Showing 8 results for Rohani
S M Rohani ,
Volume 53, Issue 1 (30 1995)
Abstract
Forty-six cases of patients suffering from acne cystica (conglobata) were treated by low-dose dapsone plus folic acid (1 mg/day). This study has been performed on patients that had no response to other treatments. Several essential and careful tests and examinations were performed on patients before and during treatment. Ten patients of 46 above-mentioned cases were excluded from treatment protocol, because of the reasons that have been mentioned in this article. In 33 cases of 36 patients that recieved the treatment, the cystic lesions were disappeared without any exception and had satisfactory response to treatment.
Rohani N, Alipour A,
Volume 58, Issue 2 (7 2000)
Abstract
Ultrasonography is a useful procedure in evaluation of spleen size in different clinical conditions. In this study, we used it to evaluate spleen size in patients with various heptologic, hematologic and autoimmune diseases. To express spleen size, a spleen index (SI), the product of the transverse diameter and its perpendiculr diameter measured on the maximum-sectional image of the spleen, was used. Splenomegaly was present in high percentages of patients with liver, blood, collagen or autoimmune diseases, even though a majority of these spleens were not large enough to palpate. By grading the SI, characteristic distributions of SI were obtained for patients with different types of diseases. Obtaining and grading the SI by the use of ultrasound appears to be a significant supplemental aid for evaluating spleen size, especially in patients whose spleen are not palpable.
Rohani M, Khorshidi A, Moniri R, Torfeh M, Abddoshah F, Saffari M, Shajari Gh R, Moosavi Gh A,
Volume 67, Issue 3 (5 2009)
Abstract
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Background: Tuberculosis is an important cause of death
in some countries. The world health organization estimates that if stronger
measures are not taken up to control the prevalence of this disease, from 2000 to 2020 a billion people will be infected by the
bacterium. According to time consuming of common detection methods of Mycobact-erium
tuberculosis such as culture, it is necessary to evaluate a rapid detection
tests such as PCR. Rapid diagnosis of tuberculosis may have
profound effects in patients' care According to importance of rapid detection
and treatment of tuberculosis and for determine of sensitivity, specificity,
positive predictive value and negative predictive value of PCR by using IS6110 this study was done
in Kashan university of medical science.
Methods: A total of 248
sputum samples from patients suspected of mycobacterial diseases were studied. DNA was extracted by boiling method. IS6110 PCR method by a specific pair of primers designed to amplify 123bp and 245bp sequences of the insertion sequence, 6110, in the M. tuberculosis genome was used to
analyze sputum samples.
Results: 32 out of 248 (12.9%) of samples had positive culture. PCR yielded a sensitivity of 93.8% and
specificity of 99.1% for the diagnosis of TB patients with TB confirmed by culture. There were two out
of 32 (6.3%) PCR-positive cases
among the patients with non-TB disease.
Conclusion: The findings of the present study indicate that
Multiplex PCR
may provide a faster method of detecting tuberculosis, thus enhancing
diagnostic procedures and we conclude that the performance of an IS6110 PCR assay is valuable in the rapid diagnosis of
tuberculosis.
Rohani Zohre , Sanadgol Hooshang , Khajehnasiri Samaneh ,
Volume 69, Issue 12 (5 2012)
Abstract
Background: Atherosclerotic vascular disease is a major cause of morbidity and mortality in patients with end-stage renal diseases on maintenance hemodialysis. Early atherosclerotic changes of the arterial wall can be evaluated by measuring intima-media thickness (IMT), and looking for the presence and structure of plaques and parameters of vascular resistance. In this study we investigated the relationship between carotid IMT and pulsatility index (PI) or resistive index (RI) values in hemodialysis patients.
Methods: Sixty hemodialysis patients (27 females and 33 males median age 41.7 years) and 60 healthy volunteers (32 females and 28 males, median age 37.8 years) underwent ultrasonography of common carotid artery for the determination of IMT, PI and RI.
Results: Bilateral IMT was significantly higher in hemodialysis patients than in control group (P<0.001). Left carotid artery RI and PI were found to be significantly higher in hemodialysis patients than in the controls (P<0.001). Right carotid artery RI and PI had no significant statistical differences between the two groups (P=0.18 and P=0.78, respectively). There was a moderately significant negative correlation between the left carotid IMT and left RI and PI in the controls (r= -0.42, P=0.001 and r=- 0.43, P<0.001, respectively).
