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A 36 years old woman with Hutchinson-Gilford Progeria Syndrome: a case report
Akrami S M, Yousefzadeh G R,
Volume 65, Issue 9 (12-2007)
Abstract

Background: Hutchinson-Gilford Progeria Syndrome (HGPS) is a very rare genetic disorder with a frequency of 1 in 8 million live births. It is characterised by premature aging phenotype. The median age at death is 13.4 years. It is an autosomal dominat disease due to a de novo point mutation in the Lamin A gene exon 11 in the majority of cases. More than 100 cases have been reported world wide.
Case report: We describe here an exceptionally long-lived patient with HGPS, who is alive at age 36. She was referred by a cardiologist to our endocrinology clinic to be worked up for presence of a metabolic or genetic disorder before a heart surgery.
Results: Having more attention of clinicians about very rare diseases and referring the patients to geneticist are the main goals of this case report as well as describing the disease.


Frailty effects and euro score system evaluation in postoperative outcomes of cardiac surgery patients
Behnam Askari, Mojgan Hajahmadi-Poor Rafsanjani , Parin Hamidi-Azar ,
Volume 79, Issue 3 (6-2021)
Abstract
Background: Several scoring systems are available to evaluate the cardiac surgery risk. Frailty increases the risk of adverse outcomes after surgery. The Frailty evaluation system is a relatively new method, and in this study, we compared the frailty scoring method with the conventional Euroscore method.
Methods: This cross-sectional study was performed on 88 elderly patients (over 65 years of age) undergoing coronary artery bypass graft surgery in Seyed al Shohada Heart Center, Urmia, Iran, from October 2019 to March 2020. Patients undergoing other cardiac surgeries, patients with left main coronary artery involvement, patients with low-threshold chest pain, and life-threatening emergencies were excluded. At the preoperative period and based on the CAF (the Comprehensive Assessment of Frailty) Scoring System and the EuroScore system, the total score was calculated for each patient. Patients were followed up until one month after surgery in terms of morbidity and mortality. Patients' data were analyzed and the correlation between the total score of both systems and the postoperative consequences were statistically analyzed.
Results: In this study, the mean age of patients was 70.84±5.07 (65-91) years and most of the patients were male, 65(73 9%).The mean ejection fraction of patients was 44.13±5%. Twelve patients (13.6%) had mild frailty (CAF score of 1 to 8), 74 patients (84.1%) had moderate frailty (CAF score of 9 to 18) and 2 patients (2.3%) had severe frailty (CAF score of 19 to 28). In the postoperative period, there were two cases of mortality (2.3%) and four cases of complications (4.55%). The mean serum creatinine level in dead patients was significantly higher than in discharged patients. We did not find any significant relationship between frailty CAF score and EuroSocre with postoperative complications. In a comparison of two methods for predicting surgery outcomes: the mean EuroScore in the two dead patients was significantly higher than discharged patients (8.11 vs 2.89 with p value=0.001).
Conclusion: EuroSocre evaluation was a better predictor of postoperative mortality and its measurement is easy.

Investigating factors affecting happiness in postmenopausal women: a systematic review
Zeinab Khazee Shir , Samira Ebrahimzadeh Zaghmi,
Volume 82, Issue 7 (10-2024)
Abstract

Background: Menopause is one of the most important stages in women's lives. Today, menopause is an important phenomenon due to the increase in life expectancy, the number of postmenopausal women is expected to reach 1.2 billion by 2030. It is important for women to live healthy in these years as in the reproductive years. One of the main psychological needs of humans is happiness. According to studies, happiness decreases during menopause. As a result, considering the importance of the topic, this study was conducted with the aim of determining the factors affecting happiness in menopausal women.
Methods: In order to compile this review article, searching for articles using the keywords happiness, menopause, middle-aged women, alone and in combination with AND and OR operators in databases ,such as PubMed, Scopus, Science direct, ProQuest, SID, Magiran and Google Scholar search engine without time limit. At first, 125 articles were found. The inclusion criteria were all studies that had investigated the factors affecting happiness. The reviewed studies included clinical trials, cohort and cross-sectional, and finally the data of 29 articles were used.

Results: The results of this study led to the classification of factors affecting the happiness of postmenopausal women into five general categories. The first category includes physical factors (including the absence of: vasomotor symptoms, cardiovascular diseases, arthritis, osteoporosis, psychosomatic disorders and having a favorable condition. health). The second category includes psychological factors (including the absence of depression and anxiety, having a positive attitude towards menopause, optimism, self-esteem and resilience). The third category includes social factors such as (social support of family and friends, effective communication with colleagues). The fourth category is economic factors (including job changes, favorable income level and the absence of financial crises). The fifth category includes lifestyle (being non-smoker, having physical activity and regular exercise, marital satisfaction, stress management skills and herbal drugs) of menopausal women.
Conclusion: In order to improve the happiness of menopausal women, all physical, psychological, social, economic and lifestyle factors are important and should be considered in national planning and policies to improve the health of menopausal women.


The effect of eight weeks of physical activity with vitamin D supplementation on endothelial indices in hypertensive patients
Mozaffar Jan Faza, Mohammad Rahman Rahimi ,
Volume 82, Issue 7 (10-2024)
Abstract
Background: The aim of our study was to evaluate the effect of 8 weeks of aerobic exercise with vitamin D supplementation on indulin-1 and nitric oxide in patients with hypertension aged 30 to 50 years.
Methods: This study was conducted as a semi-experimental pre-test and post-test design, and was conducted from June 1401 at Seyyed Shohada Hospital in Urmia. 40 eligible men and women were randomly divided into four groups (supplement group, placebo + exercise group, a supplement + exercise group, and a control group). The training program of the experimental groups included eight weeks of aerobic exercise running on a treadmill (3 sessions/8 weeks). Blood sampling to evaluate biochemical variables was performed 48 hours before and after the intervention in a fasting state with a volume of 10 cc.
Results: The results of the study show that after 8 weeks of aerobic exercise, vitamin D, BMI, NO, ET-1 and weight were significantly affected (P < 0.05) and systolic blood pressure in the supplement, supplement + exercise and exercise + placebo groups changed compared to the control group(P < 0.05).
Conclusion: Based on the results of the present study, the results showed that taking eight weeks of vitamin D supplements along with aerobic activity reduced blood pressure indices in the subjects. Also, taking vitamin D supplements along with physical activity reduced BMI and increased NO, reduced ET-1 and body weight in the subjects in the study.

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