Rashidlamir A, Hashemi Javaheri A, Jaafari M,
Volume 68, Issue 12 (3-2011)
Abstract
Background: Coronary heart disease is one of the most common causes of death in developed
countries. Fibrinogen and resistin are two inflammatory markers used for atherosclerosis risk prediction. The aim of this study was to examine the
effects of eight weeks of aerobic exercise on the concentrations of fibrinogen and resistin in healthy overweight middle-aged men.
Methods: Thirty inactive middle-aged men with a body mass index of 25-30
were randomly assigned into two experimental and control groups. The participants in the experimental group, accomplished eight weeks (3
sessions per week, of aerobic exercise with an intensity of 50-70% of their maximum heart rate while the control group remained sedentary. Weight,
body fat percentage, fibrinogen and resistin levels of the participants were measured 48 hours before the first and after the last training sessions. The obtained data were analyzed using Independent Samples T-tests.
Results: There were significant reductions in weight, body mass index, body fat percentage and fibrinogen and a significant elevation in resistin concentration in the experimental group (p<0.05) upon the
exercises relative to the control group.
Conclusion: It seems that eight weeks of regular aerobic exercise could reduce risks of
myocardial infarction and improve the health status of overweight middle-aged men through reduction of weight, body fat and fibrinogen and elevation of
resistin concentrations. Elevation of resistin concentration can be a sign of increased antioxidant defense mechanism.
Mahmoud Ebrahimi , Mohammad Karimi , Faranak Dehghani , Amir Biriaei , Nafiseh Farhadian, Shiva Golmohammadzadeh ,
Volume 77, Issue 3 (6-2019)
Abstract
Background: Sesame oil can be used to treat cardiovascular diseases, such as atherosclerosis, by reducing the levels of fibrinogen and factor VII. The aim of this study is to prepare a microemulsion containing sesame oil as a drug nanocarrier for improving the aqueous solubility and therapeutic effects of this vegetable oil on the reduction of the fibrinogen and factor VII levels in animal model.
Methods: This experimental study was performed for microemulsion preparation and animal test at Ferdowsi University of Mashhad and Cardiovascular Research Center of Mashhad University of Medical Sciences, Mashhad, Iran, respectively, from April 2015 to January 2017. To prepare the microemulsion samples, Tween 80 and span 80 were selected as surfactant couple and surfactant ratios of 8:1, 9:1 and 10:1 were determined for construction of pseudo-ternary phase diagrams. The Zealand white rabbits were categorized in three groups: receiver of base diet group, high cholesterol diet and high cholesterol diet plus microemulsion.
Results: The average particle size of the samples was in the range of 16.64±0.1 to 21.16±0.2 nm with a uniform particle size distribution. Zeta potential was in the range of -10.7 to 18.4 mV, refraction index was approximately 1.39. Electrical conductivity coefficient was in the range of 297 to 311 μz and pH of all the samples were approximately 6.42 for all samples. All of the microemulsion samples were physically stable and the prepared sample with 9:1 surfactant ratio was selected to investigate the animal test due to the higher oil percentage in comparison with the other samples that be stable over 6 months. Significant decrease in the levels of fibrinogen and factor VII in the third group of rabbits was observed compared to the other groups.
Conclusion: The results of this study showed the effective performance of nanostructured drug delivery systems in the form of microemulsion to improve the aqueous solubility and therapeutic effects of hydrophobic compounds such as vegetable oils.
