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Comparison of the growth hormone, oxandrolone, letrozole and anastrozole’s impact on the height increase in children and adolescents with idiopathic short stature (ISS): a systematic review and meta-analysis
Samira Shiri , Mahmoud Ghasemi, Khairollah Asadollahi, Maryam Deldar , Kourosh Sayehmiri ,
Volume 79, Issue 9 (12-2021)
Abstract
Background: Short children face many problems throughout their lives. Consumption of growth hormone and the drugs such as Letrozole, Oxandrolone, and Anastrozole can increase the growth of children and adolescents. There is not an overall estimate of the effects of Letrozole, Oxandrolone, and Anastrozole on the growth of children and adolescents with Idiopathic Short Stature (ISS). There are different estimates of the effect of growth hormone and the drugs Letrozole, Oxandrolone, and Anastrozole on growth in children and adolescents with Idiopathic Short Stature. Therefore, the aim of this study was to compare the efficacy of growth hormone, Letrozole, Oxandrolone, Anastrozole, and a combination of growth hormone and aromatase inhibitors on height gain in children and adolescents with idiopathic short stature using meta-analysis method.
Methods: Search was done in databases such as; Scopus, Web of Science(ISI), and PubMed using keywords: Idiopathic, Short Stature, Body Height, Aromatase Inhibitors, Growth hormone, Letrozole, Oxandrolone, Anastrozole. Randomized clinical trial studies ,that have investigated the efficacy of growth hormone and aromatase inhibitors on height gain in children and adolescents with short stature, were selected. Height standard deviation score (HSDS) before intervention and after treatment has been used to measure the rate of height increase in various studies. This study was written based on the PRISMA checklist and the heterogeneity of this study was evaluated using the Q statistic and I2 index.
Results: Height increase index (HSDS) was obtained with the use of growth hormone combined with one of the aromatase inhibitors (0.38-3.58=95%CI) (SMD=0.98), with the use of growth hormone (0.62-1.14=95%CI) (SMD=0.88), with the use of Letrozole (0.51-16.51=95%CI) (SMD=0.83), with the use of Oxandrolone (0.99-0.99=95%CI) (SMD=0.56), and with the use of Anastrozole (0.00-0.63=95%CI) (SMD=0.31), which shows that all these drugs have a significant effect on height increase. (P<0.05)
Conclusion: Although the effect of growth hormone on height increase was greater than that of aromatase inhibitors, but according to our results, adding an aromatase inhibitor to growth hormone can increase the effectiveness of it.

Stature estimation by lower limb anthropometry in Iranian medical students
Shokoofeh Kazemzadeh, Maryam Khanehzad, Sina Mojaverrostami, Soheila Madadi, Tahereh Alizamir,
Volume 82, Issue 8 (11-2024)
Abstract
Background: Estimating the stature and identifying unknown bodies is an important challenge for forensic specialists and anthropologists, especially when dismembered and mutilated body parts are found. The purpose of this study was to predict the stature by measuring lower limb parameters and to determine the relationship between stature and thigh length, leg length, foot length and lower limb length in Iranian medical students.
Methods: This study was conducted in the Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran in 2019 (May-August). The study population consisted of 200 Iranian medical students (100 males and 100 females, aged 17-36 years). Four lower extremity parameters (thigh length, leg length, foot length, and lower limb length) and stature were measured on the left side according to standard measurement methods. All measurements were performed according to ethical standards provided by the Ethics Committee for Human Experimentations. The measurements were done using standard anthropometric instruments. Linear regression analysis was used to investigate the relationship between the stature and the lengths of the four lower extremity parameters. Then, stature prediction was done based on regression equations. The data were analyzed using SPSS version 25. Independent-samples t-test was used to compare the mean values of the anthropometric measurements between males and females. The relationships between quantitative data were evaluated using the Pearson’s correlation coefficient and linear regression was applied to determine the relationship between stature and lower extremity parameters.
Results: The results of this study indicated a strong correlation between stature and lower limb length (r=0.892, P=0.000), foot length (r=0.852, P=0.000) and thigh length (r=0.805, P=0.000) and a moderate correlation between stature and leg length (r=0.505, P=0.000).
Conclusion: The results of this study suggest that lower limb dimensions and regression equations are appropriate for stature estimation in forensic medicine. However in the future, further research should be conducted to analyze the applicability of these equations for stature estimation in other Iranian populations.

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