Showing 5 results for Vaezi
K Imandel , I Mobedi , A Mesdaghinia , F Vaezi ,
Volume 56, Issue 2 (30 1998)
Abstract
Wastewaters are one of the most important sources for transmission of pathogenic agents in environment, so they should be disinfected in a manner that their overall qualities become accordant with WHO-guidelines, if it is needed to reus water correctly. Unfortunately, the protozoa and parasitic worm's eggs can not be destroyed by chlorination alone. This experiment was carried out in order to determine the efficiency of the UV-Lamps in inactivation of the Ascaris Lumbericoides-ova which is the most resultant organism among the other nematode eggs. The minimum inhibitory dose of UVR (UVC plus UVB irradiances) for Ascaris-ova complete destruction ascertained to be 420 miliwatts-seconds per square centimeter.
Vaezi Gh, Zarrindast M R, Salarian Zadeh A, Babapour S,
Volume 65, Issue 7 (4 2007)
Abstract
Background: Anxiety is a complex phenomenon with important results. In fact anxiety is a biologic process that has repetitive biological and physiological effect on the biological structure of brine. From long time ago anxiety and fear has bean one of the important psychological issues and for the control of anxiety different drugs with different mechanisms have been presented and understanding mechanisms that are involved lead us to newer drugs discovery. In this research the effect of morphine on the anxiety in the adult Male rats in the Ventral Tegmental area (VTA) and Nucleus Accumbens (NAc) was studied.
Methods: The elevated plus maze was used in combination with the percentage of time spent in the open arms of the maze (OAT %) and the percentage of entries into the open arms (OAE %) to measure anxiety. Increases in the OAT% and OAE% indicate an anxiolytic effect (reduction in anxiety), whereas decreases in the OAE% and OAT% indicate an anxiogenic effect. Adult male rats, weighing 200-240 grams, underwent surgery. After five days, the rats were injected with saline and three different doses of morphine (2.5, 5, and 7.5 µl/rat). Experiment one included the injections into the VTA. In the second experiment, these injections were in the NAc. Behavioral tests were conducted between 12 pm and 4 pm and each animal was used once for each experiment.
Results: In the first experiment, although these doses of morphine injected into the TVA had no effect on the OAE%, a dose of 5µl/rat increased the OAT%, showing a decrease in the animals' anxiety. In the second experiment, doses of 2.5µl/rat injected into the NAc induced a significant increase in the OAT% and OAE%, there by displaying decreased anxiety in the animal. However, no significant change in the activity of the animals was observed.
Conclusion: As a Result of these experiments, it seems that different doses of morphine can decrease anxiety, probably through interaction with gabaergic system. |
Sabzehkhah S, Vaezi Gh H, Bakhtiarian A, Salarian A, Zare Haghighi M,
Volume 67, Issue 8 (6 2009)
Abstract
Background: Dopaminergic is the most important
neurotransmitter is fear. The dopaminergic mesolimbic pathway has essential
role in excitable behavior, and it's role in Parkinson disease. The aim of this
research in study, the effect of dopaminergic pathway in fear response.
Methods: The elevated plus maze was used in
combination with the percentage of time spent in the open arms of the maze (OAT%) and the percentage of entries into the
open arms (OAE%) to measure fear. Increases in the OAT% and OAE% indicate an anxiolytic effect
(reduction in anxiety), whereas decreases in the OAE% and OAT% indicate an anxiogenic effect. After
five days, the rats were injected with saline and different doses of sulpiride
and Bromocriptine.
Results: Results showed that intracerebroventricular
administration of sulpiride, in the doses of 5, 20μg/rat and bromocriptine, D2 agonist in doses 65, 95μg/rat produced
a significant effect comparing to sham groups (p<0.05). While intracerebroventricular
administration of sulpiride 15, 10μg/rat,
and bromocriptine 70,
80μg/rat,
did not show any significant effect comparing with sham group (p<0.05). In the current research
intracerebroventricular administration of sulpiride, D2 antagonist at the doses of 5, 10, 15, 20μg/rat and Bromocriptine, D2 agonist in the doses of 65, 70, 80, 95μg/rat were used and theire effect on
the fear behavior were studied.
