Showing 7 results for Homocysteine
Refahi R, Rahbani M, Afrasiabi A, Refahi S,
Volume 63, Issue 4 (7-2005)
Abstract
Background: The aim of the study is to evaluate correlation between hyperhomocysteinemia and oxidative stress with severity of atherosclerosis lesions.
Materials and Methods: The patients (52 males and 36 females) were selected from individuals with angiographically defined CAD admitted to the shahid Madani Hospital. Control groups were selected from sex and age matched apparently healthy individuals (15 Males and 24 Females). Serum Homocysteine levles were measured by ELISA method (Awareness stat fax-2100 Model). Total antionxidant capacity of samples was determined by Autoanalyzer (COBAS MIRA plus model) using Randox kits. The correlation between the measured parameters and extension of atherosclerotic lesions were calculated using statistical analysis in the both groups.
Results: The mean levels of Homocysteine in patients and control groups were 20.38 ± 10.22 μmol/l and 18.56 ± 9.47 μmol/L respectively and the differences were not significant (p> 0.05) . In the patient group the mean level of Antioxidant capacity was 1.34 ± 0.12 mmol/L. whereas that of control was 1.39 ± 0.12 mmol/L (p>0.05). Using statistical analysis no correlation was noticed between extension of atherosclerosis lesions٫ low total antioxidant capacity and high serum total homocysteine .
Conclusion: In this study no significant differences between levels of homocysteine and total antioxidant in patients and control groups and no marked relationship between studied parameters suggest, that hyperhomocysteinemia has no important role in progress of atherosclerosis lesions.
Azadibakhsh N, Shaker Hosseini R, Atabak Sh, Nateghiyan N, Golestan B, Houshiar Rad A,
Volume 65, Issue 8 (11-2007)
Abstract
Background: Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. The frequency of hyperhomocysteinemia is higher in hemodialysis (HD) patients than the general population. The objective of this study is to assess the efficacy of high-dose folic acid supplementation with and without vitamin B12 on lowering plasma total homocysteine (tHcy) concentrations in HD patients.
Methods: Thirty-six HD patients at Imam Hossein Hospital, Tehran, Iran, who had been given folic acid supplements (5 mg/d) for at least 3 months before, were enrolled in this clinical trial. Subjects were also checked for other inclusion and exclusion criteria. The subjects were divided randomly into four groups and underwent two months of supplementation as follows: 5 mg/d oral folic acid + placebo in group one, 5 mg/d oral folic acid + vitamin B12 (1 mg/d orally) in group two, 15 mg/d oral folic acid + placebo in group three and 15 mg/d oral folic acid + vitamin B12 (1 mg/d orally) in group four. Concentrations of plasma tHcy and serum folic acid and vitamin B12 were measured at baseline and after the supplementation period. Dietary intake of patients was also determined during the supplementation period.
Results: Of the folic acid supplemented patients, 27.8% had normal levels of tHcy at baseline and 72.2% had hyperhomocysteinemia. After the supplementation period, plasma tHcy increased by 1.35% in group one and decreased by 6.99%, 14.54% and 30.09% in groups two, three and four respectively. Changes in plasma tHcy and serum vitamin B12 were only significant in group four however, no significant changes were seen for serum folic acid. The percentage of subjects reaching normal levels of plasma tHcy was 5.6 fold higher in group four than in the reference group.
Conclusions: Supplementation with 15 mg/d folic acid together with 1 mg/d oral vitamin B12 is more effective in reducing tHcy levels in HD patients.
Davari Tanha F, Khan Mohamadi F, Shariat M, Kaveh M, Niroomand N,
Volume 67, Issue 5 (8-2009)
Abstract
Normal
0
false
false
false
EN-US
X-NONE
AR-SA
MicrosoftInternetExplorer4
Background: Increased
total plasma homocysteine (Hcy) is an accepted risk factor of cardiovascular
disease (CVD), stroke, preclampsia, recurrent abortion and diabetes
type I
and II.
The aim of the current study was to assess serum homocysteine and its relation
with serum folat, vitamine B12 and lipid profile in gestational diabetes mellitus
and to compare these with those of pregnant women.
