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Background: Detection rate of Ductal Carcinoma
Insitu of the breast (DCIS) have
increased rapidly over the past decade, which is generally attributed to the widespread
use of screening mammography. The aim of this study was to evaluate the prevalence
of ductal carcinoma in situ in patients who had been referred to Tehran
university medical centers.
Methods: In a retrospective study, medical
records of the patients with diagnosis of breast cancer in 3 teaching hospitals of Tehran University of
Medical Sciences (Cancer Institute, Sina and Shariati Hospitals between 1994-2003) were reviewed and records with
ductal carcinoma in situ were selected and analyzed.
Results: Between 2244 medical records of breast cancer 23 patients had DCIS (1.02%). Mean age was 47.3 years just one patient had been detected by screening mammography and
others had clinical symptoms. 48% of patients
had mass with mean size of 3.3cm. All had
undergone open biopsy (four incisional, 19 excisional). Treatment included 65.2% modified radical mastectomy, 30.4% lumpectomy with axillary dissections and 3.8% lumpectomy alone. Nine patients had radiotherapy after
surgery and ten took tamoxifen as hormonal therapy. Two patients (8.6%) in lumpectomy group had
recurrence in follow ups. Median follow up time was 84 months.
Conclusion: This study shows that the Prevalence of early stages of
breast cancer especially ductal carcinoma in situ is extremely low. (DCIS was 1.02 in comparison with 15-30% in western countries).
These findings indicate the need for increasing public information about breast
cancer in Iran and improving screening programs of breast cancer.
