Showing 8 results for Vaez
K Imandel , I Mobedi , A Mesdaghinia , F Vaezi ,
Volume 56, Issue 2 (30 1998)
Abstract
Wastewaters are one of the most important sources for transmission of pathogenic agents in environment, so they should be disinfected in a manner that their overall qualities become accordant with WHO-guidelines, if it is needed to reus water correctly. Unfortunately, the protozoa and parasitic worm's eggs can not be destroyed by chlorination alone. This experiment was carried out in order to determine the efficiency of the UV-Lamps in inactivation of the Ascaris Lumbericoides-ova which is the most resultant organism among the other nematode eggs. The minimum inhibitory dose of UVR (UVC plus UVB irradiances) for Ascaris-ova complete destruction ascertained to be 420 miliwatts-seconds per square centimeter.
Vaezi Gh, Zarrindast M R, Salarian Zadeh A, Babapour S,
Volume 65, Issue 7 (4 2007)
Abstract
Background: Anxiety is a complex phenomenon with important results. In fact anxiety is a biologic process that has repetitive biological and physiological effect on the biological structure of brine. From long time ago anxiety and fear has bean one of the important psychological issues and for the control of anxiety different drugs with different mechanisms have been presented and understanding mechanisms that are involved lead us to newer drugs discovery. In this research the effect of morphine on the anxiety in the adult Male rats in the Ventral Tegmental area (VTA) and Nucleus Accumbens (NAc) was studied.
Methods: The elevated plus maze was used in combination with the percentage of time spent in the open arms of the maze (OAT %) and the percentage of entries into the open arms (OAE %) to measure anxiety. Increases in the OAT% and OAE% indicate an anxiolytic effect (reduction in anxiety), whereas decreases in the OAE% and OAT% indicate an anxiogenic effect. Adult male rats, weighing 200-240 grams, underwent surgery. After five days, the rats were injected with saline and three different doses of morphine (2.5, 5, and 7.5 µl/rat). Experiment one included the injections into the VTA. In the second experiment, these injections were in the NAc. Behavioral tests were conducted between 12 pm and 4 pm and each animal was used once for each experiment.
Results: In the first experiment, although these doses of morphine injected into the TVA had no effect on the OAE%, a dose of 5µl/rat increased the OAT%, showing a decrease in the animals' anxiety. In the second experiment, doses of 2.5µl/rat injected into the NAc induced a significant increase in the OAT% and OAE%, there by displaying decreased anxiety in the animal. However, no significant change in the activity of the animals was observed.
Conclusion: As a Result of these experiments, it seems that different doses of morphine can decrease anxiety, probably through interaction with gabaergic system. |
Shabanloei R, Ahmadi F, Vaez Gharamaleki J, Hajizadeh E, Javadzadeh Y,
Volume 65, Issue 9 (3 2007)
Abstract
Background: Stomatitis, the inflammation of the mucous lining of any of the oral structures, is a frequent side-effect of anticancer drugs due to excess uric acid production. Strict oral hygiene and the application of an appropriate mouthwash has been reported to relieve pain and improve patient quality of life. Allopurinol is a drug used to treat conditions caused by excess uric acid. The aim of this study to evaluate the effectiveness of prophylactic use of allopurinol mouthwash for stomatitis in patients undergoing chemotherapy.
Methods: In this quasi-experimental study, 42 patients were randomly assigned to either a study group or a control group. In the study group (28 patients), patients used 5 mg/ml allopurinol mouthwash in hydroxyl propyl methyl cellulose. The control group (14 patients) used water instead of the mouthwash. Treatment was administered for 16 days.
Results: Data collected during the daily follow-up of the patients' oral mucosa showed that allopurinol mouthwash decreased the severity, pain and duration of stomatitis.
Conclusion: Preventing stomatitis in patients receiving chemotherapy improves the health of the patient and compliance with treatment. Based on our findings, allopurinol mouthwash should be used for all chemotherapy patients for the prevention of stomatitis. This nursing intervention can also improve the patient's nutritional state and level of satisfaction.
Sabzehkhah S, Vaezi Gh H, Bakhtiarian A, Salarian A, Zare Haghighi M,
Volume 67, Issue 8 (6 2009)
Abstract
Background: Dopaminergic is the most important
neurotransmitter is fear. The dopaminergic mesolimbic pathway has essential
role in excitable behavior, and it's role in Parkinson disease. The aim of this
research in study, the effect of dopaminergic pathway in fear response.
