Showing 5 results for Yavari
Mahjoob F, Yavari M, Jahanzad I,
Volume 62, Issue 2 (12 2004)
Abstract
Background: Wilm’s tumor is the most frequent primary renal neoplasma in pediatric age group. Classically it is composed of three histologic parts: Blastemal, Epithelial and stromal. Different factors are implicated as prognostic determinants. Nowadays special attention is paid to proliferation markers for determining the biologic behavior of tumors. In this study we tried to ascertain the proliferative index of 22 cases of Wilm’s tumor in our center who have had rather good follow up (at least two years).
Materials and Methods: After reviewing the H and E slides, we stained sections with PCNA and ki67 and scanned them by image cytomertry. Then the proliferative indices for each histological part was determined.
Results: We resuted that proliferative indices of blastemal and epithelial parts have significant (P< 0.0002) difference (increment) from that of stromal part. Also the patients were divided into those with recurrence (within two ys of primary surgery) and recurrence. The profileration indices of PCNA for those recurring tumors was significantly higher (PCNA= 22.3%) (P= 0.0015).
Conclusion: Finally we concluded that using proliferative markers in Wilm’s tumor is useful as an effective prognostic factor.
Shatizadeh Malekshahi S, Yavarian J, Naseri M, Rezaei F, Mokhtari Azad T,
Volume 68, Issue 9 (6 2010)
Abstract
Background: Respiratory virus infections represent a major public
health problem because of their worldwide occurrence, ease of spread in the
community and considerable morbidity and mortality. They are one of the most
common reasons for hospitalization of children under the age of six. In some
cases, infection with two different viruses increase the severity of disease
which lead to the hospitalization.
Case presentation: Among 202 samples related to children under the age of six
with respiratory infections, two dual infections of Adenovirus with other
respiratory viruses with PCR test were
detected.
Conclusion: Mixed respiratory viral infections are sometimes
associated with severe disease and recognition of coinfection is important. Dual infections of Adenovirus with respiratory syncytial
virus (RSV) and
Swine origin influenza A (H1N1) virus
were demonstrated. The evidence showed that the co-infection of Adenovirus with
swine origin influenza A (H1N1), has
increased the severity of disease which lead to the hospitalization.
Jila Yavarian , Nazanin Zahra Shafiei Jandaghi, Farhad Rezeai , Talat Mokhtari Azad,
Volume 72, Issue 1 (April 2014)
Abstract
Background: Influenza viruses are one of the most important etiological agents of res-piratory disease in humans and cause epidemics and pandemics with substantial mor-bidity and mortality worldwide. Vaccination and antiviral treatments are the sole and essential way for the prevention and control of influenza infection. During an influenza epidemic before the production of effective vaccine, antiviral treatments are the first step for the prevention and treatment of influenza infection. Adamantanes and neuraminidase inhibitors are influenza antiviral drugs. Because of the increase of drug resistant viruses, the aim of this study was the evaluation of the antiviral drug resistance in influenza A/H3N2 viruses from 2005-2013 in Iran.
Methods: In this study 50 influenza A/H3N2 viruses isolated in cell culture were tested. All samples were subjected to M and NA gene sequencing at the National Influenza Center, School of Public Health, Tehran University of Medical Sciences. RNA was ex-tracted from 200 µl of cell culture supernatants using the Roche high pure viral nucleic acid kit. RT-PCR with the Qiagen one step RT-PCR kit was done. The expected size of the PCR products were analyzed by electrophoresis using 1% agarose gels. The PCR products were sequenced for finding the drug resistant mutants.
Results: All influenza A/H3N2 viruses except four viruses circulating during 2005-2006 had Ser31Asn mutation at M2 channel protein. In the analysis of neuraminidase gene none of the A/H3N2 viruses had K292R, E119V and N294S mutations responsible for drug resistant strains.
Conclusion: This study showed circulating A/H3N2 viruses was resistant to adaman-tanes but susceptible to neuraminidase inhibitors. The national data analyzed in this re-search may help increase knowledge about influenza virus antiviral drug resistance, which is a global public health concern. The authors suggested continuing this study and also the investigation of antiviral drug resistance of influenza A/H1N1 and B viruses.
