Search published articles


Showing 5 results for Adiponectin
Umbilical cord versus maternal serum leptin and adioponectin levels: a comparative study in small and appropriate for gestational age newborns
Marsoosi V, Mortazavi M, Zakeri Hr, Jamal A,
Volume 67, Issue 7 (10-2009)
Abstract

Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Background: The mechanisms by which fetal weight are regulated during pregnancy are poorly understood. The relation between hormones such as leptin and adiponectin and intrautrine growth is still under investigation. The aim of this study was to ascertain whether fetal growth restriction is associated with alterations of leptin and adiponectin  concentrations in venous umbilical cord blood and maternal serum.
Methods: Maternal serum and venous umbilical cord blood leptin and adiponectin concentrations were determined by ELISA after 36 week of gestational age in 22 women with uncomplicated singleton pregnancies with AGA fetuses (group A) and in 22 women with singleton pregnancies complicated by fetal growth restriction but without fetal distress (group B), all with normal body mass index and without history of diabetes, hypertention or maternal cardiac disease.
Results: Venous umbilical cord leptin levels were significantly lower in group B compared with group A (8.1±0.8ng/ml versus 39.45±6.8ng/ml p=0.001). Venous umbilical cord adiponectin levels were also significantly lower in group B compared with group A (28.8±3.5μg/ml versus 43.6±3.7μg/ml p=0.007). Maternal serum leptin and adiponectin did not differ between SGA and AGA groups.maternal BMI, gestational age and maternal age did not differ between these two groups. Neither leptin nor adiponectin correlated with gender difference.
Conclusion: In this study we confirmed that growth restricted fetuses show venous umbilical cord blood leptin and adiponectin concentrations were significantly lower than those in normal fetuses indicating that these two adipokines have an independent role in growth restriction pathogenesis. Maybe in future we can administer recombinant human leptin and adiponectin to growth restricted fetuses for treatment.


The effects of an eight-week aerobic training program on plasma adipokine concentrations in middle-aged men
Rashidlamir A, Saadatnia A,
Volume 69, Issue 2 (5-2011)
Abstract
Background: Obesity is currently a worldwide health epidemic which has incited major interest among researchers to look for the underlying mechanisms that regulate body weight. In fact, adiponectin and leptin concentrations that are called adipokines are altered in obesity with a decreased production of adiponectin and an increased production of leptin. Adiponectin has anti-inflammatory, anti-atherosclerotic and anti- insulin resistance properties, but increased levels of leptin are observed in patients with diabetes and cardiovascular diseases. The aim of the present study was to investigate the effects of an 8-week aerobic training program on the plasma levels of adiponectin and leptin in healthy middle-aged men. Methods: Thirty healthy middle-aged men were selected based on their body fat percentage and were assigned to two equal groups. The experimental group took the 8- week training, four days a week on alternate days with an intensity of 60-80% of their heart rate reserve but the control group lived their sedentary life. Blood samples were collected before and after the training program from all subjects and plasma adipokine levels were measured. Results: Plasma adiponectin concentration increased while leptin levels decreased significantly (P<0.001 and P≤0.042 respectively) upon completion of the 8-week program. Moreover, reduction in body fat percentage (P≤0.001) negatively correlated with adiponectin (P≤0.001) and positively with leptin changes (P≤0.008). Conclusion: In healthy middle-aged men, 8-week aerobic training programs could reduce body fat percentage and improve plasma adipokines levels. Therefore, aerobic training can be considered as a major strategy for preventing obesity and its accompanying diseases.
Adiponectin and markers of subclinical atherosclerosis in early type 2 diabetes: Evaluation of carotid artery intima-media thickness and coronary artery calcium score
Hossein Fakhrzadeh , Farshad Sharifi , Neda Mehrdad , Fatemeh Jafaraghaeii , Zohreh Badamchizadeh , Neda Nazari ,
Volume 71, Issue 7 (10-2013)
Abstract

Background: The aim of this study was to assess the association of serum adiponectin and a set of traditional cardiovascular risk factors with carotid artery intimal-medial thickness (CIMT) and coronary artery calcium score (CACS), as markers of subclinical atherosclerosis in subjects with early type 2 diabetes mellitus.

Methods: Carotid artery intima- media thickness (measured by B-mode ultrsonography), coronary artery calcium score (determined by high resolution computed tomography), serum adiponectin, Fasting blood sugar, serum lipids, body mass index (BMI), systolic blood pressure, diastolic blood pressure and mean arterial pressure were measured in 123 asymptomatic newly diagnosed cases of type 2 diabetes mellituss and 152 age and sex matched healthy control subjects.

Results: Serum adiponectin and lipids were significantly lower in those with type 2 diabetes mellitus (P<0.01). Left, right and mean carotid artery intima- media thickness, coronary artery calcium score, fasting blood sugar, systolic blood pressure, diastolic blood pressure and mean arterial pressure were significantly higher among diabetic patients compared to healthy controls (P<0.05). Mean carotid artery intima- media thickness was positively and independently related to age (P<0.001) and triglyceride (P=0.01) in diabetic group. Coronary artery calcium score was associated positively with age (P=0.004) and inversely with high density lipoprotein (HDL) cholesterol (P=0.002) among diabetics.

