardiac diseases, low HDL,
hyperlipoproteinemia, hypertriglyceridemia and cigarette smoking. Statistical
analysis wad done to find any relationship between Gensini scores and cardiovascular
risk factors.
Results: The study population consisted of 249
men (50.3%) and 245
woman (49.5%) with a mean age of 58.1±10.3
years. A positive correlation
was found between age (P=0.04), sex (P=0.008),
HDL (P=0.04) smoking (P=0.0001)
and diabetes (P<0.013) with Gensini scores.
Conclusion: In
patients with indications of angiography, Gensini scores provide valuable
prognostic information on cardiovascular risk factors. Age, sex, HDL, smoking
and diabetes are related to the severity of coronary
lesions on the angiograms.
Sharifi A, Dolatshahi Sh, Naseri H, Ramim T,
Volume 70, Issue 12 (5 2013)
Abstract
Background: Percutaneous endoscopic gastrostomy (PEG) is one of the ways to non-oral feeding in patients with dysphagia caused by conditions such as stroke, oropharyngeal malignancy and motor neuron disease. The aim of study was assessment of early outcome of PEG in hospitalized patients according to clinical situation and underlying disease.
Methods: This study was cross- sectional and prospective. Sixty five patients were included with PEG from April 2011 to July 2012, at Sina University Hospital, Tehran, Iran. Tube function, feeding, and patients' symptoms were assessed and patients were followed six month at least to one year after procedure .The follow up of patients were stopped if the patient died or removal of tube.
Results: Sixty five patients (33 men, 32 women) enrolled in this study. The mean age of patients was 57.45±16.83 years (19-94 years). Head trauma and postoperative thoracic surgery were in 15 (23.1%) and 4 (6.2%) cases. 36 of patients (55.39%) had no symptoms. The complications include lickage (11 cases), stenosis (9 cases), cellulitis (7 cases), and PEG separation (2 cases). A total of 29 patients were complicated and 21 patients (72%) of them complicated 2 -5 months after PEG. No statistical significant differences between two sexes in PEG complication. 27 patients (41%) died that have no relation to complications of PEG.
Conclusion: Finally, the study showed the PEG is a safe method to enteral nutrition. The advantages of this method include its simplicity, no need to general anesthesia and low rate of complications especially in inpatient under the supervision of medical staff. Therefore it can be used as a favorable method.
Roya Mahdavi, Mitra Jamali, Mehdi Rostami, Amin Safa, Abdollah Jafarzadeh, Mohsen Naseri,
Volume 74, Issue 6 (September 2016)
Abstract
Background: Multiple sclerosis (MS) is a chronic inflammatory disorder of the CNS characterized by destruction of the myelin sheath, gliosis and progressive neurological dysfunction. The regulatory T (Treg) cells play a major role in the control of the autoimmunity and inflammation. The forkhead box p3 (FOXP3) is a central molecule in the function of Treg cells that play an important role in the immunoregulation. The aim of this study was to investigation single nucleotide polymorphism (SNP), rs2232365, in FOXP3 gene in patients with multiple sclerosis.
Methods: In a case-control study, peripheral blood samples were collected from 90 patients with MS (46 men and 94 women with different patterns of disease) from January 2014 to April 2015 in the Afzalipoor Hospital, Kerman (a city located in the southeast of Iran). In a total, 90 healthy subjects were also enrolled into the investigation as a control group. The healthy subjects were recruited among blood donations of the Kerman Transfusion Organization and interviewed regarding CNS disease, and none of them had any history of CNS diseases or other relevant disorders. The SNP rs2232365 in FOXP3 gene was assessed by single specific primer-polymerase chain reaction (SSP-PCR) method. Finally, statistical analysis was performed using SPSS version 22 (Chicago, IL, USA).
Results: In both patients and healthy control groups, there was significant difference among subjects with GG, AG, and AA genotypes at rs2232365 in FOXP3 gene. The frequencies of AA and AG genotypes at rs2232365 in the FOXP3 gene were significantly higher in MS group as compared with healthy subjects (P<0.002). Moreover, the frequency of GG genotype was significantly lower in the MS group in comparison with healthy control subjects (P<0.002). The frequency of A allele was significantly higher whereas the frequency of G allele was significantly lower in MS patients as compared with healthy subjects (P<0.001).
Conclusion: The results of the present study suggest that SNP rs2232365 may influence the susceptibility to multiple sclerosis. Therefore, SNP rs3761548 may directly or indirectly alter the level of the FOXP3 protein expression in Treg cells.
