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MicrosoftInternetExplorer4
Background: Neck
lymph node metastasis has the prognostic role in SCC of the tongue and the
importance of the biologic markers in tumor invasion and metastasis has been
stated in the medical literature. The aim of this study was to evaluate the
relationship between two biomarkers, p53 and EGFR (which had the main role in cell proliferation) and
two other biomarkers, CD44 and E-cadherin, in lymph node metastasis.
Methods: In an analytic descriptive study fifty three patients
with SCC (Squamous Cell Carcinoma) of the tongue who underwent the resection of
tumor and dissection of neck lymph nodes were assessed during the year of 2002-2009.
Histological samples from 53 patients were immunohistochemically stained and the
analysis of these markers were performed due to clinicopathological variable
and metastasis of the neck lymph nodes.
Results: The result showed that among the clinicopathological
factors, the relationship between Age (p=0.01), history of having risk factors (p=0.002), clinical
lymphadenopathy (p=0.002), the size of the tumor (p=0.001),
decreasing of CD44 (p=0.02) and lymph node metastasis of
the neck were statistically significant. No significant relationship were found
between sex and other biomarkers including p53, EGFR, E-cadherin.
Conclusion: CD44 is an important
indicator of prognostic markers that can also be used as an indicator of
clinocopathological markers.