Conclusion: PI and RI values of the left coronary artery increased as did IMT in hemodialysis patients. Therefore, measurement of RI and PI values together with IMT are recommended for early diagnosis of atherosclerosis in hemodialysis patient.
Soheyla Rohani , Fatemeh Hajighasemi , Fatemeh Sefid ,
Volume 76, Issue 5 (August 2018)
Abstract
Background: Immunoglobulins are a group of proteins have important role in defense against microorganisms. Human immunoglobulins are divided into five classes: IgA, IgM, IgD, IgE and IgG. Immunoglobulin G (IgG) is the highest abundant antibody in serum and extravascular fluids. The extent of serum IgG is related to severity of several diseases such as infections, so IgG has great diagnostic worth. Accurate measurement of IgG, needs exact and sensitive diagnostic instruments such as human IgG- specific monoclonal antibodies. Moreover, targeting of IgG has been useful in treatment of a number of diseases. According to experimental studies the Fc region of human IgG is highly immunogenic. Immunoinformatic is a division of immunology uses the computational biology for more precise diagnosis of diseases. The aim of this study was determination of conformational epitopes in the fragment of crystallizable (Fc) fragment of human IgG by immunoinformatic.
Methods: The amino acid residues and third structure of reference human IgG were found in protein data bank (PDB). Second IgG structure was defined by Phyre2 software (http://www.sbg.bio.ic.ac.uk/~phyre2/). Conformational epitopes of the Fc fragment in human IgG were specified by ElliPro (http://tools.iedb.org/ellipro/) and DiscoTope (http://www.cbs.dtu.dk/services/DiscoTope) softwares.
Results: In this study two conformational epitopes (one in constant heavy chain 2 (CH2) domain and another one common between CH2 and CH3 domains) sited in Fc fragment of human IgG were determined by ElliPro software. Also, two conformational epitopes (Both common between CH2 and CH3 domains) located to Fc fragment of human IgG were determined by DiscoTope software.
Conclusion: In this study a number of conformational epitopes located to Fc fragment of human IgG were determined by two immunoinformatic softwares (ElliPro and DiscoTope). The epitopes recognized by both softwares were situated in CH2, CH3 or both of these domains in the human IgG heavy chain. Thus, it seems that CH2 and CH3 domains of Fc region in human IgG are highly immunogenic. Moreover, ElliPro and DiscoTope softwares can be useful tools for identification of epitopes located to Fc fragment of human IgG.
Reza Hajati , Mohammad Masoud Rahimi Bidgoli, Mohammad Rohani , Afagh Alavi ,
Volume 78, Issue 2 (May 2020)
Abstract
Neurodegeneration with brain iron accumulation (NBIA) is a rare set of inherited neurodegenerative disorders with abnormal accumulation of iron in basal ganglia. It is a clinically and genetically heterogeneous disorder that is characterized by movement disorders, dystonia, dysarthria, Parkinsonism, intellectual disability, and spasticity. The age at onset varies from childhood to adulthood and the rate of progression is different among affected individuals. Although there is no information about the exact prevalence of NBIA in the world-wide, it is estimated less than 1/1,000,000 in population. NBIAs are inherited in autosomal recessive, autosomal dominant or X-linked fashions. Until now more than 10 genes have been identified for this group of disorders. Among these, only two genes encode proteins that directly involved in iron metabolism. Therefore, how iron contributes to the pathogenesis of NBIA remains unknown. The remaining NBIA-causing genes participate in lipid metabolism, lysosomal functions or autophagy process, and the roles of some of them remain unknown. NBIA is categorized based on the genetic cause of the disease. PKAN, PLAN, MPAN, and BPAN are the most common forms of the disease result from mutations in the PANK2, PLA2G6, C19orf12, and WDR45 genes, respectively. The diagnosis of NBIA is usually based on clinical features and a specific pattern of brain MRI which results from the abnormal accumulation of iron. For example, the pattern of “eye of the tiger” is observed in the brain MRI of PKAN cases. Since, clinical evaluations and neuroimaging have failed in the diagnosis of the disease in some NBIA cases, genetic testing will be helpful. Development of whole-exome sequencing (WES) has facilitated the identification of disease-causing genes but it seems some of NBIA-genes have remained unknown, yet. Identification of novel genes and molecular pathways will enable a deeper understanding of the underlying molecular bases and our knowledge about the pathogenesis of the disease. There is currently no comprehensive study about the NBIA in Iran, however, the latest discovered NBIA gene, GTPBP2, has been identified in an Iranian family.
