Rafeian M,
Volume 59, Issue 4 (8-2001)
Abstract
Drug interaction may cause sever adverse drug reactions in patients. The high amounts of prescribed medication in hospitalized patients will cause higher incidence of drug interactions. Therefore, the study of drug interactions in hospitalized patients seems to be worth. We have, studied drug interaction in internal and surgical units, in Kashani hospital in Shahrekord. Factors included in this study were: mean of prescribed medications, frequency of drug interactions, correlation between these two parameters, and the most frequent drug interactions. The frequency of drug interactions in different units of hosital, was as follows: 26.4 percent in surgical unit, 30.7 percent in internal unit and 34 percent in cardiac unit. The mean of prescribed medications was as follows: 3.90 in surgical unit, 3.92 in internal unit and 5.86 in cardiac unit. There was a positive correlation between the number of medications and the frequency of drug interactions in prescriptions. Six different drug interactions, occurred frequently. Therefore, it seems if physicians consider these interactions, the percent of drug interactions would be reduced considerably. We also found that most of drug interactions occurred when two or more diseases were managed concurrently. Therefore, it seems, having attention to these cases, would cause drug interactions to be reduced significantly.
Hamidreza Mehryar , Sahil Farakh,
Volume 82, Issue 2 (5-2024)
Abstract
Background: Medicines that are used to prevent and cure disease may affect patients if used incorrectly, and this study was conducted with the aim of evaluating the frequency of drug interactions in patients admitted to the emergency department of Imam Khomeini Hospital in Urmia.
Methods: This study is descriptive-analytical in a cross-sectional way, From March 20, 2020 to September 21, 2020, a census was conducted on patients admitted to the emergency department of Imam Khomeini Hospital in Urmia, who were 1901 people. The data was collected using a checklist that included information (age, sex, type of drug and severity of interference and type of interference). After collecting the data, it was entered into SPSS software, version 18 (IBM SPSS, Armonk, NY, USA) and analyzed with the help of descriptive and analytical statistics.
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Results: In this study, the results showed that out of 1901 studied patients, 1101(57.9) were male and the rest were female 801(42.1), And the average age of the patients was 61.67±17.13 years, and 1160(60.9) patients did not have drug interactions and 724(39.01) had drug interactions, and the most common type of drug interaction was the moderate type, which was present in 75.1% of cases; And the final clinical outcome of the patients was 1088(57.2) discharge, 296(15.5) personal consent discharge and 506(26.6) death. Also, the most common drug interactions were serotide/salbutamol, azithromycin/ondansetron, and aspirin/nitroglycerin, respectively. And there was no significant relationship between the occurrence of drug interactions and the gender of patients (P=0.27) and finally, the average age of patients with drug interactions was 17.7±61.2 years and in patients without drug interactions was 16.7±61.9 years. Conclusion: The overall incidence of drug interactions in the studied patients was equal to 39.01, and the most common drug interactions in patients were of moderate and mild type; and there was no statistically significant relationship between the age of the patients and the gender of the patients and the incidence of drug interactions.
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