Showing 38 results for Lip
F Akbari Asbagh ,
Volume 56, Issue 4 (7-1998)
Abstract
Two hundred charts of infertile patients who admitted from April 1995 until March 1996 at Mirza Koucha Kkhan Hospital, retrospectively were reviewed. In this study, the results of hysterosalpingograms and laparascopy of all patients were evaluated. The goal of this study was: whether polypoid alterations and endometrial hypertrophy were a cornerstone sign for endometriosis. Among 32 patients who showed endometrial hypertrophy or polypoid hypertrophy only 3 has had endometriosis in laparascopy which were proved by histopathology, while 22 out of 168 with normal hysterosalpingograms revealed endometriosis. In conclusions: hypertrophic alternations and polypoid changes of endometrium could not be a good sign for endometriosis, and normal hysterosalpingograms do not rule out the endometriosis.
Dabiran S, Maghsoodloo M, Nabaei B,
Volume 60, Issue 4 (7-2002)
Abstract
Introduction: For the time being we have considered that the myocardial infarction is an increasing event in Islamic Republic of Iran and there are many procedures and methods which can help us to diminish the number of death from this ongoing event. The main aim of this research is to determine the survival rate in those patients who have had acute myocardial infarction and the association of it with different variables.
Methods and Materials: The present research is a descriptive case-series study which evaluates the 100 cases of acute myocardial infarction who had been admitted in Tehran Emam Khomeini Hospital during the year 1999.
Results: The mean age of patients was 57 years. The peak of attack rates was in spring and autumn. Investigating of the past history of these patients reviled that 41 percent had been smokers, 63.5 percent have had the history of previous ischemic heart disease, 41 percent have had hyper cholestrolemia, 34 percent had hypertension, 18 percent had diabetes mellitus, 9 percent had mitral rigurgitation and 9 percent had heart block. The Survival rate in our study has been calculated 68 percent in first 28 days of disease.
Conclusion: In our study we concluded that there is significant correlation between survival rate and past history of hypertension, ischemic heart disease, tobacco smoking and clip classification.
Mahmoodi M J, Gharooni M, Moradmand S, Rezaei N,
Volume 60, Issue 5 (8-2002)
Abstract
Myocardial infarction sequel of coronary artery diseases, can be sometimes asymptomatic, called silent myocardial infarction. Some risk factors predispose the patients to this condition. In this study, we intend to determine the predisposing factors in such patients.
Methods and Materials: We included those patients with electrocardiogram changes, consistent with myocardial infarction, who had not any symptoms of ischemia or a previous history of coronary artery disease, consulted for preoperative work up of eye surgery during the year 2000.
Results: We analyzed 100 patients with the diagnosis of silent myocardial infarction. (59 males and 41 females). Among our patients. 99 percent were above age 50 years of age. Their mean age at the time of study was 69.7 years. 78 percent of patients were illiterate. In 41 of them body mass index was above the normal limits (overweight and obese). Their past medical history revealed that 46 patients had hypertension, 38 patients had hyper-lipidemia. and 26 patients had diabetes mellitus. Also, a positive family history of coronary artery disease was seen in 52 percent of the patients. The rate of cigarette smokers and opium addicts, among our patients, was 33 and 13 percents. respectively. Analysis of electrocardiogram changes, showed that 43 patients had inferior myocardial infarction, 24 had antero-septal. and 17 of them suffered from anterior myocardial infarction.
Conclusion: Almost all of our patients with silent myocardial infarction were in old age group. Diabetes mellitus, hypertension, overweight, hyper-lipidemia, and a positive family history of coronary artery disease were the most important predisposing factors, found in such patients, thus taking into account these predisposing factors and control of them would dramatically reduce the prevalence of morbidity and mortality of silent myocardial infarction.
