Showing 6 results for Nategh
M Mir , F Nateghi , H Zeraaty ,
Volume 56, Issue 5 (6 1998)
Abstract
In this paper, factors affecting the result of prophylactic lymph node dissection in 125 patients with skin melanoma during the period between 1987-1992 in the cancer institute were evaluated and prognostic parameters ascertained. The result showed prevalence of head and neck melanoma in men were two times more than in women with a preponderance of regional and lymphatic recurrence. Majority of patients presented with advanced clark levels (76.8 Pct). Clinical and histologic evaluation of the regional lymph nodes failed to show any meaningful relation.
T Mokhtari Azad , H Mohammadi , M Mahmoodi , Z Saadatmand , A Moosavi , R Hamkar , R Nategh ,
Volume 57, Issue 2 (8 1999)
Abstract
This is a report of the first serological survey of influenza C virus in Iran, performed during a one year period (March 1997-May 1998). This study was accomplished in the National Influenza Center-Division of Virology in Tehran University of Medical Scinces. 1080 samples of serum (689 samples from Tehran and 391 samples from other provinces) were assayed for the presence of antibodies against influenza C virus (C/Paris/1/67) by haemagglutination inhibition (HI) test. 43.7% of people tested in Tehran and 40.7% of people tested from other provinces had protective antibodies against influenza C virus. Distribution of seropositives in various age groups had a somewhat similar pattern as what has been reported from other countries. The results of this study indicates that the lowest level of protective antibody titer is found at childhood and the level increases with age. The protective antibody titer level off for 20-30 years old age group and decreases in older age groups. These results indicates a primary contact in childhood, reinfection in adulthood. The influenza C virus is simultaneously circulating in Iran with other types of influenza viruses (types A and B).
Doosti S, Basseri H.r, Nategh Pour M, Akbarzadeh K, Ladoni H, Shaeghi M,
Volume 64, Issue 12 (6 2006)
Abstract
Background: Although there have been many studies on the role of mosquitoes in malarial transmission, the biology and interaction of plasmodium with its host is still not completely known. The aim of this study was primarily to follow the sporogony cycle of Plasmodium vivax in Anopheles stephensi mysorensis and then to explore the inhibitory effects of certain carbohydrates on parasitic development.
Methods: In a restricted insectary, An. stephensi were fed blood containing gametocytes from donor malaria patients. The development of plasmodium was followed by dissecting the infected mosquitoes and taking a smear at different time intervals. Other groups of Anopheles were fed infected blood plus one of the following carbohydrates: N-acetyl-glucosamine, N-acetyl-galactosamine, arabinose, fucose, manose, lactose or galactose.
Results: Exflagellation occurred at 5 minutes after the blood meal and then ookinet was observed at 20 hours, while oocysts and sporozoites appeared in days 8 to 12. The results indicate that An. stephensi strain mysorensis has can transfer P. vivax extremely well. Furthermore, the development of P. vivax was completed in the mosquitoes that had been fed with N-acetyl-glucosamine, arabinose, fucose and galactose. In contrast, lactose, mannose and N-acetyl-galactosamine interrupted the life cycle of the parasite.
Conclusion: The sugars lactose, mannose and N-acetyl-galactosamine have an inhibitory role in of oocyst and sporozoite development. Therefore, the results of this study can be used as basic information for inhibiting malarial transmission.
Azadibakhsh N, Shaker Hosseini R, Atabak Sh, Nateghiyan N, Golestan B, Houshiar Rad A,
Volume 65, Issue 8 (3 2007)
Abstract
Background: Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. The frequency of hyperhomocysteinemia is higher in hemodialysis (HD) patients than the general population. The objective of this study is to assess the efficacy of high-dose folic acid supplementation with and without vitamin B12 on lowering plasma total homocysteine (tHcy) concentrations in HD patients.
Methods: Thirty-six HD patients at Imam Hossein Hospital, Tehran, Iran, who had been given folic acid supplements (5 mg/d) for at least 3 months before, were enrolled in this clinical trial. Subjects were also checked for other inclusion and exclusion criteria. The subjects were divided randomly into four groups and underwent two months of supplementation as follows: 5 mg/d oral folic acid + placebo in group one, 5 mg/d oral folic acid + vitamin B12 (1 mg/d orally) in group two, 15 mg/d oral folic acid + placebo in group three and 15 mg/d oral folic acid + vitamin B12 (1 mg/d orally) in group four. Concentrations of plasma tHcy and serum folic acid and vitamin B12 were measured at baseline and after the supplementation period. Dietary intake of patients was also determined during the supplementation period.
