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Showing 6 results for Ferritin
Study of breath-holding spell and its triggering factors in Children’s Hospital Medical Center
Mr Ashrafi ,
Volume 58, Issue 1 (4-2000)
Abstract

To evaluate breath-holding spell (BHS) and its triggering factors, 47 children with BHS admitted to the out patients clinic of Children's hospital medical center, between Sept 1998-June 1999, were included in this prospective study. Diagnosis of BHS was made for cases by medical history, pediatric physical examination, EEG, ECG and lab findings. 4 cases were excluded from study because of paroxysmal epileptic discharges at their EEGs. Of 43 cases having BHS (M:F: 1.15:1), 74.4% were less there 24 months of age (Mean age 18.4 mo). 77% of patients had onset of BHS within 12 months of age. Family history of BHS in first degree relatives were found in 51% of patients. Parent consanguinity were found in 30% of cases. The commonest type of BHS were cyanotic (79.1%). Pallid (11.6%) and mixed (9.3%) were other types. Pain and anger were the commonest triggering factors. 78% of cases were iron deficient and 53% of cases had iron deficiency anemia.


Evaluation of variability of acute phase proteins in hemodialysis patients
Razeghi E, Lessan Pezeshki M, Aazaripour A,
Volume 64, Issue 9 (9-2006)
Abstract
Background: The prognosis of chronic dialysis patients is poor, in part due to the high incidence of cardiovascular disease and malnutrition. It has been recognized that 30-50% of hemodialysis patients have serological evidence of an activated inflammatory response. Chronic inflammation may cause malnutrition and progressive atherosclerotic cardiovascular disease. It would be obvious interest to study prevalence of inflammatory factors particularly CRP as prominent components of inflammatory syndrome in dialysis patients. The objective of this study was to study prevalence of inflammatory factors particularly C-reactive protein (CRP) in hemodialysis patients.
Methods: We studied 125 dialysis patients in a cross sectional study during summer of 2001 in two university hospitals. Serum CRP (agglutination method), albumin (bromocresol green method) and ferritin (ELISA) were measured in all patients.
Results: One hundred and twenty five patients including 53 (44.1%) men and 72 (55.9%) women were enrolled in this study. Fourteen patients (11.2%) had hypoalbuminemia, 81 (64.8%) had high serum ferritin, and 57 subjects (45.6%) were CRP positive.
Conclusion: According to high prevalence of inflammatory factors especially C-reactive protein in dialysis patients, CRP and other inflammatory factors should be screened in this group of patients routinely because of their prognostic importance.
Assessment of iron stores in candidates for coronary angiography
Nozari Y, Nabati M,
Volume 65, Issue 7 (10-2007)
Abstract
Background: Epidemiological studies have suggested an association between higher body iron stores and coronary artery disease. It is believed that inflammation and oxidation are important mechanisms involved in the complex pathological process of atherogenesis. Free radical production is catalyzed and accelerated in the presence of iron. The determination of plasma ferritin levels is a convenient iron balance assessment method. The purpose of this study was to define the correlation of ferritin levels with severity and extent of coronary artery atherosclerosis.
Methods: In this cross-sectional study, 240 consecutive patients underwent previously indicated coronary artery angiography and were divided into two groups according to their angiographic findings: group 1 with 50% stenosis or less in each of the coronary arteries, and group 2 with more than 50% stenosis of the coronary arteries. Blood samples were taken for routine biochemical tests, including evaluation of serum ferritin levels. The severity and extension of coronary artery stenosis was determined by Gensini score.
Results: Group 1 consisted of 120 patients with a mean age of 52  6.8 years, and group 2 had 120 patients with a mean age of 58.1  10.4 years. We found a correlation between serum ferritin level and severity of coronary artery stenosis among men (p=0.02) however, there was no significant difference in serum levels of ferritin between the two groups (63.88 ng/ml vs. 44.26 ng/ml). Furthermore, there was no significant difference in serum ferritin levels of subgroups of patients with major risk factors such as hypertension, hyperlipidemia, hyperglycemia and smoking.
Conclusion: Overall this study cannot confirm a strong correlation of serum ferritin levels with severity of coronary atherosclerosis in our study population. However, in men it could have a role in the promotion and augmentation of coronary atherosclerosis, suggesting that ferritin could be a comparable index in patients with ischemic heart disease. Therefore, further study is necessary to assess etiological relationship between serum ferritin levels and extension of coronary artery stenosis.
Using decision tree to predict serum ferritin level in women with anemia
Parisa Safaee , Rassoul Noorossana , Kamran Heidari , Parya Soleimani ,
Volume 74, Issue 1 (4-2016)
Abstract

Background: Data mining is known as a process of discovering and analysing large amounts of data in order to find meaningful rules and trends. In healthcare, data mining offers numerous opportunities to study the unknown patterns in a data set. These patterns can be used to diagnosis, prognosis and treatment of patients by physicians. The main objective of this study was to predict the level of serum ferritin in women with anemia and to specify the basic predictive factors of iron deficiency anemia using data mining techniques.