Sharifi A M, Heshmatian B, Karimiam S M, Akbarloo N,
Volume 61, Issue 3 (6-2003)
Abstract
Essential hypertension is one of the risk factors of cardiovascular diseases. Hypertension etiology is not completely known, it seems that rennin-Angiotensin system has an important role in its etiology, Thus better recognition of this system and its activity changes or vascular reaction changes to different parts of this system during progressive hypertension can be more effective in better recognition of the disease progress and treatment.
Materials and Methods: In this study responsiveness of mesenteric vessels of Goldblatt two kidney- one clip (2k-lc) renovascular hypertensive rats to angiotensin / and II with and with out captopril during a time of two , four , six and eight weeks after hypertension induction was investigated and compared with control and surgical sham groups.
Results: This study shows that vascular responsiveness to angiotensin // in animals that passed four weeks of their hypertension , (p< 0.05) and in the sixth and eight week of post induction hypertension (p< 0.01 and p< 0.001) has a significant different with both sham and control groups. Also it has been observed that an increased reaction to angiotensin II with an increased significant rate of arterial hypertension in hypertensive group. In the other hand in spite of inhibition of angiotensin converting enzyme by captopril in animals that have been eight weeks hypertension , on the contrary to other groups reactive to angiotensin /.
Conclusion: Results of this study show that vessels reaction to angiotensin /and II increased due to six to eight weeks post induction renal hypertension. Captopril does not inhibite mesenteric vessels reaction to Angiotensin / in hypertensive Rats after eight weeks. Try to completely inhibit production of angiotensin II maybe a hopful way in controlling essential hypertension.
Miri S R, Kiani A, Mehrabi V,
Volume 61, Issue 6 (9-2003)
Abstract
Ectomesenchimal cells, placed near the embryonal tube, migrate to down and share in facial and cardiac structures. Migration or differentiation disorders of these cell causes cleft lip/ or palate and congenital heart disease (CHD). This item was performed to determine co-appearing of cleft and CHD and to know adjutant factors to that for better management of these patient.
Materials and Methods: Two hundered children with cleft lip and palate were registered. Finding was analyzed by fisher's exact text and chi-square tests.
Results: CHD is ten times of normal population in this research (p< 0.01 and odd ratio 10.39) and incidence of CHD in cleft is high in cleft patient if another congenital animalies were presented (p< 0.001, odd ratio 5.18).
Conclusion: By attention to higher incidence of CHD in cleft patients, it is advised to cardiologist consulting before cleft surgery for better managing.
Matani F, Aminpoor A, Tabibi H,
Volume 64, Issue 7 (8-2006)
Abstract
Background: Cardiovascular diseases are the most important causes of mortality in Iran. Hypercholesterolemia is one of the major risk factors for cardiovascular diseases. Dietary modification such as cereal bran consumption is an approach to reduce this risk factor. The purpose of this present study was to compare the effects of rice bran and wheat bran on serum lipids in hypercholesterolemic women.
Methods: This study was a randomized clinical trial in which 19 women aged 35-65 years with fasting serum total cholesterol 240-300 mg/dl randomly allocated in two groups of wheat bran and rice bran. All subjects recieved 40 g/day bran in addition to their usual diet for 4 weeks.
Anthropometric measurements, dietary assessments by using a 24-hr dietary recall questionnaire and determination of serum lipids were done at the beginning and the end of the study. Data were statistically analyzed by t-test and paired t-test.
Results: There were no significant differences between groups for mean body weight, BMI and dietary confounding factors. During 4 weeks, wheat bran significantly reduced serum total cholesterol and LDL-C by 11% and 21% respectively (P<0.01) but rice bran had no effects on these parameters. No significant changes were found in mean serum triglyceride, HDL-C levels, LDL-C/ HDL-C and total cholesterol/ HDL-C ratios in both groups.
Conclusion: It is concluded that wheat bran have benefical effects on serum total cholesterol and LDL-C levels in hypercholesterolemic women in comparision with rice bran.
