Showing 5 results for Sharafi
M Farhadi , M Sharafi ,
Volume 55, Issue 3 (30 1997)
Abstract
This is a report of 30 cases of pediatric functional endoscopic sinus surgery (FESS). 28 of these children had chronic sinusitis and 2 had acute sinusitis the most common chief complaints were: 1) Chronic Rhinorea 2) Nasal obstruction 3) Chronic cough. Systemic predisposing conditions were allergy in 7 pts and immotile cilliasyndrome in 2 pts, all of the procedures were performed under general anesthesia. The most common procedures were: 1) Resection of lateral part of the middle turbinate. 2) Antrostomy of the maxillary sinus. 3) Turbinoplasty of the inf turbinate. 4) Anterior erhnoidectomy, (Messerklinger, Approach). There were no kajor complication and only 3 cases of minor complication (2=regeneration of polipoid tissues, 1 synechia) occurred. The duration of follow up was from 6-18 mths recovery occurred in 26 pts. Two of the pts didn't respond because of severe allergy and were referred to immunologist for further therapy 2 others didn't respond appropriately because of immotile cilliasyndrome
Mosayeb Shahriar , Azam Sharafi , Abolfazl Emamdadi , Nezarali Molaie ,
Volume 67, Issue 10 (1-2010)
Abstract
Background: Cough is one of the most common symptoms for which outpatient care is sought. Since, a few research evaluated efficacy and therapeutic effect of baclofen in remedy of cough (especially chronic cough), In this study we compared the efficacy of oral Baclofen 20 mg with Dextromethorphan to improvement of cough in two groups.
Methods: In this double blind randomized clinical trial, 120 patients with chronic cough (up to three weeks) that were referred to respiratory diseases clinic of Ali Ebn-e Abitaleb (AS) hospital in Zahedan, Iran at 2007 were randomly devided to two groups. 60 peoples in each, (baclofen recipient group with mean age 32.32±6.51 and dextromethorphan recipient group with mean age 31.54±5.06 year) were evaluated for qualitative decline of severity, period and duration of cough for 14 days.
Results: In baclofen recipient group 73.3% and in dextromethorphan recipient group 65% all patients had decline of severity, period and duration of the cough. Statistically, there were no significant differences between two groups in regard to qualitative decline of severity, period and duration of cough (p>0.05). Also, there were no drug related side effects in the patients.
Conclusions: Baclofen decreased severity, period and duration of cough more than dextromethorphan. Because there were no significant differences between two groups, we needed to do more quantitative researches to compare them.
Keshavarzi F, Nafissi N, Sirati F, Fallah Ms, Salehi R, Harriry Z, Shahab Movahead Z, Vahidi M, Sharifi Z, Sharafi Farzad M, Zeinali S,
Volume 69, Issue 9 (6 2011)
Abstract
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Background: Breast
cancer is the most common form of hereditary cancer worldwide and is an
important cause of morbidity and mortality. Approximately 5-10% of breast
and ovarian cancers are
due to the highly penetrating germline mutations in cancer predisposing genes. Two genes, BRCA1 and BRCA2, account for
at least half of these cases. The demand for BRCA1 and BRCA2 mutation screening is rapidly
increasing as their identification will affect the medical management of people
at increased risk for the disease. Therefore, the aim of this study was to
investigate BRCA1/2 mutations in 100 high risk Iranian families.
Methods: One hundred families who met the
minimal risk factors for breast/ovarian cancer were screened among
the families referred to Kawsar Human Genetics Research
Center for the diseases in 2009-2011. The entire coding sequences and each
intron/exon boundaries of BRCA1/2 genes were screened for by direct
sequencing and MLPA in both patients and the controls.
Results: In the present study, we could detect
the following novel mutations:
p.Gly1140Ser, p.Ile26Val,
p.Leu1418X, p.Glu23Gln,
p.Leu3X, p.Asn1403His,
p.Asn1403Asp, p.Lys581X,
p.Pro938Arg, p.Thr77Arg,
p.Leu6Val, p.Arg7Cys,
p.Leu15Ile, p.Ser177Thr,
IVS7+83(-TT), IVS8 -70(-CATT),
IVS2+9(G>C), IVS1-20(G>A),
IVS1-8(A>G), p.Met1Ile,
IVS2+24(A>G), IVS5-8 (A>G),
IVS2(35-39)TTcctatGAT,
IVS13+9 G>C in BRCA1
and p.Glu1391Gly, p. Val1852Ile,
IVS6-70(T>G), 1994-1995
(InsA) in BRCA2.