Methods: In a prospective controlled survey 80 pregnant women
(24-28
weeks) with uncomplicated pregnancies were evaluated. They were assigned to one
of two groups according to the results of 100g-OGTT. In the case group there were pregnant women with
gestational diabetes mellitus according to the OGTT and in the control group
women who had normal OGTT results were put. Levels of fasting glucose, homocysteine,
vit B12,
and folic acid, uric acid, total cholesterol, triglyceride, Low Density Lipoprotein
cholesterol (LDL) and High Density Lipoprotein cholesterol (HDL) were
measured in both groups.
Results: The mean level of homocysteine in GDM group was
significantly higher than control group (p=0.000). The mean level of folic acid and vit B12 was
significantly lower than the level in control group (p=0.001, p=0.004
respectively). Body mass index (BMI) in GDM group was higher (p=0.000) and HDL level was
lower (p=0.006) than control group. There were no significant
differences among the groups with respect to levels of total cholesterol and
triglyceride.
Conclusion: We found that patients with gestational diabetes have
higher homocysteine level than normal pregnant women. This increased level
seems to be related to an abnormal OGTT. Further investigations are needed to follow up these
patients in the postpartum period and later on.
Reza Afghani , Ali Aminian , Seyed Rasoul Mirsharifi, Ali Jafarian , Hamid Ghaderi , Morteza Noaparast , Seyed Habibollah Dashti ,
Volume 68, Issue 8 (11-2010)
Abstract
Background: Gall stone is an important health problem in the world for which different risk factors have been characterized. Gall stone and cardiovascular disease have common risk factors. Homocysteine is accepted as one of the risk factors for cardiovascular disease. We aimed to study the effect of homocysteine level on gall stone formation.
Methods: 54 patients with gall stone-related diseases and 54 patients without stone (control group) were studied from January 2007 to December 2008. Control group consisted healthy subjects with ultrasound proven normal gallbladder. Serum homocysteine level was checked in both groups. Homocysteine level of equal or more than 15 mmol/l was considered as abnormally high.
Results: Cases included 43 women (79.6%) and had mean age of 50.76±15.23 years. Homocysteine level was significantly higher in patients with gallstone in comparison to control group (p=0.014). Risk of gall stone increased 3.4 times in persons who have homocysteine level equal or greater than 15mmol/l (p=0.019). The mean level of homocysteine was higher in men than women (p=0.03). The mean level of homocysteine did not differ significantly in patients with simple gallstone and patients with gallstone-related inflammation disorders (cholecystitis, cholangitis, and pancreatitis). Additionally, one unit increase in BMI level was associated with 1.12 times increase in the risk for gall stone formation (p=0.035).
Conclusion: The homocysteine level is increased in patients with gall stone-related diseases. Homocysteine may be considered as a risk factor of gall stone formation.
Bizheh N, Rashidlamir A, Zabihi A, Jaafari M,
Volume 69, Issue 3 (6-2011)
Abstract
Background: Cardiovascular diseases, especially atherosclerosis, are the main causes
of morbidity and mortality worldwide. The disease has had an increasing prevalence in Iran in recent years. Homocysteine and C-reactive protein (CRP) are two novel cardiovascular risk factors that independently predict risks of atherosclerosis. The purpose of this study was to investigate the effects of one session of circuit resistance training on the blood levels of the aforesaid inflammatory markers in inactive middle- aged men.
Methods: The participants of this study included twenty-three healthy but inactive middle-aged men who were overweight and were randomly divided into two experimental (n=14) and control (n=9) groups. The activity included doing exercises with the subjects’ 35% one-repetition maximum (1-RM) intensity at ten different stations. Blood levels of homocysteine and hs-CRP were measured before and after the exercise.
Results: Analysis of data using independent samples t-test showed a significant increment in the serum levels of homocysteine and hs-CRP after training in the experimental (P<0.05) versus the control group.