Azadbakht L, Mirmiran P, Hedayati M, Esmaillzadeh A, Shiva N, Azizi F,
Volume 64, Issue 10 (10-2006)
Abstract
Background: The NCEP step II diet produced a desirable lipoprotein response in hypercholesterolemia. A relation between plasma concentrations of small dense LDL and cardiovascular risk factors has also been mentioned in children. This study was conducted to determine the effects of the National Cholesterol Education Program (NCEP) step 2 diets on the low density and high density lipoprotein particle size in dyslipidemic adolescents.
Methods: Forty- four dyslipidemic adolescents, aged 10-18 years, participated in this case-control study. The control group was not given a diet prescription and was simply instructed to “eat as usual”. Their eating patterns reflected the consumption of macronutrients, fruit, vegetables and dairy products, typical of what many Tehranian eat. NCEP step 2 diets was a diet with 30% of calories as total fat, less than 7% saturated fat, less than 200 mg cholesterol, less than 15% of calories as monounsaturated fat and less than 10% as polyunsaturated fat per day. Lipoprotein particle size was the major outcome variables, which was measured after 3 months of intervention. Lipoprotein particle size was estimated by nondenaturing polyacrylamide gradient gel electrophoresis using Krauss and Burke methodtion.
Results: The mean body mass index was 26.3±4.2 kg/m2. Baseline characteristics of these adolescents did not differ significantly across the NCEP step 2 and control diet groups. The NCEP diet resulted in higher reduction in total cholesterol (-13±4 vs –2±0.3 mg/dl, p<0.001), LDL (-9±2 vs 3±0.6 mg/dl, p<0.01) and higher increase in size of the LDL (1.7±0.4 vs 0.1±0.4 mg/dl, p<0.001). HDL particle size did not change significantly. The prevalence of hypercholesterolemia decreased significantly (p<0.05) in NCEP step 2 group (68% in NCEP step 2 vs 100% in the control group) after 3 months.
Conclusion: NCEP step 2 diet not only reduces the serum LDL concentration of hypercholesterolemic adolescents but also has a favorable effect on the LDL particle size distribution. The related mechanism needs to be studied in future experimental designs.
Nahvi H, Mollaeian M, Kazemian F, Hoseinpoor M, Keiani A, Khatami F, Khorgami Z, Goodarzi M, Ebrahim Soltani A, Ahmadi J,
Volume 65, Issue 6 (9-2007)
Abstract
Background: Oral clefts are among the most common congenital anomalies. Infants with oral clefts often have other associated congenital defects, especially congenital heart defects. The reported incidences and the types of associated malformations and congenital heart defects vary between different studies. The purpose of this study was to assess the incidence of associated congenital heart defects in children with oral clefts.
Methods: All infants with cleft lip and palate referred to the Children's Medical Center and Bahramy the teaching Hospitals of the Tehran University of Medical Sciences from 1991 to 2005 were prospectively enrolled in this study group. All patients were examined and noted by an academic cleft team contain a pediatrician and a pediatric surgeon, and received cardiac consultation and echocardiography by a pediatric cardiologist. non cardiac associated anomalies, still born and patients without echocardiography were excluded from the study. Data including age, gender, exposure to contagions and high risk elements ,consanguinity and familial history of oral cleft, type of oral cleft, results of cardiac consultation and echocardiography and associated cardiac anomalies were cumulated and analyzed by SSPS version 13.5
Results: Among the 284 infants with oral clefts, 162 were male (57%) and 122 were female (43%). Seventy-nine patients (27.8%) had cleft lip, 84 (29.5%) had cleft palate and 121 (42.6%) had both cleft lip and palate. Of all the patients, 21.1% had congenital heart defects. the most common type Of these congenital heart defects(28.3%) was atrial septal defect.
Conclusions: For patients with cleft lip and palate, we recommend preoperative cardiac consultation, careful examination and routine echocardiography for associated cardiac anomalies, as well as appropriate management and prophylactic antibiotic therapy for those with associated congenital heart anomaly.