Farzaneh Naserian , Fatemeh Heshmati , Maryam Mehdizadeh Omrani, Reza Salarian ,
Volume 76, Issue 4 (July 2018)
Abstract
Today, nanoscience has grown and developed in various medical and therapeutic areas, including cancer treatment. On the other hand, cancer and its types have been rumored and inclusive and many people suffer from this fatal and deadly disease. Currently, existing therapeutic method, including chemotherapy, radiotherapy, and etc., along with the therapeutic effect, cause complications that are unpleasant for patients. Hence, scientists and researchers are looking to develop and improve treatment options and methods to deal with this serious disease. Today, nanoscience and nanotechnology have become widespread, and its various fields, including nanoparticles, are widely used for a variety of applications, especially for delivery of drugs and diagnostic items and imaging cases. Nanotechnology-based release systems have a significant impact on the release of cancer drugs. Advances in bio-materials and bio-engineering are contributing to new approaches to nanoparticles that may create a new way for the improvement of cancer patients. Nano-technology in the drug release system has had a great impact on the selection of cancer cells, the release of a targeted drug, and overcoming the limitations of conventional chemotherapy. At the present many drug delivery systems are now made of nanoparticles, and various substances have been used as drug-stimulating agents or as a reinforcing agent to improve the efficacy of the treatment and durability and stability and also the safety of anticancer drugs. The materials used to release cancer drugs are divided into various categories such as polymer, magnetic, biomolecules. In the meantime, polymer nanoparticles have been organized in the carriers of anti-cancer nanoparticles due to the process of easy production, biocompatibility, and biodegradability. Although the loading of hydrophilic compounds is still confronted with limitations, due to the diversity of nanoparticle structures, it is possible to encapsulate various molecules. Also, surface changes and modification such as binding to antibodies and target ligands can also be applied to these materials, to act as target drug delivery to increase the effectiveness of treatment process. In this article, we will have an overview of cancer disease and cancer drugs and also nanoparticles and their contribution to cancer treatment.
Kambiz Javadzadeh Siahkelrodi , Shahpour Shoja, Karim Naseri, Farzad Sarshivi, Shahrokh Ebnerasouli, Mohamad Aziz Rasouli , Shaho Shoja ,
Volume 79, Issue 7 (October 2021)
Abstract
Background: Bier block is a reliable technique used in extremity surgeries. Typically, angiocatheters are palced in the distal portion of the extremity that is going to be operated. Although, it is not the case in every operation. Therefore, determining the effectiveness of the local anesthetic injection site on the quality of the upper-extremity block can be helpful.
Methods: In this double-blinded randomized clinical trial that took place in Kowsar Hospital (Sanandaj, Iran) at 2020, 60 patients after complete monitoring and sedation were assigned randomly into proximal bier block (32 in experimental) and distal bier block (28 in control) groups. 10ml/kg Ringer serum was prescribed for patients in both groups on the non-surgical hand. Depending on the patients’ placement in either group, an angiocatheter (22 or 24) was attached to the ante-cubital area (proximal bier block group) or on the back of the patient's hand (distal bier block group). Respectively, after blood was drained by a Smarch band from the extremity that was to be operated, the tourniquet was inflated up to 150mmHg above the patient’s systolic pressure and the smarch band is untied from the hand. For every patient regarding the group they were assigned, 3mg/kg lidocaine 0.5% was administered through an angiocatheter. After 5 minutes, the depth of patient's anesthesia and pain intensity were measured. Sensory and motor recovery was assessed every 10 minutes after surgery. Patient satisfaction with anesthesia was measured after the surgery and characterized by excellent, good, moderate (pain relief), and unsuccessful (need for pain medications) indicators. In case insufficient depth was reached, intravenous Remifentanil was injected.
|
Results: According to the results of the chi-squared test, there were no significant differences in gender distribution (p=0.063), anesthesia class type (p=0.964), type of surgery (p=0.694), anesthesia satisfaction (p=0.578), sensory block of hand (p=0.529), motor block of hand (p=0.059), pain intensity (p= 0.634), pain relief medication requesting (p=0.755) and also body mass index (T-test used P=0.099) variables comparing both groups together. Additionally; according to the T-test results no significant differences were reported in the mean systolic pressure, mean diastolic pressure and mean heart rate variable in designated times.
Conclusion: There is no significant difference between the two groups. Therefore, using a distal Bier block can be an alternative if needed.
|