Conclusions: The possible effect of Dopaminergic
system in the fear process, especially D2 receptor increase fear.
Morteza Noaparast , Seyyed Faramarrz Karimian , Seyyed Rasul Mirsharifi , Abbas Rabbani , Farnoosh Vaezi ,
Volume 71, Issue 4 (July 2013)
Abstract
Background: The purpose of this study was evaluation of risk factors of peripheral artery disease (PAD) and effective markers on it.
Methods: This descriptive-analytical study was done during 2010-2011 in the surgical units of Khorramabad Shohada Hospital. Fifty patients who had symptoms of PAD undergoing CT angiography and biochemical markers for them were measured. The investigated variables were family history, site of arterial obstruction, underlying diseases, smoking history, physical activity and stress level. A control group was considered for the study. The comparison was made between these two groups.
Results: Aging showed a significant role in prediction of PAD (70% sensitivity and 64% specificity). Homocysteine had the highest sensitivity (80%) in prediction of PAD, compared with other biomarkers. CRP (74% sensitivity) was the best marker that had positive predictive value for PAD. Fasting blood sugar (FBS) showed a significant role in prediction of true positive cases of PAD (72% sensitivity and 74% specificity). HbA1C with 68% sensitivity and 64% specificity and TG with 50% sensitivity and 44% specificity could be considered as factors related with PAD.
Conclusion: The levels of C-Reacative protein, homocysteine, and FBS were correlated with PAD, HbA1C and TG levels were associated with PAD, but lower than the previously named markers. In this study a significant relationship between lipoprotein levels and PAD was also observed. PAD was associated with sex and age.
Sahar Molzemi , Nahid Bolbolhaghighi , Mabobeh Sedighi , Mahbobeh Hadizade Bazaz , Gholam Hassan Vaezi ,
Volume 76, Issue 2 (May 2018)
Abstract
Background: Ritalin has properties similar to amphetamines and is therefore used arbitrarily. The purpose of this study was to investigate the effect of ritalin on liver histology and some liver enzymes in streptozotocin-safe and diabetic rats.
Methods: This experimental study was conducted in September 2012 at Islamic Azad University, Damghan Branch, Iran. In this research, 80 male rats were divided into 8 groups of 10 rats, which included: control group consisting of healthy rats and experimental groups 1, 2 and 3 (healthy+ritalin), which ritalin was taken as daily gavage 2.5 mg/kg, as well as control group (diabetic) and experimental group 4, 5 and 6 (diabetic+ritalin) after 2 months of diabetic ritalin at doses of 2.5 and 5 mg/kg as daily gavages up to 30 days. At the end of the prescribed day, the rats were anesthetized and after sampling from the heart, samples were taken from the liver and samples were delivered to the laboratory.
Results: Significant decrease in albumin levels of experimental groups compared to control group (P<0.05) and significant increase in aspartate transaminase and alanine aminotransferase enzymes in all experimental groups compared to control group was observed. The rat liver tissue study showed that rats that had been exposed to different doses of riatalin for 30 days, had fibrosis around the arteries (2+), moderate to weak fibrosis, and infiltration of inflammatory cells around the arteries. In experimental groups (diabetic+ritalin), hepatocyte columns have no regularity compared to control.
Conclusion: Oral consumption of ritalin caused a disturbance in the balance of liver enzymes and elevated serum albumin levels in healthy and diabetic rats. In the experimental groups (healthy ritalin) and (diabetic+ritalin), the higher the dose of the drug, the increased levels of liver enzymes as compared to the diabetic group. Severe degrees of tissue alteration are observed in the group (diabetic+ritalin). The texture of the tissue in the group (diabetic+ritalin) disappeared and appeared in the texture of the disintegration.