Owlia M.b, Hekmati-Moghadam S.h, Dehghani Z, Fallah F, Salimzadeh A.,
Volume 65, Issue 11 (2-2008)
Abstract
Background: Major clinical manifestations of antiphospholipid syndrome (APS) in the central nervous system are generally arterial thrombotic events and a number of non-thrombotic neurologic syndromes. Antiphospholipid antibodies (APAs) are one of the important risk factors for cerebrovascular accidents (CVA). The aim of present study was to assess the relationship between APA titers and CVA in this clinically important age group.
Methods: This case-control study was carried out on patients under 50 years old who had CVA (stroke or transient ischemic attack) in Shahid Sadoughi Hospital in Yazd (central Iran) from Dec 2003 until March 2005. In this study, 61 patients with CVA were compared with 68 age- and gender-matched control subjects. Lupus anticoagulant assay results and APA titers were assessed in both groups.
Results: The mean value of IgM APA titers in patients with cerebrovascular accidents was 6.492 MPL (IgM antiphospholipid units) and 1.846 MPL in the control group. The difference between the two groups was significant (p-value: 0.000). In 12 (20%) of the patients with cerebrovascular accidents, IgM titers were higher than 10 MPL, one of whom had an IgM titer higher than 40 MPL. The mean value of IgG titers in the case group was 5.50 GPL (IgG antiphospholipid units) and 3.51 GPL in the control group. The difference between the two groups was significant (p-value: 0.012). Thirteen (21%) patients with cerebrovascular accidents had IgG titers higher than 10 GPL. The difference between the LA assay results was not significant between the two groups (p-value: 0.311).
Conclusion: The present study showed a positive relationship between APL (IgM and IgG) titers and CVA in patients under 50 years old.
Ahmadi F, Naseri R, Lessan Pezeshki M,
Volume 66, Issue 7 (10-2008)
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Background: Cyclosporine
is one of the main immunosuppressors used for renal transplant recipients, and
is given to prevent transplant rejection. Although the drug increases the
survival of patients and grafted organs, it has some side effects independent
of its effect on the immune system that are usually ignored. In this study, we
evaluate the effect of cyclosporine on serum Mg levels and metabolic side
effects in renal graft patients.
Methods: In this study, we followed 157 renal
transplant recipients (62 females and 95 males) who were being treated with cyclosporine at a
private clinic to prevent transplant rejection. The patients were first physically
examined and then blood samples were obtained in order to measure levels of
cyclosporine, Mg, creatinine, fasting blood sugar, lipids, calcium,
phosphorus, and uric acid levels. We then analyzed the data for correlations between
serum Mg
levels, cyclosporine and other metabolic complications.
Results: The mean levels of Mg and
cyclosporine were 196±0.31mg/dl and 371±192 μg/dl, respectively. Hypomagnesemia was detected in 16 patients (10.2%).There was
a significant negative correlation (p<0.05) between levels of Mg and cyclosporine levels (r=-0.53), serum
creatinine (r=-0.61), plasma LDL (r=-0.3), fasting blood sugar (r=-0.60) and uric
acid (r=-0.36), and no correlation (p>0.05) between levels of Mg and calcium (r=0.2), phosphorus (r=-0.01),
triglycerides (r=0.06) and HDL (r=-0.08). Mean levels of cyclosporine, creatinine, LDL, fasting
blood sugar and uric acid in patients with hypomagnesemia were significantly
different from those patients with normal serum Mg levels (p<0.05). There
was no significant difference between the two groups with regard to mean total
cholesterol, HDL, calcium and phosphorus (p>0.05).
Conclusion: According to the results of this and previous studies,
there is a significant correlation between cyclosporine levels and
hypomagnesemia as well as other biomedical complications secondary to
hypomagnesemia. Therefore, we recommend routine serum Mg determination and greater
attention to hypomagnesemic patients to prevent further complications.