Results: Of the folic acid supplemented patients, 27.8% had normal levels of tHcy at baseline and 72.2% had hyperhomocysteinemia. After the supplementation period, plasma tHcy increased by 1.35% in group one and decreased by 6.99%, 14.54% and 30.09% in groups two, three and four respectively. Changes in plasma tHcy and serum vitamin B12 were only significant in group four however, no significant changes were seen for serum folic acid. The percentage of subjects reaching normal levels of plasma tHcy was 5.6 fold higher in group four than in the reference group.
Conclusions: Supplementation with 15 mg/d folic acid together with 1 mg/d oral vitamin B12 is more effective in reducing tHcy levels in HD patients.
Nateghpour M M, Edrissian Gh, Torabi A, Raesi A, Motevalli-Haghi H, Abed-Khojasteh N, Ghobakhlo N,
Volume 67, Issue 3 (5 2009)
Abstract
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Background: Malaria is an
important parasitic vector-borne disease with considerable infectivity and
world-wide distribution. Since prevalence of chloroquine resistance in Plasmodium
falciparum at the malarious areas such as Iran
and reliable reports from many countries indicating emergence of chloroquine-
resistant strains of P.vivax, this study was conducted to monitor the
current response of vivax and falciparum plasmodia to chloroquine
in Bandar-Abbas district, a malarious area in Iran.
Methods: The study was
conducted at the Bandar-Abbas district in Hormozgan province, Iran. 123 patients were
enrolled and considered. The patients were treated with a standard 3-day regimen of
chloroquine and were followed-up clinically and parasitologically. The results
were interpreted as mean parasite clearance time (MPCT) in P. vivax and early
treatment failure (ETF), late treatment failure (LTF) and adequate clinical and parasitological response (ACPR) in P. falciparum.
Results: The patients with
vivax malaria were responded to the regimen of chloroquine within 24-216 hours. Most cases of
the parasite clearance time occurred at 48 hours (50.40%), and less of them at 120, 168, 192 and 216 hours with 0.81% for each of them. MPCT in this study was
calculated as 61.07 (±26/47) hours for all of the patients. 33.33% and 66.66% of the patients with falciparum malaria
were found at ACPR
and LTF groups, respectively.
Conclusion: This study confirms the efficacy of chloroquine on P.vivax.
The extended parasite clearance time in a number of patients may be an early
sign for reduced susceptibility of P.vivax to chloroquine in the studied
areas. Most of the patients with falciparum malaria (66.66%)
considered in this study did not respond to the regimen of chloroquine because
of chloroquine- resistance in P.falciparum at the area.
Saeed Nateghi, Forough Goudarzi , Samad Taghavi Namin , Atefeh Rasouli , Akram Khalili Noushabadi, Safieh Mohammadnejhad ,
Volume 79, Issue 9 (December 2021)
Abstract
Background: Age is a strong risk factor for increasing the risk of severity and death from Covid-19. The risk of hospitalization for Covid-19 disease increases with age. Since the elderly constitute a large proportion of Covid-19 patients, the present study was performed to evaluate the severity of the disease in the hospitalized elderly due to Covid-19 and the delay in hospitalization and death resulting from it, for better disease management.
Methods: The present retrospective cohort study was performed on 444 elderly patients with Covid-19 admitted from 1 April until late October 2020 in Baharloo Hospital in Tehran, Iran. After being diagnosed using the results of RT-PCR and CT scan, patients, were divided into 3 groups: moderate, severe and very severe based on the severity of the disease. Analysis of variance was used to compare quantitative data and a chi-square test was used to examine qualitative variables in disease groups.
Results: From 444 elderly participants in the study, 73% were infected moderately, 15% severely, and 12% had a very severe form. The mean age was 72.90±8.42 and patients with a very severe form of the disease (75.68±8.28) were older. The average time from the onset of symptoms to hospitalization was 7 days. In the elderly with a very severe form of the disease, respiratory dyspnea (P=0.002) and decreased level of consciousness (P<0.0001) were higher. The average hospital stay was 7 days. In very severe form it lasted up to 11 days. ICU mortality and hospitalization were higher in patients with very severe forms of the disease. With the increasing delay in the days of hospitalization, the severity of the disease and mortality has increased.
Conclusion: The study showed that prolonging the onset of symptoms till hospitalization worsens prognosis and also exacerbates the disease and increases mortality in the elderly.
