Showing 5 results for Esrd
St Esfahani , A Madani , M Tashviqi , N Ataee , P Mohseni ,
Volume 57, Issue 4 (7-1999)
Abstract
Between 1990-97 two hundered children referred to our department with end-stage renal disease (ESRD) for renal replacement therapy. The ages of these children were 1-14 years (mean 8.14). There was no significant difference in incidence of ESRD between two sexes. We evaluated these children for the causes of ESRD. The most common causes were: Pylonephritis and congenital anomalies of urinary tract (35.5%), glomerular diseases (22.5%) and hereditary kidney diseases (13.5%).
A Madani , M Shakiba , N Taei , T Esfehani , P Mohseni ,
Volume 63, Issue 1 (5-2005)
Abstract
Background: Chronic renal failure defines as progressive and irreversible dysfunction of kidneys that could eventually terminated to end stage renal disease (GFR< 10% NL). Because of therapeutic problem and high mortality and morbidity and it &aposs implication quality of life , ESRD is one of the important dilemma of pediatric medicine .
Materials and Methods: In our study 216 patients evaluated .
Results: Male to female ratio was 1.1 . The peak of the presenting age of ESRD was 10 years old (8-12 y). Congenital urological malformation (30%) , glomerulopathies (20%) , hereditary nephropathies (14.3%) , multisystem diseases (7%) and nephrolithiasis (6.2%) are the most common etiologies of ESRD . VUR in 21% and congenital obstructive disease in 8.5% are the etiology of ESRD. In patients with age five years old and lesser common causes of ESRD are congenital urologic malformation and glomerulopathies. In other age groups , urologic malformation is the most common cause of ESRD. In etiologic assessment of two separate 7 years interval , (1988-1993) and (1996-2003) , there was not any significant change in frequency of etiologies but frequency of congenital obstructive uropathy decreased from 10 % to 5.7%. Total amount of VUR (VUR ± Neuropathic bladder) has not any change but frequency of primary reflux nephropathy decreased from 14.2% to 8%. In this study , in 145 patients hemodialysis continued and 28 cases had unsuccessful renal transplant (13.8%) . 7.4 % of patients had successful renal replacement therapy (RRT) and mortality rate was 7.4% . B
Conclusion: Based on that the most common cause of ESRD is all ages in congenital urologic malformations , early diagnosis and appropriate management of these cases are effective in decreasing incidence of ESRD and with respect to few cases of renal transplant and unsuccessful results in 65% of RRT , the approach of this problem should be revised.
M. Khosravi, M. Ghaheryfar, A. Monfared,
Volume 64, Issue 4 (7-2006)
Abstract
Background: The etiology of End Stage Renal Disease (ESRD) in every community differ according to genetic, nutrition, and public health status. ESRD,the terminal stage of chronic renal failure,needs replacement therapy otherwise could lead to death. The aim of the study is to determine the relative frequency of ESRD etiology in hemodialysis patients of Gilan province.
Methods:This descriptive study was performed on 407 patients who were being hemodialysis in all hemodialysis centers of the Gilan province from September 2002 to September 2003. The original data was collected from the medical records of patients.
Results: The most prevalent causes were: hypertension 35.4% unknown etiology 16.2% diabetes melitus 13.8% , glomerulopathies 9.6% , urologic causes 9.1%, cystic kidney diseases 7.6 % other causes 5.9 % congenital 2.5%.
Conclusion: In our study hypertension was the first etiology of ESRD, followed by unknown causes, however nephrology textbooks indicate diabetes melitus as the primary and hypertension as the secondary etiology of ESRD,.
Seifi S, Soleimani A, Lesan Pezeshki M, Einollahi B, Khatami Mr, Mazdeh M.m, Ahmadi F.l, Maziyar S,
Volume 64, Issue 8 (8-2006)
Abstract
Background: Autosomal-dominant polycystic kidney disease (ADPKD), a common hereditary disease, is characterized by the progressive development and enlargement of multiple cysts in both kidneys, and typically resulting in end stage renal disease (ESRD) by the fifth decade of life. Post-transplant diabetes mellitus (PTDM), a common complication after transplantation with an incidence rate of 2.5-20%, is associated with poor graft and patient survival. In few studies, PTDM has been more frequent in ADPKD transplanted patients. In the present study, we investigated whether there is any association between PTDM and ADPKD in our patients.
Methods: In this prospective study, 140 non-diabetic and nonsmoker successfully transplanted patients (27 ADPKD and 113 non ADPKD patients) were enrolled during three years. Both groups were matched for age, sex, body mass index (BMI), duration of renal replacement therapy before transplantation and also immunosuppressive protocols after transplant. Post-transplant diabetes mellitus was defined as Clinical Practice Guidelines advocated by Canadian Diabetes Association. All patients were followed for 12 months.
Results: PTDM occurred in 11.1% of ADPKD patients and in 13.1% of control group which was statistically insignificant (P > 0.05). The development of PTDM in ADPKD group was not related to sex, age, and hypertension, duration of renal replacement therapy before transplantation, BMI and serum creatinine levels (P > 0.05).
Conclusion: Post-transplant diabetes mellitus appears not to be associated with autosomal-dominant polycystic kidney disease as an etiology of end stage renal disease.
Sattarzade Badkoobeh R, Nozari Y, Larti F, Safari S, Ahmadi F, Emami M,
Volume 68, Issue 10 (1-2011)
Abstract
Background: The role of reactive oxygen
species (ROS) in the pathogenesis
of different cardiac diseases has been documented. Recently, effect of
allopurinol in decreasing the production of ROS and
improving cardiovascular pathogenesis has come into scientific interest. Animal
studies have documented the benefit of allopurinol in improving left
ventricular dilatation, hypertrophy and fibrosis, and myocardial contractility
and in the prevention of systemic vasoconstriction. The aim of this study was
to evaluate the effect of allopurinol in improving diastolic dysfunction in ESRD
patients with hyperuricemia.
Methods: This was an interventional study on 28 patients
(19 males and 9 females)
with ESRD and hyperuricemia. At the end of a one-month
course of allopurinol therapy (100 mg daily),
echocardiographic indices of diastolic dysfunction were measured and compared
to the baseline indices.
Results: The mean level of uric acid was 7.5±0.96 mg/dl. The
mean EF before and after the study were %44.28±%9.8
and %44.64±%9.7, (no significant difference),
Respectively. The two indices of IVCT and
A reversal were shown to have significant
improvement after therapy (p=0.028 and 0.012,
respectively). The grading of diastolic dysfunction didn't improve
significantly after treatment with allopurinol.
Conclusion: Significant
improvement in some of studied indices, reproduced only in male subgroup of
patients that might be related to a better response of males to allopurinol,
however, a longer course of treatment may result in more favorable responses.
Better patient selection in terms of "EF"s
with normal distribution and repeating the study in non-dialysis hyperuricemic
patients may result in more accurate information.