Rafiei M, Sadr Bafghi Smh, Nasirian M, Namayandeh Sm, Abdoli Am, Sadr Bafghi Sm,
Volume 66, Issue 7 (10-2008)
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Background: Atherosclerosis and the side effects thereof
are a major cause of mortality and morbidity in diabetic patients. Diabetic
dyslipidemia is defined by a decrease in blood levels of HDL cholesterol and increases
in triglycerides and LDL
cholesterol. Diabetic dyslipidemia is
atherogenic, inducing cardiovascular disease in diabetic patients at a
frequency that is two to three times greater than that of nondiabetics.
Methods: This study analyzes
the data from the first phase of the Yazd Healthy Heart Program, a community
intervention project focused on the prevention of cardiovascular disease. Using
the cluster sampling method, we analyzed data from 2000 subjects from Yazd, Iran,
ranging in age from 20
to 74 years. Clinical and
paraclinical data were recorded by trained health providers using a
questionnaire with over 700
items.
Results: The most frequent
lipid disturbance was TG>150 in 67.1% of the type-II diabetic patients (p<0.000), 54.6% of whom were unaware
of their TG level. The mean lipid
and TG levels are
significantly higher (p<0.000). Furthermore, women as a group have higher mean cholesterol, LDL-C and HDL-C levels than men (p<0.000). Additionally, diabetic patients were more obese than the
nondiabetic population. (p<0.000).
Conclusion: The high prevalence of
diabetes mellitus in Yazd and hypertriglyceride-mia among diabetics in this
city, in addition to the lack of awareness among more than half of these patients
about their illness and diagnosis, indicate an urgent need to immediately
control dyslipidemia in these high-risk patients.
Azimi C, Karimian H,
Volume 67, Issue 11 (2-2010)
Abstract
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Background: Clefts of the lip and palate are one of the
most common congenital birth anomalies. Genetic factors play a great role in
the etiology of them and the high percentage of the consanguineous marriage of
the parents of the affected persons is one of the reasons. These defects not
only make abnormal changes on appearance of the neonate, but also make a lot of
stress and psychological problems for the patients and their families. Study on
the prevalence of clefts, their risk factors and also genetic counseling for
affected persons and their families can be a guideline for general population
and probably reduce these anomalies over the generations.
Methods: Patients referred to
the Department of Genetics, Imam Khomeini Hospital, Tehran, Iran were studied. A
total of 7374 pedigrees of all the
patients admitted to the Department, were studied during 2002-2005 and 99 pedigrees with the
patients with cleft lip± palate or isolated
cleft palate were separated. The total number of cases among these 99 pedigrees was 136. The effects of
consanguineous marriage, positive family history and sex were investigated
among cases.
Results: 70.8% of patients with
syndromic clefts and 58.7% of patients with nonsyndromic CL±P had parents with
consanguineous marriage. In addition 44.4% of patients with nonsyndromic CL±P
had positive family history.
Conclusion: In our population
prevalence of nonsyndromic CL±P was
estimated to be 7 in 1000 (with 95% Confidence Interval was
between 5 & 9) and prevalence of
nonsyndromic CP was about 3.1 in 1000 (with 95% Confidence Interval was
between 1.8
& 4.4).
Consanguineous marriage of parents seems to have a significant role (p=0.02) on prevalence of the
clefts.
Jelodar Gh, Beyzaee M,
Volume 68, Issue 3 (6-2010)
Abstract
Background: High-frequency electromagnetic field (EMF) is generated by differentsources such as radar installations, radio and television transmitters, medical microwave diathermy device and domestic use of microwave ovens. Radiation leakage of microwave oven may be harmful for users. Kids who are residing near their mothers may expose to electromagnetic field. This study was carried out to evaluate the effect of radiation leakage of microwave oven on body weight, cortisol, thyroid hormones and plasma lipid profile.