Methods: In this research 690 patients and 22 variables have been studied in women population with anemia. These data include 11 laboratories and 11 clinical variables of patients related to the patients who have referred to the laboratory of Imam Hossein and Shohada-E- Haft Tir hospitals from April 2013 to April 2014. Decision tree technique has been used to build the model.

Results: The accuracy of the decision tree with all the variables is 75%. Different combinations of variables were examined in order to determine the best model to predict. Regarding the optimum obtained model of the decision tree, the RBC, MCH, MCHC, gastrointestinal cancer and gastrointestinal ulcer were identified as the most important predictive factors. The results indicate if the values of MCV, MCHC and MCH variables are normal and the value of RBC variable is lower than normal limitation, it is diagnosed that the patient is likely 90% iron deficiency anemia.

Conclusion: Regarding the simplicity and the low cost of the complete blood count examination, the model of decision tree was taken into consideration to diagnose iron deficiency anemia in patients. Also the impact of new factors such as gastrointestinal hemorrhoids, gastrointestinal surgeries, different gastrointestinal diseases and gastrointestinal ulcers are considered in this paper while the previous studies have been limited only to assess laboratory variables. The rules of the decision tree model can improve the process of diagnosing and treatment of the patients with iron deficiency anemia and reduce their costs.


The relationship of serum iron and ferritin levels with mucormycosis infection in diabetic patients having acute COVID-19 during the year 2021 in Kermanshah University of medical sciences
Shayda Barat, Khosro Iranfar, Mahsa Ghanbari,
Volume 81, Issue 10 (1-2024)
Abstract
Background: Mucormycosis is a rare and aggressive opportunistic fungal infection that has grown significantly in recent years. This infection is rarely seen in healthy people. Mucormycosis usually appears as an acute infection with manifestations in the rhino-cerebral, pulmonary and skin areas, and sometimes its manifestations can be seen as a widespread infection. The special importance of mucormycosis is due to its high mortality rate, which leads to death in 75 to 80 percent of cases. The specific susceptibility of some patients to mucormycosis points to the importance of iron absorption in the pathogenesis of mucormycosis, therefore, we decided to investigate the relationship between serum iron and ferritin levels and mucormycosis disease in patients with underlying factors predisposing to COVID-19.
Methods: This study is a case-control type, in which patients with mucormycosis after contracting COVID-19 and also with a history of diabetes mellitus as the case group and patients with COVID-19 and a history of diabetes mellitus are considered as the control group and the serum level of iron and ferritin will be measured and compared in both groups and the outcome of the study will be determined based on the obtained results.The study took place in hospitals of the Kermanshah university of medical sciences in the Kermanshah city from March 2021 to March 2022.
Results: In this study, 38 patients were examined in two groups of patients with mucormycosis along with COVID-19 and diabetes in the case group and patients with  COVID-19 and diabetes in the control group with an average age of 63 years. In this study, there was no significant difference between the average age in the two studied groups. However, a significant difference was observed between serum iron and ferritin levels in two groups.
Conclusion: Hyperferritinemia is considered not only as an indicator of the systemic inflammatory process in the infection of COVID-19, but also indicates an increase in free iron level, which, as a result, contributes to the growth and spread of the fungus (mucormycosis).

The complicated relation of iron homeostasis and helicobacter pylori infection in the pediatric population: a review article
Heshmat Shahi , Fatemeh Kiaee ,
Volume 83, Issue 6 (9-2025)
Abstract
Helicobacter pylori is one of the most common chronic bacterial infections worldwide, with acquisition often occurring in childhood. While its role in the pathology of gastroduodenal diseases in adults is well-established, its impact on the pediatric population presents a unique set of clinical and pathophysiological challenges. This comprehensive review examines the complex and bidirectional relationship between Helicobacter pylori infection and host iron metabolism in pediatric and infant populations. For this review, the PubMed database was utilized for studies published from April 1979 through December 2024. Studies based on English language were included using the MESH terms "Helicobacter pylori," "iron," and "ferritin." According to the inclusion criteria, studies related to H. pylori infection and iron condition in patients under 18 years old were selected. Articles such as review articles, case reports, letters to the editor, and animal or in vitro studies were excluded. The main aim of this study was to illuminate the critical role of iron as an essential micronutrient and factor for both the host and the pathogen, examining the multifaceted mechanisms involved in H. pylori-induced iron homeostasis disruption in children.
The findings indicate a multifaceted relationship: virulent Helicobacter pylori strains are significantly and inversely associated with true body iron stores, leading to Iron deficiency anemia (IDA). However, chronic inflammatory states can paradoxically elevate ferritin levels, masking underlying iron deficiency. Complex interaction between bacterial infection, host inflammatory responses, and iron deficiency is an important factor influencing both the severity of the damage caused by this bacterial infection and its chronicity in the pediatric population. Identification and comprehensive understanding of these complex mechanisms is of great importance for the effective management of iron deficiency anemia in children with H. pylori infection. Considering, increase in the incidence of H. pylori infection in childhood, it is essential that H. pylori infection be evaluation in children with unknown reasons IDA. Finally, screening methods for H. pylori infection in children is recommended, as this could improve long-term health outcomes.

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