Conclusion: Elevation of homocysteine levels is due to the increase in protein metabolism and creatine synthesis for energy production and elevation of hs-CRP levels could be due to hepatic induction of interleukin-6 that acts as a signal for the stimulation of lipolysis and glycogenolysis. However, beneficial or adverse physiological effects of these changes are not thoroughly understood and more research is needed to conclude about the acute and chronic effects of different types of physical activity on the blood levels of these atherosclerosis risk factors.
Morteza Noaparast , Seyyed Faramarrz Karimian , Seyyed Rasul Mirsharifi , Abbas Rabbani , Farnoosh Vaezi ,
Volume 71, Issue 4 (7-2013)
Abstract
Background: The purpose of this study was evaluation of risk factors of peripheral artery disease (PAD) and effective markers on it.
Methods: This descriptive-analytical study was done during 2010-2011 in the surgical units of Khorramabad Shohada Hospital. Fifty patients who had symptoms of PAD undergoing CT angiography and biochemical markers for them were measured. The investigated variables were family history, site of arterial obstruction, underlying diseases, smoking history, physical activity and stress level. A control group was considered for the study. The comparison was made between these two groups.
Results: Aging showed a significant role in prediction of PAD (70% sensitivity and 64% specificity). Homocysteine had the highest sensitivity (80%) in prediction of PAD, compared with other biomarkers. CRP (74% sensitivity) was the best marker that had positive predictive value for PAD. Fasting blood sugar (FBS) showed a significant role in prediction of true positive cases of PAD (72% sensitivity and 74% specificity). HbA1C with 68% sensitivity and 64% specificity and TG with 50% sensitivity and 44% specificity could be considered as factors related with PAD.
Conclusion: The levels of C-Reacative protein, homocysteine, and FBS were correlated with PAD, HbA1C and TG levels were associated with PAD, but lower than the previously named markers. In this study a significant relationship between lipoprotein levels and PAD was also observed. PAD was associated with sex and age.
Hossein Fakhrzadeh , Mohamad Jafar Mahmoudi , Zahra Droudian, Farshad Sharifi , Yaser Tajalizadeh Khoob, Neda Mehrdad , Fatemeh Jafaraghaei , Zohreh Badamchizadeh ,
Volume 74, Issue 3 (6-2016)
Abstract
|
Background: The relationship between serum homocysteine levels and cardiovascular diseases has been elucidated since many years ago. In this study, the association between serum levels of homocysteine, folic acid, and vitamin B12 with the pulse wave velocity and Buckberg index or subendocardial viability ratio was assessed in individuals with diabetes and also non-diabetic subjects.
Methods: In this cross-sectional study, 58 individuals with type 2 diabetes and 36 non-diabetic people, from April to October 2013 were enrolled in Dr. Shariati Hospital affiliated to Tehran University of Medical Sciences. Anthropometric and blood pressure measurements were performed with standard methods. Fasting serum glucose, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, Triglyceide, A1C, vitamin B12, folic acid and serum homocysteine levels as well as, highly sensitive complement-reactive protein (hs-CRP) were measured. Artherial stiffness was assessed by calculating pulse wave velocity and aortic agumentation index via Sphygmocor. In addition, Buckberg index (Subendocardial viability ratio) was assessed by dividing myocardial oxygen supply to dimand expressed as percent. The normality of distributions was evaluated by Kolmogorov-Smirnov test and linear regression models were utilized to detect associations.
Results: Diabetic and non-diabetic subjects differed in terms of age, history of hypertension, serum levels of homocysteine, and LDL-C (P< 0.05). The pulse wave velocity in subjects with diabetes and without diabetes were 60.91 m/s and 41.91 m/s, respectively (P= 0.01). After adjustment for confounding factors in multivariate regression analysis pulse wave velocity was associated with age and homocysteine levels in non-diabetic group, (β equal to 0.441 and 0.345, respectively), and it was related to age, diastolic blood pressure and serum levels of c-reactive protein in subject with diabetes (β= 0.417, 0.302, and 0.262, respectively).
Conclusion: Homocysteine levels in non-diabetic individuals were associated to sub-clinical atherosclerosis markers but we could not find this association in diabetic participants.
|