Methods: Radiation leakage of microwave oven was measured by RF measuring instrument. For this study 20 immature (7±3 days old and 5±1 g weight) mice were selected and randomly divided in two groups, control and test group. Test groups were exposed to 2450 MHZ microwaves produced by microwave oven three times a day, 30 minute each time. After 60 days, body weights of both groups were determined and the blood samples were collected by heart puncture. Serum cortisol and thyroid hormones levels were evaluated using RIA method.
Results: Radiation leakage from oven showed variations from 6.5 to 57.5 mW/cm2. Mean body weight in test group was 29.5% lower than control group. Serum cortisol, T3 and T4 level were significantly higher in test group compare to control group,(17.44±1.78 vs. 9.94±1.21 ng/ml), (1.39±0.15 vs. 0.86±0.09 nmol/L) and (77.80±7.67 vs.54.6±6.2 nmol/L) respectively. Compare to control group serum Triglyceride level increased while HDL decreased significantly in test group (p<0.05).
Conclusion: Microwaves leaked from oven have deleterious effect on body weight, T4
and cortisol level by decreasing weight gain and increasing these hormones.
Toghae M, Namakian F, Gheini Mr, Aloosh M,
Volume 68, Issue 7 (10-2010)
Abstract
Background: Cerebrovascular ischemic accident is the third most common cause of death in community. Management of high-risk patients reduces complications and mortality. Serum lipid profile is one of the most important factors influencing the prognosis.
Methods: In this cross sectional study, 123 (58 female and 65 male) patients with acute ischemic stroke, mean aged 65.1± 11.16 years, were admitted to Sina Hospital between September 2008 and September 2009. The inclusion criteria were age between 40-90 years and ischemic stroke within the anterior or posterior brain blood system. The exclusion criteria were brain tumor or abscess, venous sinus thrombosis, liver disease, renal failure, hypothyroidism or metabolic problems. Serum lipid profile was evaluated during the first 24 hours after stroke and after 12 hours of fasting. Furthermore, the patients' inability was evaluated on the first and fifth day of hospitalization by NIH Stroke Scale (NIHSS).
Results: Patients' total serum cholesterol was 189.93± 51.46 mg/dl and mean total serum triglycerides was 157.72± 72.67 mg/dl. The mean HDL and LDL was 47.70± 14.43 and 105.98± 37 mg/dl, respectively. In the analysis, a significant inverse relationship was found between serum triglyceride levels and fifth day's NIHSS. In addition, age and a history of heart disease had a significant direct relationship with the first day's NIHSS. (p< 0.05)
Conclusion: The study showed a better prognosis in cases with increased plasma triglyceride levels, after cerebral ischemic stroke. Besides, older age and a history of ischemic heart disease were associated with a worse prognosis.
Alizadeh Z, Kordi R, Hossein-Zadeh Attar Mj, Mansournia Ma,
Volume 69, Issue 4 (7-2011)
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Background: Obesity is a major health problem all around the world. On the other hand, few
people, especially women, are physically active to the levels recommended by Healthy
People 2010 web site managed by
the U.S. Department of Health and Human Services. The
objective of this study was to compare the potential effects of intermittent
and continuous exercise programs combined with concurrent calorie restriction
diets on lipid profile and fasting blood sugar in overweight and obese females.
Methods : Forty-five women with a sedentary life style and a BMI
greater than 25 kg/m2,
were randomly assigned to one of the three groups (15
subjects in each group): a) 40
minutes of medium-intensity intermittent exercise (64-76%
of maximal heart rate), 3
bouts per day for 5 days a week, b) a
single bout of a 40-minute continuous
exercise per day for 5 days a week, C)
the non-exercising control group. A self-monitored
calorie restricted diet was recommended to all participants by a dietitian. The
lipid profile, fasting blood sugar and blood pressure of all participants were
assessed at baseline and 12 weeks after the intervention
period.
