Tehran University Medical Journal

---

---

57 cases of jaw's SCC who were hospitalized in Imam Khomeini HSP, Amir-Alam HSP & Cancer Institute between the years of 1373 to 1376, were studied. 23 cases of them were female and the rest of them (34 cases) were male. The range of age of patients was between 25 to 85 years. 21 cases (36.8%) have maxillary involvement and 37 cases (64.9%) have mandibular involvement and there was one case (1.7%) of synchronous involvement of both sites. Patients were categorized according to their individual characteristics (sex, age, occupation, birth & living place), etiologic factors (smoking & familial susceptibility), complaints, sites of involvement in each jaw, histopathological characteristics of tumor (stage, grade, lymphatic involvement), rate of bone and soft tissue involvement, type of treatment, and recurrences of previous lesions. According to the results, and apart from late consultation of majority of patients with their physicians, invasive behaviours of tumoral lesions were less than expected rate. And despite of using radical and invasive treatments, considerable percent of patients were facing recurrence of their previous lesions. Besides, patterns of distribution of birth and living places of patients may probably show the role of geographical and environmental factors in making patients susceptible to certain diseases.

---

The subglot stenosis can be congenital or acquired. The prevalence of this disorder is low but due to seriousness of the disease and lake of an effective treatment it is considered as major issue in otolaryngology. The most important cause of this disorder is trauma due to prolonged intubation of larynx. The aim of this study was to describe the etiologic, clinical manifestation and the therapeutic procedures in patients with subglot stenosis who referred to Imam Khomeini and Amir Alam Hospital during years 1371 through 1376. Sixty-two patients, 44 (71%) men and 18 (29%) women were investigated. The youngest patient was 1.5 years and the oldest was 76 years. The most frequent symptoms were striodor and shorthness of breath. The main etiologic factor was prolonged intubation in younger patients and neoplastic disorder in patients over 40 years. In 62% of subject intubation lasted more than 7 days and the resting less than 7 days. The most frequent endoscopic finding was granulated tissues. Ninety-one percent of subjects had trachestomy. In terms of treatment 44% had been given antibiotics. We conclude that care must be given to these patients to change the graft more frequently and to have antibiotic as a treatment regimen after trachestomy to reduce infection

---

Approximately 15% of sogt-tissue sarcomas occur in head neck area and sarcma should be considered in the differential diagnosis of any tumor mass in this anatomic region, especially in younger patient. This was a retrospective study that reviewed all head and neck sarcoma cases registered at Imam Khomeini Hospital and Cancer Institute during the period 1987-1996. Using medical records, relevant informations including demographic, medical and risk factors were collected. Analysis of data on 40 eligible cases revealed, age range of 31-40, yearsmale sex and residence in cities as risk factors. Osteosarcoma was the most frequent pathology and painless mass was the most frequent sign in all histologic subtypes. In 80% of cases the tumors were primary and in 42.5% the disease recurred after treatment.

---

Background: Thyroid cancer is a rare disease which includes less than 1% percent of all human cancers. The aim of this study is to evaluate the demographic characteristics and risk factors among patients with thyroid malignancy at the Cancer institute and Imam Khomeini hospital in Tehran Iran.
Methods: This is a retrospective descriptive study of the charts of 320 patients admitted with the diagnosis of thyroid malignancy based on pathologic reports in the above- mentioned hospitals from 1992 to 2002.
Results: From the 320 patients diagnosed with thyroid malignancy 68.1% were papillary cancer, 10.9% were follicular cancer, 10.6% were anaplastic cancer, 9.06% were medullary cancer and 1.2% were lymphoma. The average of the patients was 50.2 years, ranging from 12 to 98 years 60.6% were female and 39.4 %were male 22.8% of the patients had histories of thyroid nodule and 5% had received radiation therapy. From the anatomic point of view 57.5% of the cancers were in the right lobe of thyroid, 38.1% were in left lobe and 4.4% in the isthmus. None of the patients had positive family history of thyroid malignancy.
Conclusion: Thyroid malignancy is more prevalent in the fifth decade of life and more common among females. Therefore, among patients in this group, alarming symptoms, such as anterior neck mass, thyroid nodule and voice change, should be evaluated more seriously.

---

Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 !mso]> ject classid="clsid:38481807-CA0E-42D2-BF39-B33AF135CC4D" id=ieooui> Background: A high percentage of the patients at ENT or plastic surgery clinics have ENT abnormalities, either congenital or those developing later in life. Some are life threatening, while others cause disability and esthetic problems, with profound consequences for the affected child and the family. In addition, ENT abnormalities usually place stress on interpersonal relationships, causing social isolation, unhappiness and depression. The majority of these abnormalities is genetic and follows autosomal recessive pattern of inheritance. Geneticists believe that there is a higher frequency of autosomal recessive disorders among the offspring of consanguineous parents. The aim of this study was to find the frequency of ENT abnormalities among children born of consanguineous parents.
Methods: We studied 3503 files (pedigrees) of patients referred for genetic counseling at the Department of Genetics at Imam Khomeini Hospital, Tehran, Iran, from 1999 to 2000. We studied these cases according to degree of parental consanguinity, patterns of inheritance and gender using SPSS v.15.
Results: Of all 3503 files, 206 had ENT abnormalities, of which 157 had consangui-neous marriages. Among these 157 pedigrees, 496 cases had consanguineous parents. Out of the 496 cases, the four most frequent ENT abnormalities were: 115 cases (23.2%) of deafness, 53 cases (10.7%) of hearing loss, 12 cases (2.4%) of cleft lip and palate, and 5 cases (1%) of cleft palate.
Conclusion: This high frequency of ENT abnormalities indicates that consanguineous marriage should be discouraged by Iranian policy makers in order to reduce the burden of these disorders on society. Further research into the cultural problems that encourage consanguineous marriage and ways of resolving these problems is recommended.