Showing 5 results for Vitamin C
Bogaee N, Shidfar F, Keshavarz S A,
Volume 62, Issue 1 (4-2004)
Abstract
Background: Vitamin C is a major antioxidant in lung airways and also functions against external insulting oxidant sources such as smoke and environmental contaminants. The aim of study was to assess the vitamin C in asthmatic patients, by it’s measurement in plasma and white blood cells (WBC).
Materials and Methods: In a case–control study 50 asthmatic patients and 50 healthy person were randomly selected. The data were obtained by utilizing socioeconomic questionnaire and 24 hour dietary recall. l0 c.c blood samples were drawn. Plasma and WBC vitamin C concentration were measured colorimetrically. The data were analyzed by FPI and SPSS software.
Results: The results indicate that 38 percent and 92 percent of patients had deficient plasma and WBC vitamin C concentrations respectively. There was a significant difference in plasma and WBC vitamin C concentrations among patients and control group (P<0.0001) Analysis of regression showed that a significant dependence was observed between the duration of asthma and plasma vitamin C status (P=0.03), though a positive significant correlation was obtained between plasma vitamin C status and dietary vitamin C intake (P=0.0001, r =0.56), The interaction of socioeconomic parameters and vitamin C concentration in asthmatic patients in this study was not significant .
Conclusion: Present study indicates that while there is an association between vitamin C status and asthma but WBC vitamin C status is more sensitive in this regard and deserves further study and consideration.
Farvid Ms, Siasi F, Jalai M,
Volume 64, Issue 10 (10-2006)
Abstract
Background: The present study designed to assess the effect of Mg+Zn, vitamin C+E, and combination of these micronutrients on glycemic control and insulin resistance in type 2 diabetic patients
Methods: In a randomized, double-blind, placebo controlled clinical trial, 69 type 2 diabetic patients were randomly divided into four groups, each group receiving one of the following daily supplement for 3 months group M: 200 mg and 30 mg Zn (n=16), group V: 200 mg vitamin C and 150 mg vitamin E (n=18), group MV: minerals plus vitamins (n=17), group P: placebo (n=18).Fasting blood glucose, fructosamine, HbA1c and serum insulin were measured at the beginning and at the end of 3 months supplementation. Insulin resistance was calculated by HOMA score. Treatment effects were analyzed by general linear modeling.
Results: After 3 months of supplementation fasting blood glucose decreased in MV group (165±46 vs 177±41 mg/dl, p=0.035). There was no significant change in fructoseamin, HbA1c, serum insulin or insulin resistance in treatment groups.
Conclusion: The results of the present study provide evidence for the effects of combination of Mg, Zn and vitamin C and E supplementations on improvement of fasting blood glucose but not fructosamine, HbA1c, serum insulin or insulin resistance in type 2 diabetic patients.
Ali Bidmeshkipour, Abaslt Hosseinzadeh Colagar, Maryam Gholinezhad Chari, Pourya Biparva,
Volume 67, Issue 12 (3-2010)
Abstract
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Background: Defective sperm function is now recognized as
one of the most important causes of male infertility. Seminal plasma possesses
a rich source of different enzymatic and
non-enzymatic antioxidants such as vitamin C (ascorbic
acid) that protect spermatozoa against oxidative stress as one of the mediators
of infertility causing sperm dysfunction and low sperm quality. The
aim of this study was investigation of seminal total antioxidant capacity and determination
of vitamin C effects on sperm
motility.
Methods: We designed a case-control study with a total
subject of 62 males. Sperm
parameters were analyzed according to World
Health Organization
guidelines (WHO, 1999).
Total antioxidant capacity and vitamin C
level of seminal plasma were measured in the 32
normozoospermic as the control group and 32
asthenospermic men as the case group using FRAP
(Ferric Reducing of Antioxidants
Powers)
and RP-HPLC (Reverse Phase
High Performance
Liquid Chromatography)
methods, respectively.
Results: Our results indicated that total antioxidant
capacity levels in the seminal plasma of asthenospermic men were significantly
lower than healthy men (p=0.002).