Farid Suleimani Mohammadi , Abbas Rahimi Foroushani , Mohsen Rokni , Mohammad Farahmand , Kazem Ahmadi Kia , Azadeh Shadab , Hamidreza Ahmadkhaniha, Jila Yavarian ,
Volume 74, Issue 11 (February 2017)
Abstract
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Background: Schizophrenia (SC) and bipolar disorder (BD) are two chronic psychiatric illnesses with worldwide distribution. People could be involved at any age, particularly in early adolescence. Main symptoms of SC are non- affective symptoms such as auditory hallucination and illogical thinking. In contrast, BD represents affective symptoms such as depression and mania. Although the main cause of these mood disorders has been remained elusive, there are some potential contributing factors that could be considered in the pathogenesis of mentioned illnesses including, genetic and environmental factors. Cytomegalovirus (CMV) is one of the probable contributing factors in SC and BD. CMV is a prototype of herpesviridae family which may infect different cell types such as endothelial and differentiated hematopoietic cells. CMV infections in immunocompromised patients as well as congenitally infected children represent CNS complication such as microcephaly and hearing loss. This virus has capability to impair the limbic structures in brain.
Methods: This descriptive study was designed to evaluate the role of CMV in these illnesses. We investigated the level of serum IgG antibody and the presence of CMV DNA in serum and peripheral blood mononuclear cells (PBMCs) samples of 46 SC and BD patients admitted to Iran Psychiatry Hospital Tehran, Iran from 2014 to 2015 as well as 46 healthy control groups at Tehran University of Medical Sciences. First, the level of CMV IgG antibody was evaluated in serum samples, by enzyme-linked immunosorbent assay (ELISA). Then, DNA extraction conducted by using the high pure viral nucleic acid kit (Roche, Germany). Serologically positive sera along with PBMC samples were tested by Real-time PCR, to investigate the presence of CMV DNA.
Results: Results indicated higher levels of CMV IgG antibody in psychiatric patients, compared with a healthy control group. Afterward, we did not observe the presence of CMV DNA in either case or control groups.
Conclusion: According to the CNS impairment mediated by CMV infection, this virus has been supposed to play an important role in pathogenesis of mental disorders such as SC and BD. We suggest further investigation to be conducted, particularly on other samples such as cerebrospinal fluid.
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Ali Yavari, Hojjat Molaie, Hesam Amini ,
Volume 82, Issue 9 (December 2024)
Abstract
Background: Macromastia can have a significant impact on patients’ quality of life by causing physical discomfort and psychological distress. Reduction mammoplasty can provide both aesthetic and therapeutic benefits. In cases of gigantomastia, where extreme breast hypertrophy prevents the use of traditional pedicled techniques, breast amputation with a free nipple graft is always a considered surgical option. There are different presented methods and designs for this procedure. This surgery is highly beneficial for patients, and most of them report significant improvements in their quality of life and overall satisfaction with the final results.
Case Presentation: In this study, we employed reduction mammoplasty and a free nipple graft with a vertical design and superior pedicle preservation in patients with gigantomastia who were referred to Tehran Imam Khomeini Hospital Clinic during a period of five years (February 2020–February 2025). The patients were out of the range of fertility and were in the range of obesity (most of them had a BMI of over 35(kg/m2)). Then, patient satisfaction and quality of life improvement were evaluated with a standard questionnaire. Finally, complications during and after surgery were recorded. The surgery was performed on 17 patients. The distance from the sternal notch to the nipple was more than 40 cm, and the distance from the nipple to the inframammary fold (IMF) was more than 20 cm in all patients (confirming gigantomastia). Therefore, they were not candidates for pedicled mammoplasty. All the patients were satisfied with the results. Their quality of life, posture, back pain, neck pain, and other symptoms improved significantly. We recorded no cardiovascular complications during or after surgery.
Conclusion: Breast amputation with a free nipple graft is an efficient method for treating gigantomastia and is very safe for patients with diabetes mellitus, cardiovascular diseases, high BMI, and those at infertile ages. A vertical design with superior pedicle preservation can provide both aesthetic and therapeutic benefits, leading to high patient satisfaction and improved quality of life.