Results : After the intervention, there were no significant differences among the groups
in terms of lipid profile [cholesterol (P=0.94),
triglyceride (P=0.62)] fasting blood sugar (P=0.054),
systolic blood pressure (P=0.84) or diastolic
blood pressure (P=0.30).
Conclusion: There
seems to be no significant differences between short term continuous and
intermittent aerobic exercise programs in improving lipid profile, fasting
blood sugar or blood pressure both in overweight and obese women.
Pahlavan-Sabbagh Mr, Khatami Smr, Salari-Far M, Boroumand Aa, Davoudi S,
Volume 69, Issue 8 (11-2011)
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Background: Neutrophil
Gelatinase Associated Lipocalin (NGAL) is a new biomarker which can predict acute kidney injury (AKI) in critically ill patients.
Usefulness of NGAL in the early diagnosis of all types of AKI is under question. We
hypothesized NGAL is an early predictive biomarker of contrast-induced nephropathy (CIN).
Methods: In this process evaluation study, we enrolled 122 patients (Mean age 59.7±10.8 years) undergoing elective
angiography/angioplasty with contrast media during April to September 2009. Serial urine samples were
analyzed in a double-blind fashion by NGAL enzyme-linked immunosorbent assay. CIN was defined as a 25% increase in baseline serum creatinine.
Results : The prevalence of CIN was 30.3%. Significant elevations in urinary NGAL concentrations were noted within 12-h and 24-h after the procedure in patients with CIN. NGAL concentrations after 12 hours was 90.62±105.63 vs. 27.6±45.8 ng/ml in patients with and without CIN, respectively P=0.0001, and 79.78±117.7 vs. 30.92±52.84 ng/ml, 24 hours afterwards P=0.002. Some patients had AKI after five days of exposure rather than the second day (P=0.0001). We found using a cut-off point
of 8
ng/ml with a sensitivity, specificity, negative predictive value and area under
the ROC curve
94%, 25%, 91% and
0.75 respectively
are good for the prediction of CIN in 12-h urinary NGAL and a cut-off point of 5.5 ng/ml with respective values of 97%,
24%, 95% and 0.70 for 24-h urinary NGAL.
Conclusion: Urine NGAL may represent a sensitive
early biomarker of acute AKI after angiography/angioplasty. We recommend the routine measurement
of NGAL in
high risk patients receiving contrast agents.
Mortazavi Mj, Motamedi M, Niknam A, Mazoochy H, Espandar R,
Volume 69, Issue 10 (1-2012)
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Background: One
of the difficulties in acetabulum surgery is appropriate exposure of the site
of surgery. Trochanteric flip osteotomy is one of the surgical methods for
superoposterior and posterior acetabulum exposure. However, due to possible
complications some surgeons prefer to avoid this procedure. This study was
undertaken to determine the outcome of surgical treatment of acetabular
fracture using trochanteric flip osteotomy.
Methods : In this prospective cohort study, 14
patients with acetabular fracture who had
been admitted in Imam Khomeini Hospital in Tehran, Iran, during 2003-2006 underwent trochanteric
flip osteotomy. The patients were followed for at least one year post-surgically.
Demographics, radiologic findings, intensity of pain using visual analogue scale
(VAS),
Harris hip score (HHS), force of hip abductors and complications were noted. Data analysis
was performed using SPSS ver. 13.
Results : The mean HHS was 82.5 (55-95). Heterotopic ossification was observed in three patients. There were
no cases of postoperative infection or non::::union::::. Only two patients showed
displacement of osteotomized fragments. Reduction was anatomic in 10 patients. In one patient, the
force of hip abductors was three-fifth. The mean hip pain was 3.4 based on VAS. There were no cases of
femoral head osteonecrosis. With respect to HHS, the final hip status was
excellent and good in four and six patients, respectively. Three patients had
fair and only one patient had poor condition.