Conclusion: Although adiponectin was lower in diabetics compared to controls, it had no significant association with carotid artery intima- media thickness and coronary artery calcium score as markers of subclinical atherosclerosis. In patients with type 2 diabetes in addition to age, serum triglyceride levels are correlated with carotid artery intima- media thickness, while HDL cholesterol is inversely correlated with coronary artery calcium score.


Effects of resistance training on serum levels of undercarboxylated osteocalcin, adiponectin and insulin sensitivity in obese women
Yasaman Alipour , Asieh Abbassi Daloii , Alireza Barari , Ahmad Abdi ,
Volume 73, Issue 9 (12-2015)
Abstract

Background: Undercarboxylated Osteocalcin (ucOC) may contribute to the regulation of glucose homeostasis. Undercarboxylated osteocalcin is special protein secreted by bone as an endocrine regulation of energy metabolism and glucose. It plays an important role in insulin secretion and sensitivity. The aim of this study was to survey the effect of eight weeks resistance training on serum levels of ucOC, adiponectin and insulin sensitivity in obese women.

Methods: This quasi-experimental study performed on twenty obese women (BMI> 30) in Amol City Sport clubs, Iran, in May 2014. Samples randomly divided into two groups: a control group and an experimental group.  The experimental group consisted of eight weeks of resistance training, three times a week in six stations (including the movements of the leg press, bench press, triceps, biceps, abdominal motion, pull side and half scott) and with an intensity of 55% to 75% of one repetition maximum. Blood samples were collected after 12- 14 hours, fast and before it and also after eight weeks (48 hours after the last training session). Kolmogorov-Smirnov test was performed to confirm that data was normally distributed. The obtained data was analyzed using paired-sample t-test, independent t-tests and one-way ANOVA at the significance level of P< 0.05.

Results: The results showed that resistance training had no significant effect on serum ucOC (P= 0.094) levels and insulin sensitivity (P= 0.178) in obesity. However, the experimental group after resistance training showed significantly higher adiponectin level than the upper limit of normal range (P= 0.003). There was no relationship between adiponectin and ucOC.

Conclusion: Resistance exercise can increase levels of serum undercarboxylated osteocalcin (ucOC) and adiponectin in obese women. It can be said that this type of activity could possibly be effective in glucose hemeostasis.


Alterations of adiponectin gene expression in bone marrow of acute myeloid leukemia
Seyed Hossein Abtahi , Mohammad Hossein Mohammadi , Mehdi Allahbakhshian Farsani ,
Volume 78, Issue 2 (5-2020)
Abstract
Background: Acute myeloid leukemia (AML) is characterized by the proliferation of myeloid precursors and abnormal differentiation of hematopoietic stem cells, which results in the accumulation of immature cells in the bone marrow (BM). The accumulation of these cells in the bone marrow causes molecular and cellular changes in the microenvironment of the bone marrow. The adiponectin hormone originates from adipose tissue of the bone marrow, which in addition to effective functions in cellular metabolism, suppresses cancer through various mechanisms, including inhibition of metastasis, angiogenesis, and proliferation. In the bone marrow sample, patients with acute myeloid leukemia are associated with different subtypes of the disease.
Methods: In this basic-fundamental research, a total of 40 BM samples from de novo AML patients and 15 BM samples from healthy volunteers as the healthy group referred to the Stem Cell Transplantation Laboratory and Cell Therapy of Taleghani Hospital and with assisting the Research Center, Shahid Beheshti University of Medical Sciences, Tehran, from March 2015 to February 2017, were entered into the study. Then used the Real-time polymerase chain reaction (RT-PCR) method for diagnosis level of adiponectin gene expression in BM samples patients and the healthy group.
Results: The results of the present study showed that the level of adiponectin gene expression in the BM sample of patients was significantly decreased in comparison with the healthy group (P=0.002). While, there was no significant difference (P<0.05) in adiponectin gene expression in AML subtypes myeloblastic, promyelocytic, and myelomonocytic/monocytic.
Conclusion: The results of this study indicate that there was a decrease in adiponectin gene expression in the bone marrow of acute myeloid leukemia patients compared to healthy controls. This decrease in adiponectin expression may be due to myeloid hyperplasia and a decrease in bone marrow adipocytes. In fact, The nutritional, metabolic, and mechanical stresses associated with myeloid cells accumulation cause alterations in bone marrow microenvironment structure and destruction of bone marrow adipose tissue. Therefore, reduced adiponectin gene expression in AML patients is one of the key indicators of bone ‎marrow microenvironmental changes in AML patients.‎‎

Page 1 from 1     

© 2024 , Tehran University of Medical Sciences, CC BY-NC 4.0

Designed & Developed by : Yektaweb