Tehran University Medical Journal

---

In this research, the effects of heroin in the placenta of addicted mouse were studied properly.
Methods and Materials: For this reason we used of addicted female mice before, during and after gestation and also a control group of healthy mice. The male mice were in two groups of addicted and healthy. Heroin were used in concentration of 0.1, 0.3 and 0.5 mg/ml in tap water. Placenta of mice separated from uterus in 17th days of gestation and compared with placenta of non addicted mice, with diameter, weight and abnormal conformations.
Results: The results showed that there were significant comparison between diameters and weights of these two groups (p<0.0001). In morphological studies, there were changes in size (small placenta, giant placenta), joining and hemorhagic state placentas.
Conclusion: According to the results we concluded that the opioids even with with very small doses can induce harmful effects on gestation and non-pure heroin in Iranian smugglery is much more harmful than the pure one.

---

Morphine is the most important alkaloid of opium family which is found as much as ten percent in opium, and is in two types the sulfate morphine and the hydrochloride morphine.
Materials and Methods: In this study morphological changes of uterus of surri mice due to oral consumption of sulfate morphine were studied. It was shown that, female surri mice following gradually increasing of morphine to water (0.1 and 0.01) mg/ml were depended to morphine. Female surri mice were classified in two age groups before puberty and depended to morphine during puberty. Each age group took morphine for 21 days. After finishing the period, the mice anesthetizing were weighted, then were anesthetizing and uterus was studied the length, width and apparent features.
Results&ConcIusion: In this study it was distinguished that length and width of uterine horn, between experimental and control groups, were significant (P< 0.01). Morphological changes such as anemia, the thinness and fragitidily walls of uterus and filiformity of uterine horns were observed.