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Background: Neuronal injury in hippocampus is the most
common pathological finding in temporal lobe epilepsy, accounting for
approximately 70% of cases in patients
with epilepsy. Neuroprotective
effects of aspirin have been described in several neurodegenerative diseases. The
aim of this study was to explore effects of aspirin on morphology and number of
pyramidal neurons in CA1 and Dentate
Gyrus area of hippocampus of rats in kindling
model of epilepsy.
Methods: We divided the rats into t hree groups (n=8).
Two groups received aspirin (30
mg/kg, p.o.) and saline, one week
before and during induction of kindling. Kindling was induced in these groups
by administration of pentylenetetrazole (PTZ: 40 mg/kg,
ip). The
third group received only saline throughout the study and served as health
control group. After induction of
kindling animals were sacrificed by perfusion with 10%
saline solution under anesthesia. Histopathologic
study of hippocampus were performed by light microscopy using H&E
staining.
Results: A large number of injured pyramidal neurons with
pyknotic nuclei and high eosinophilic cytoplasm are seen in CA1
and DG area of hippocampus of epileptic control
group. Aspirin group had
pyramidal neurons with clear nuclei and less density cytoplasm, similar to
health control group (p<0.05).
In kindled animals the number of intact
pyramidal neurons in these two regions were significantly reduced and this
effect was counteracted by aspirin (p<0.05).
Conclusions: Results of present study suggest that aspirin
have neuroprotective effect against neuronal damage of hippocampus of kindled
animals.