In addition, we found a positive correlation
between reduced total antioxidant capacity levels and low sperm motility. Vitamin
C levels of seminal plasma in asthenospermic men
were statistically lower than control men (p=0.01).
Conclusions: It is suggested that asthenospermia could be
related to an antioxidant deficiency or it&aposs reduction.
Mahmoodreza Sarzaeem , Nasim Shayan ,
Volume 71, Issue 12 (3-2014)
Abstract
Background: Atrial fibrillation is the most common arrhythmia after cardiac surgery. Vitamin C as an antioxidant has an important role in reducing the incidence of postop-erative atrial fibrillation. The present study aimed at administrating vitamin C as a way to reduce the incidence of post-CABG atrial fibrillation.
Methods: In this double-blind, parallel clinical trial, 170 patients with coronary artery disease who underwent CABG surgery, by using a table of random numbers are di-vided into intervention and control groups to receive placebo or vitamin C. The clinical and surgical characteristics of the patients in the two groups were similar. The interven-tion group received 2 mg of vitamin C intravenously, the night before surgery. This drug followed by 500 mg, twice a day for five days after surgery. On the other hand patients in the control group received placebo (normal saline intravenously). After operation two groups were compared regarding Important outcomes such as postoperative arrhythmia, ICU stay and hospital stay.
Results: One hundred eighteen men and fifty two women with a mean age of 59.1±9.8 years were enrolled in the study in two vitamin C and placebo groups (each consisting of 85 patients). The incidence of postoperative atrial fibrillation was 12.9% in the vita-min C group and 29.4% in the control group (P=0.009). ICU stay in the vitamin C group were 2.5±1.4 days versus 3.0±1.6 days in controls (P=0.035) and hospital stay in the vitamin C group were 6.6±1.5 days versus 8.2±2.3 days in controls (P<0.001).
Conclusion: Vitamin C is relatively safe, inexpensive, well tolerated and has a low complication. According to the 44% reduction in the incidence of atrial fibrillation in vitamin C patients undergoing coronary artery bypass grafting surgery, this drug can be prescribed as a prophylaxis for prevention of post-CABG atrial fibrillation.
Jalal Moludi , Seyedali Keshavarz , Reza Pakzad , Naser Sedghi , Taraneh Sadeghi , Foad Alimoradi,
Volume 73, Issue 11 (2-2016)
Abstract
Background: Recently, the role of inflammation and oxidative stress in the pathophysiology of atrial fibrillation (AF) after cardiac surgery has been emphasized. Vitamin C as an antioxidant important role in reducing the incidence of postoperative atrial fibrillation. This study aimed to investigate, administration of vitamin C, as a way to reduce the incidence of atrial fibrillation after coronary bypass surgery.
Methods: In this double-blind clinical study, 290 patients in Rajaee Heart Center, from March 2013 to December 2014 who underwent coronary artery bypass surgery were randomly divided into intervention and control groups to receive vitamin C and placebo. The intervention group before the surgery in the operating room received 2 grams of vitamin C intravenously then one gram per day for four days prior to surgery. After the operation, the two groups were compared in terms of the following: Atrial and ventricular arrhythmias after surgery, ICU stay and hospital stay and duration of intubation.
Results: 113 cases and 177 controls (191 men and 99 women) with a mean age of 55.40±14.40 years in both groups (vitamin C and placebo) were enrolled. The incidence of postoperative atrial fibrillation was 55% in the placebo group to 35% in the vitamin C group decreased (P= 0.001). Duration of intubation in the intervention group 11.8 and the control group was 14.14 hours (P= 0.004). The amount of drainage was lower in vitamin C group (P= 0.003). Vitamin C had no effect on the rates of hospital and ICU stay (P= 0.075). There was no significant reduction in threatening arrhythmia (VT) and VF in this period (P= 0.159).
Conclusion: Vitamin C supplements may reduce atrial fibrillation after coronary artery bypass surgery also can improve conditions such as reducing the duration of intubation. With regard to the safety, these supplements can be recommended for the prevention of atrial fibrillation before coronary artery bypass surgery.