Methods: The elevated plus maze was used in
combination with the percentage of time spent in the open arms of the maze (OAT%) and the percentage of entries into the
open arms (OAE%) to measure fear. Increases in the OAT% and OAE% indicate an anxiolytic effect
(reduction in anxiety), whereas decreases in the OAE% and OAT% indicate an anxiogenic effect. After
five days, the rats were injected with saline and different doses of sulpiride
and Bromocriptine.
Results: Results showed that intracerebroventricular
administration of sulpiride, in the doses of 5, 20μg/rat and bromocriptine, D2 agonist in doses 65, 95μg/rat produced
a significant effect comparing to sham groups (p<0.05). While intracerebroventricular
administration of sulpiride 15, 10μg/rat,
and bromocriptine 70,
80μg/rat,
did not show any significant effect comparing with sham group (p<0.05). In the current research
intracerebroventricular administration of sulpiride, D2 antagonist at the doses of 5, 10, 15, 20μg/rat and Bromocriptine, D2 agonist in the doses of 65, 70, 80, 95μg/rat were used and theire effect on
the fear behavior were studied.
Conclusions: The possible effect of Dopaminergic
system in the fear process, especially D2 receptor increase fear.
Zohreh Sanaat, Mahtab Rezazadeh, Jalil Vaez Gharamaleki, Jamal Eivazi Ziae, Ali Esfahani, Morteza Ghojazadeh,
Volume 67, Issue 12 (6 2010)
Abstract
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Background: Multiple myeloma is a plasma cell dyscrasia
characterized by proliferation of plasma cells in bone marrow associated with
the production of monoclonal immunoglobulins. In
recent years, the use of arsenic trioxide, formerly approved for treatment of
acute promyelocytic leukemia has been considered for refractory myeloma
treatment. This study was
designed and carried out to evaluate the efficacy and possible side effects of ATO
on patients with refractory multiple myeloma.
Methods: This study carried out on myeloma patients whose
diseases were at least refractory to two standard treatment regimens conducted
in Ghazi Tabatabaei
Hospital in Tabriz-
Iran. Arsenic
trioxide was administered as an intravenous infusion at a dose of 0.25
mg/kg/d for 5 d/week during the
first two consecutive weeks of each 4-week
cycle with two week rest. Patients who completed
one 4-weak cycle were evaluated for response to
treatment.
Results: Twelve patients with refractory disease to
conventional treatment regimens received arsenic trioxide. The
response to the treatment assessed based on the amount of serum proteins
electrophoresis of the 10 patients. Stable
disease observed in four patients (33%),
progressive disease in five patients (41.6%),
complete response in one (3.8%) and the
remaning two patients could not be assessed for response (because of increased
liver enzymes after the first week). One
patient completed six cycles. Some adverse events such
as: increase liver enzymes and serum creatinine, neutropenia, pruritus, nausea,
vomiting, lower extremities edema, and noninfectious diarrhea were observed.
Conclusions: The use of arsenic trioxide is promising in treatment of refractory multiple
myeloma.
Morteza Noaparast , Seyyed Faramarrz Karimian , Seyyed Rasul Mirsharifi , Abbas Rabbani , Farnoosh Vaezi ,
Volume 71, Issue 4 (July 2013)
Abstract
Background: The purpose of this study was evaluation of risk factors of peripheral artery disease (PAD) and effective markers on it.
Methods: This descriptive-analytical study was done during 2010-2011 in the surgical units of Khorramabad Shohada Hospital. Fifty patients who had symptoms of PAD undergoing CT angiography and biochemical markers for them were measured. The investigated variables were family history, site of arterial obstruction, underlying diseases, smoking history, physical activity and stress level. A control group was considered for the study. The comparison was made between these two groups.
Results: Aging showed a significant role in prediction of PAD (70% sensitivity and 64% specificity). Homocysteine had the highest sensitivity (80%) in prediction of PAD, compared with other biomarkers. CRP (74% sensitivity) was the best marker that had positive predictive value for PAD. Fasting blood sugar (FBS) showed a significant role in prediction of true positive cases of PAD (72% sensitivity and 74% specificity). HbA1C with 68% sensitivity and 64% specificity and TG with 50% sensitivity and 44% specificity could be considered as factors related with PAD.
Conclusion: The levels of C-Reacative protein, homocysteine, and FBS were correlated with PAD, HbA1C and TG levels were associated with PAD, but lower than the previously named markers. In this study a significant relationship between lipoprotein levels and PAD was also observed. PAD was associated with sex and age.
