Tehran University Medical Journal

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Background: Adipokines are peptides secreted by adipose tissue that affect whole-body energy metabolism. Exercise training exerts beneficial effects on adipose tissue. However, less is known regarding visfatin’s, IL-6 & TNF-α response to an interval acute training. Therefore, we investigated the effects of acute interval exercise on plasma visfatin, TNF-α and IL-6 levels, in healthy female rats. Furthermore, correlate between changes probably these factors were also assessed.
Methods: This study was conducted experimentally. Forty five female sprague dawley rat were randomly divided into three groups: pre test (n= 15), treadmill exercise (n= 15) and sedentary controls (n= 15). The acute alternative exercise consisted of treadmill running: 3 session/ week for 8 week. The changes of plasma IL-6, TNF-α and Visfatin levels were measured by ELISA analysis. Data were analyzed using analysis of variance with measures (ANOVA) and post hoc Tukey test.
Results: Acute interval treadmill exercise led to significant decreases in visfatin (P= 0/036), IL-6 (P= 0/009) and TNF-α (P= 0/022) plasma levels between the groups. Also, this study no significant correlations between the changes in adipokines were observed.
Conclusion: Decreased levels of TNF-α and IL-6 correlated with intensity and duration exercise. Furthermore, probably there were some factors except weight decreasing that affects on visfatin decrease. Therefore, the reduction of this factor may cause in preventing metabolic disease.

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Background: The goal of the study was to investigate the effect of 5 weeks of high-intensity interval training (HIIT) on the levels of resistin and adiponectin and liver enzymes in Wistar rats with non-alcoholic fatty liver.
Methods: To do this basic research, 24 Wistar male rats were purchased and transferred to Baqiyatallah University then, they were allocated randomly into three groups: Control group (CG, n=8), induced fatty liver diseases group (FG, n=8), and induced fatty liver diseases+exercise group (FEG, n=10). The present study was conducted in July and August of 2019. To induce fatty liver disease, 140 mg per kg of bodyweight oral tetracycline drug was administered to rats by gavage for seven days. Fatty liver (steatosis) was confirmed by measuring liver enzymes. The training group performed HIIT for five weeks and five days per week. First, the maximum aerobic test (MAT) was performed, and based on data of this test; the HIIT protocol was conducted as 5×2 min-intervals with (50-120% Mat) and with 1 min recovery (30-50% MAT). Blood and tissue sampling were taken 48 hours after the last training session. Blood samples were centrifuged at 4000 rpm for 10 minutes, and serum samples were frozen at -20 degrees. One-way ANOVA and Tukey post hoc test were used to analyze data.

Results: Following performing HIIT, serum levels of adiponectin and resistin in the FEG compared to FG increased and decreased significantly, respectively (P=0.001). In addition, the FEG experienced a significant decrease in serum levels of AST and ALT enzymes. The aerobic capacity of the rats in the HIIT group increased significantly compared to the other two groups. Conclusion: By modulating body fat levels and the secretion of adipokines such as adiponectin and resistin, HIIT was involved in improving the condition of rats with non-alcoholic fatty liver disease.