Mohammad Rohani, Seyed Amirhassan Habibi , Elahe Amini, Omid Aryani, Mahdi Dadfar, Hamzeh Zangeneh,
Volume 80, Issue 11 (February 2023)
Abstract
Background: chorea-acanthocytosis is a form of the autosomal recessive disease. The onset of disease symptoms usually starts from the third decade of life and presents with chorea, other abnormal movements such as eating dystonia, tongue and lip biting, vocal and motor tics, seizure, and behavioral impairment. In this study, the clinical presentations and brain imaging of these patients were reported.
Methods: In this descriptive study, information about patients with a specific movement disorder who were referred to a tertiary center in the Rasool Akram hospital (Tehran) from March 2018 to February 2019 were recorded. The inclusion criteria were the presence of chorea (a form of abnormal movement) and the presents of acanthocyte cells higher than 10% in a peripheral blood smear. The exclusion criteria were the evidence of secondary causes of the chorea or endocrine disorders. The clinical symptoms and brain imaging findings were evaluated by two expert neurologists and recorded in the patient's electronic files.
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Results: Twenty-seven eligible patients were included. 18 patients were male and 9 were female. Sixteen patients had seizures and 90% of them were categorized as generalized tonic-clonic seizures. 21 patients had eating dystonia (71 percent were male and 29 percent were female) and 18 patients had complex motor and vocal tics, 11 patients presented extra ocular movement disorders, and 11 patients had evidence of tongue and lip biting. The absence of the deep tendon reflex was detected in 23 patients. Considering all the patients' movement disorders, the prevalence of eating dystonia was significantly higher in men than in women. (P=0.049). Other abnormal movements were not different between men and female. All patients had caudate atrophy and increased signal intensity in T2/Flair sequences in caudate nuclei and putamen in the brain imaging.
Conclusion: The most common abnormal movement after chorea was eating dystonia. The male gender was more susceptible to present eating dystonia than the female. However, this superiority was not seen in other movement disorders.
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Negar Sahba, Alireza Amani, Mohammadreza Rohani, Rahmatallah Moradzadeh , Azim Forouzan, Mojtaba Ahmadlou,
Volume 81, Issue 1 (April 2023)
Abstract
Background: Improving the quality of life of patients is the main goal of therapeutic interventions in chronic diseases. One way to achieve this is to decrease the severity of symptoms. The aim of this study was to investigate the effect of curcumin capsule on quality of life and symptoms of patients with irritable bowel.
Methods: This clinical trial study was performed on 60 patients with irritable bowel syndrome referred to Amir al-Momenin Hospital in Arak city from April to September 2018, using convenience sampling and Extra-intestinal symptoms severity scale and WHOQOL_BREF tools. The patients were divided into two groups of intervention and control, curcumin capsules were used in the first one, and in the second one, placebo capsules were used twice a day after lunch and dinner for four weeks. All patients were examined at the beginning of the study, the fourth week and three months later, in terms of quality of life, severity and frequency of symptoms and possible complications. During this period, the patients were followed up on a monthly basis through phone calls, and the contact number of the researcher was provided to the patients to call in case of any problems or questions.
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Results: The average age of the curcumin group was 35 years and for the placebo group was 36.43 years. There was no significant difference in the quality of life between the curcumin and placebo groups after the intervention (P>0.05). Significant were found between the curcumin and placebo groups after the intervention (P<0.05).
Conclusion: The results of this study showed that there was a significant difference between curcumin and placebo in improving the clinical symptoms of patients, but the quality of life of patients in both curcumin and placebo groups did not change significantly after the intervention.
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