Sahar Molzemi , Nahid Bolbolhaghighi , Mabobeh Sedighi , Mahbobeh Hadizade Bazaz , Gholam Hassan Vaezi ,
Volume 76, Issue 2 (May 2018)
Abstract
Background: Ritalin has properties similar to amphetamines and is therefore used arbitrarily. The purpose of this study was to investigate the effect of ritalin on liver histology and some liver enzymes in streptozotocin-safe and diabetic rats.
Methods: This experimental study was conducted in September 2012 at Islamic Azad University, Damghan Branch, Iran. In this research, 80 male rats were divided into 8 groups of 10 rats, which included: control group consisting of healthy rats and experimental groups 1, 2 and 3 (healthy+ritalin), which ritalin was taken as daily gavage 2.5 mg/kg, as well as control group (diabetic) and experimental group 4, 5 and 6 (diabetic+ritalin) after 2 months of diabetic ritalin at doses of 2.5 and 5 mg/kg as daily gavages up to 30 days. At the end of the prescribed day, the rats were anesthetized and after sampling from the heart, samples were taken from the liver and samples were delivered to the laboratory.
Results: Significant decrease in albumin levels of experimental groups compared to control group (P<0.05) and significant increase in aspartate transaminase and alanine aminotransferase enzymes in all experimental groups compared to control group was observed. The rat liver tissue study showed that rats that had been exposed to different doses of riatalin for 30 days, had fibrosis around the arteries (2+), moderate to weak fibrosis, and infiltration of inflammatory cells around the arteries. In experimental groups (diabetic+ritalin), hepatocyte columns have no regularity compared to control.
Conclusion: Oral consumption of ritalin caused a disturbance in the balance of liver enzymes and elevated serum albumin levels in healthy and diabetic rats. In the experimental groups (healthy ritalin) and (diabetic+ritalin), the higher the dose of the drug, the increased levels of liver enzymes as compared to the diabetic group. Severe degrees of tissue alteration are observed in the group (diabetic+ritalin). The texture of the tissue in the group (diabetic+ritalin) disappeared and appeared in the texture of the disintegration.
Farzaneh Sheikholeslami , Safoora Gharibzadeh , Gharibzadeh , Nargess Miyandehi , Farzaneh Ahmadnejad , Saeed Godeyri Eslami , Javad Vaez , Ali Moradi ,
Volume 77, Issue 12 (March 2020)
Abstract
Background: Potency evaluation of rabies vaccine is a cheap, fast, high precision and consistent with ethical values is critical, so researchers have modified a variety of methods such as: National Institute of Health (NIH) method, Single Radial Immunodiffusion (SRID) and so on. The purpose of the present study was to replace an in vitro method consistent with medical ethics criteria instead of an in vivo method. By recognizing that the potency of the rabies vaccine depends on the amount of glycoprotein antigen content and the monoclonal antibody detect the correct folding of antigen of the rabies virus, then the glycoprotein content could be represent of vaccine potency.
Methods: In this study, we designed an immune-capture enzyme-linked immunosorbent assay (ELISA) with three antibodies (capture, primary and secondary) to determine the existent amount of viral glycoprotein in different rabies vaccines, and compared the results at the same time with measuring potency of those vaccines using the NIH method. This applied study was conducted from September 2016 to September 2018 at the Research Laboratory of the World Health Organization Collaborating Center for reference and research on rabies at the Pasteur Institute of Iran in Tehran.
Results: The slope of the standard line was calculated to R2=0.98 (P=0.0013). In the humans’ vaccines, the mean lied between 5.554-7.336 (SD=0.0463-0.1039) and the coefficient of variation was 0.778-2.436 (SD=0.0041-0.2724), at the same time in the animals’ vaccines the mean were 2.293-5.993 (SD=0.0041-0.2724) and the coefficient of variation was calculated 0.182-4.546. For animal vaccines the Pearson correlation coefficient is 0.99 and for the human vaccines this coefficient was 0.95. Also, the concordance correlation coefficient for animal vaccines was 0.98 and for human vaccines is 0.95, indicating a moderate to high concordance in both animals and humans vaccines.
Conclusion: The designed Immuno-capture ELISA kit had a proper acceptance criterion, intermediate precision, good linearity and robustness for measuring the glycoprotein level of the vaccine, which was directly related to the vaccine potency.
