Alavi Aa, Zargari K, Rahim Mb, Bannazadeh M,
Volume 67, Issue 4 (6 2009)
Abstract
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Background: Pulmonary resection is one of the most common thoracic surgeries Bronchial
stump closure is important topic and still is controversy Bronchial stump
closure with stapler is a new method that in addition to rapidity, lowering
separation and dehiscence of suture line and lowering contamination of the
operative site with bronchial secretions, and lowering the main complication
after pulmonary resections which is sustained air leak- main factor in delaying
discharge and patients dissatisfaction.
Methods: Two groups of 16 patients in a
randomized clinical trial compared. In one group bronchial stump closed with
stapler and the other stump closed with hand sewn method. Bronchial closing
time, Operative time, time of airleak, time of chest tube, time of discharge
and complication recorded and compared.
Results: In the stapler group time of bronchial closing was significantly shorter.
Operative time was not different. time of air leak was not statistically
different. No patients with long airleak, and the number of patients without
airleak was greater. In the stapler group, time of having chest tube was statistically
shorter and time of discharge in stapler group was shorter than hand sewn group.
Conclusions: Bronchial
closing with stapler in pulmonary resection is a safe method and in addition to
rapidity, time of chest tube and time of discharge was shorter. Although Time
of air leak was not statistically different but patients in stapler groups had
less Days with air leak and long air leak was zero in this group.
Malihea Khaleghian , Issa Jahanzad , Abbas Shakoori , Neda Zargari, Maryam Mohamadi , Cyrus Azimi ,
Volume 73, Issue 4 (July 2015)
Abstract
Background: The incidence rate of gastric cancer in Western countries has shown a remarkable decline in recent years although it is still the almost common cancer between men in Iran. The proto-oncogene MYC, located at 8q24.1, regulates almost 15% of human genes and is activated in 20% of all tumors. MYC amplification and overexpression of its protein product are observed in 15-30% of gastric neoplasia. The objective of this study was to find the preference of CISH or IHC in the diagnosis and prognosis of gastric cancer.
Methods: In this cross-sectional investigation, 102 paraffin blocks samples of Iranian patients with gastric cancers were studied. All the patients had undergone primary surgical resection at the Cancer Institute Hospital, Tehran University of Medical Sciences from 1987 to 1993. CISH and IHC techniques were applied to the samples. CISH was carried out on 3-µm-thick tissue sections and with a ZytoDot CISH Implementation Kit (ZytoVision GmbH, Germany). IHC was down using the HRP method with the monoclonal antibody. A universal peroxidase-conjugated secondary antibody kit was used for the detection system. All samples were gastric adenocarcinoma and were selected randomly.
Results: Our data revealed that both diffuse and intestinal types of gastric cancer occurred significantly in men more than women. Our results showed an indication of some correlation between grades and CISH results, although the difference was not significant. Our data also showed that CISH+ patients (43.1%) were more frequent in comparison with IHC+ patients (14.7%). There was a correlation between CISH and IHC. This result revealed that there was a significant difference between grades and IHC. There was also no statistically significant difference between CISH amplification in diffuse and intestinal types.
Conclusion: Our conclusion is that for the treatment, management of stomach cancer, and monitoring of progress and prognosis of the tumor that is almost important for patients and clinicians, CISH test is a better and feasible to IHC test, with regards to sensitivity and specificity.
