Tehran University Medical Journal

Background: Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo and nystagmus in clinics. Vertigo has many causes and the recurrence of vertigo is unknown. Among a lot of factors, vitamin D deficiency is more important. This study was conducted to determine the effect of vitamin D supplementation on torsional nystagmus in BPPV patients. This study wants to show the deficiency of vitamin D leads to the recurrence of BPPV.
Methods: This case-control study was conducted from April 2017 to May 2018. All eligible patients with BPPV were presented to the Audiology clinic of Babol Rouhani hospital consecutively. Diagnosis of BPPV and the presence of nystagmus were confirmed and serum vitamin D was assessed. Dix-halpike maneuver and videonystagmography (VNG) for assessing nystagmus were done and for serologic assessment, ELISA was performed for analyzing the level of hydroxy 25 vitamin D.Vitamin D sufficient patients (more than 20 ng/ml) with BPPV were considered as the control group and vitamin D deficient patients (less than 20 ng/ml) were as the test group.
  In all the patients of two groups, torsional nystagmus (vertical, horizontal and oblique) were studied and compared.

Background: Nuclear medicine imaging has shown high accuracy in evaluating the metabolism of colon cancer lesions. The aim of this study was to investigate the ability of radiomics features extracted from nuclear medicine images as non-invasive biomarkers of lesion metabolism in patients with colon cancer by examining the correlation of these features with SUV (standardized uptake value) max values.
Methods: The current study was a cross-sectional study that was conducted from July 2022 to July 2023 in the nuclear medicine department of Tehran University of Medical Sciences. In this study, PET/CT (positron emission tomography/computed tomography) images of 60 patients with primary colon cancer were used. Colon cancer lesions were manually delineated on PET images by an experienced physician and saved as VOIs (volumes of interest). Thirty-two textural radiomics features were extracted from each VOI, including feature groups of gray-level co-occurrence matrix (GLCM), gray-level run-length matrix (GLRLM), neighborhood grey-level difference matrix (NGLDM), and gray-level zone length matrix (GLZLM). Then, the correlation of these features with SUVmax values was investigated using the Spearman correlation coefficient statistical test. Also, the value of p<0.05 was considered as the significance level of the test.
Results: A comprehensive analysis revealed that more than 96% of the examined radiomics features specifically, 31 out of 32 exhibited a statistically significant correlation with lesion metabolism values, as indicated by p-values less than 0.05. Among these features, GLZLM_HGZE stood out with a high correlation coefficient of 0.9881, alongside a significance level of less than 0.0001. Similarly, GLZLM_SZHGE also demonstrated a strong correlation, with a coefficient of 0.9723 and a significance level below 0.0001, indicating a robust relationship with SUVmax values. In contrast, GLZLM_LZHGE was the only feature that failed to show a significant correlation with lesion metabolism values (p>0.05).
Conclusion: The radiomics method has the potential to be used as a completely non-invasive method to evaluate the metabolism of colon cancer lesions and facilitate the monitoring and treatment of patients with colon cancer.