Conclusion: Ten mutations seemed to be pathogenic and the disease-causing
mutations were seen in 16% of the families. In addition, from the
total number of substitutions and reassortments (42), 80% related to BRCA1 and 20% to mutations in BRCA2 genes.
Seyedeh Zohreh Jalali, Sadroddin Mahdipour, Reza Sharafi, Fariborz Torkipour, Afagh Hassanzadeh Rad , Babak Moqtader, Marjaneh Zarkesh ,
Volume 79, Issue 10 (January 2022)
Abstract
Background: one of the leading clinical problems for premature neonates especially with very low birth weight is the type and amount of feeding. The authors aimed to compare outcomes of slow versus rapid feeding in premature neonates hospitalized in Al-Zahra hospital, Rasht.
Methods: This is a clinical trial that was conducted on 62 premature neonates aged less than 35 weeks of gestation who were referred to Al-Zahra Hospital from April 2015 to April 2016. They weighed 1000-2000 gr at birth. Samples were randomly assigned to intervention or control groups. The intervention included neonatal feeding with breast milk or formula with feeding advancement of 30 cc/kg/day which was compared with the routine method of slow feeding (20 cc/kg/day). Neonates were assessed until discharge or the occurrence of Necrotizing enterocolitis. Data were reported by descriptive statistics including mean, standard deviation, frequency, and percent, and analyzed by independent samples t-test and chi-square test in SPSS software, version 22 (IBM SPSS, Armonk, NY, USA).
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Results: All 62 patients finished the study including 31 neonates weighing 1000-2000 gr at birth in the intervention group and 31 neonates weighing 1000-2000 gr at birth in the control group. Neonates in the intervention group reached to full milk feeding of 150 cc/kg/day sooner (6.06±1.34 versus 9.45±2.39), return to birth weight faster (9.89±3.57 versus 12.9±6.46), had a lower duration of needing parenteral fluids (5.10±1.61 versus 8.86±3.81), and had a lower duration of hospitalization (9.97±4.03 versus 16.87±9.13) compared to controls. Results showed that there was no necrotizing enterocolitis in the intervention and control groups.
Conclusion: The results of this study showed that initiating feeding by 30 cc/kg/day method shortened the duration of access to intravenous line and hospitalization and caused sooner discharge. Also, no adverse complication was noted. Therefore, it seems that further investigations assessing these methods can be help manage preterm neonates.
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Erfan Dehghani, Pezhman Bagheri, Zahra Montaseri , Niloofar Sohrabi , Mehdi Sharafi ,
Volume 82, Issue 1 (April 2024)
Abstract
Background: COVID-19 is one of the most recent known human infections that has resulted in a global pandemic, causing high rates of morbidity and mortality worldwide. This study evaluated the clinical and epidemiological characteristics of the waves of the corona epidemic within a university surveillance system in southern Iran.
Methods: This cross-sectional study analyzed data from 24,132 individuals with Covid-19 in the registered waves from the beginning of the Corona epidemic from March 2020 to March 2021 in one of the southern universities of Iran. Information on age, gender, number of infections, severity, hospitalization, recovery rate, dominant strain, and compliance with protocols separately for each wave from 2020 to 2021 was collected from the University's databases. After calculating the cumulative incidence rate, mean and standard deviation and drawing graphs, chi-square, Mann-Whitney and one-way ANOVA were used in SPSS26 at a significance level of 5%.
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Results: The cumulative incidence of the disease was 11.36%, with a relative frequency of hospitalization at 11.7% and an average hospital stay of Seven days. The highest percentage of protocol compliance was applied in the initial waves. The highest frequency of infection was in the third wave, where men were more infected than women in all waves except the 4th and 5th waves. High blood pressure was the most common underlying disease in patients and the most lung involvement was observed in the fifth wave. Most of the patients have recovered, and the highest rate of recovery was observed in the sixth wave. Significant associations were found between hospitalization duration, underlying conditions, and clinical symptoms across different waves (P<0.001). Systemic symptoms were the most common, and there was a notable difference in radiological findings between waves (P<0.001).
Conclusion: The findings of this study emphasize the significant impact of underlying diseases and the severity of clinical symptoms on hospitalization outcomes. They also highlight the need for appropriate evidence-based management strategies and consideration of clinical changes and radiological patterns when evaluating diseases in different groups.
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