Conclusion: It seems that trochanteric
flip osteotomy has much fewer complications in comparison to other methods justifying
its use in such cases.
Khoshnevisan Alireza, Mirkoohi Maryam, Arjipour Mehdi,
Volume 70, Issue 3 (6-2012)
Abstract
Background: Intracranial lipomas are rare benign neoplasms that comprise 1% of all primary brain tumors. Generally, occur in midline structure and usually identified incidentally on CT scans or in autopsies. The incidence of intracranial lipomas is about 0.08 to 0.46% on autopsies. These benign lesions are slow-growing, usually asymptomatic and rarely require surgery.
Case Presentation: We report a 20 years old male who complained of headache since two years ago. On CT examination, a quadrigeminal cistern lipoma without any pressure effect on neural structures demonstrated. His headache remitted with conservative measures. Here, we have a review on the literature and explain CT scan and MRI findings.
Conclusion: According to the literature and present case, it seems that direct surgical excision of tumor is not justified in the majority of cases and symptoms of patients greatly respond to conservative measures and, at most, in cases of hydrocephalus, CSF shunting relieves their symptoms.
Karbasi-Afshar R, Shahmari A, Shafighi N, Saburi A,
Volume 70, Issue 6 (9-2012)
Abstract
Background: Various therapeutic protocols have been recommended for treating dyslipidemia, particularly in patients with coronary artery disease. The purpose of this study was to assess the efficacy of statin use with or without fenofibrate on echocardiographic findings of patients with coronary artery disease and dyslipidemia.
Methods: This clinical trial was conducted on 124 patients with coronary artery disease and dyslipidemia in Baqiyatallah Hospital in Tehran, Iran during 2008 to 2010. The first group of patients (64) received simvastatin (20 mg) and fenofibrate (200 mg) with low lipid diet and exercise while the second group (60) only received simvastatin with low lipid diet and exercise for one year.
Results: The mean age of the participants was 54.3±6.5 years. The first group showed significant changes in lipid profile and left ventricular ejection fraction (LVEF), (P<0.05). Left ventricular diastolic function parameters showed no significant changes in both groups upon 12 months of treatment.
Conclusion: The results of this study show, one-year treatment by simvastatin and fenofibrate can be effective on lipid profiles, and improve LVEF with resultant positive effect on heart function.
Hassanzadeh T, Barkhordari A,
Volume 70, Issue 7 (10-2012)
Abstract
Background: Coronary heart disease (CHD) is a leading cause of death worldwide and hypertriglyceridemia and hypercholesterolemia are major risk factors for the disease. Considering the role of hyperlipidemia as the underlying cause of cardiovascular mortalities and morbidities, and the limited and conflicting results of studies on CETP gene polymorphisms in Iran, we aimed to study -971 G/A polymorphism of cholesterol ester transfer protein gene in patients with primary hyperlipidemia.
Methods: In this case-control study performed in Hamadan University of Medical Sciences (from May 2010 to April 2011), we recruited 200 patients with primary hyperlipidemia (total cholesterol >250 mg/dl and/or triglyceride >200 mg/dl) as the cases and 200 healthy individuals with normal cholesterol and triglyceride as the control group. Gene segments were replicated by polymerase chain reaction (PCR) and -971 G/A polymorphism genotypes were identified by RFLP technique. Subsequently, plasma CETP activity was measured enzymeatically by a kit in a fluorescence spectrometer.
Results: The allele and genotype frequencies were not significantly different (P>0.05) between the two groups (in the control group: AA 24%, GA 47% and GG 28.5% and in the case group: AA 18%, GA 51% and GG 31%). In the case group, homozygous individuals with A alleles (AA genotype) had greater cholesterol and HDL-c concentrations than those with other alleles (GG and GA). In both cases and controls, individuals with AA genotype had lower CETP concentrations.
Conclusion: We conclude that -971 G/A polymorphism in CETP gene promoter can affect lipid profile and alter CETP activity.
