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Showing 5 results for Heart Failure
Relationship between advanced glycation end-products with the severity of chronic heart failure in 85 patients
Amir Farhang Zand Parsa, Soudabeh Nejati , Alireza Esteghamati ,
Volume 71, Issue 9 (12-2013)
Abstract
Background: Advanced glycation end-products (AGEs) came up with the recent researches regarding new biomarkers for the diagnosis of heart failure. AGEs are the end products of non-enzymatic glycation and oxidation of proteins, lipids and nucleotides during Maillard biochemical reaction. Although it has been known that AGEs have a role in the pathogenesis of chronic heart failure (CHF), information regarding its role and its pathogenetic mechanism is very limited. The aim of this study was to find any relationship between AGEs with the etiology and severity of chronic heart failure.
Methods: This study is a prospective cross sectional study that enrolled 85 patients with chronic heart failure. Measurement of left ventricle ejection fraction (LVEF) was done by echocardiography. Blood samples were collected for measuring AGEs just before or after echocardiography assessment (in the same session). Measurement of AGEs was done by the enzyme-linked immunosorbent assay (ELISA) method. The relationship between AGEs with the severity of CHF and as well as the etiology of CHF were evaluated via SPSS-15.
Results: Of 85 patients 48 (56.5%) patients were male and 37 (43.5%) were female Mean±SD of their ages was 55.8±13.4 years old (ranges from 27 to 84 years). Correlation coefficient between LVEF and AGEs was 0.269 (P=0.013). Mean of AGEs in patients with and without ischemic etiology of their heart failure were 16.8±9.8µg/ml and 11.6±7.3 µg/ml, respectively. Although trend was in favor of ischemic heart failure, the difference between two groups was not statistically significant (P= 0.141).
Conclusion: According to this study the rate of AGES could be helpful in the diagnosis and assessment of severity of CHF. Based on our findings, higher blood levels of AGEs in the ischemic CHF cases, also it could be concluded that in the future this marker may be used for etiologic differentiation of heart failure syndrome.

A newborn infant with congenital cerebral arteriovenous malformation, and congestive heart failure: case report
Hamed Tabasizadeh , Foroud Salehi , Marzieh Eslami Moayyed, Marieh Eslami Moayyed ,
Volume 75, Issue 3 (6-2017)
Abstract

Background: Cerebral arteriovenous malformations are rare congenital anomalies presenting as different symptoms depending on their size and the age of patient. Congestive heart failure is a rare condition in neonatal period and is most common due to structural heart defects, but rarely may be a result of peripheral shunts such as cerebral arteriovenous malformation.

Case presentation: A term male newborn infant who was delivered by Caesarean Section in Chamran Hospital, Ferdows, South Khorasan Province, June 2016. The infant was admitted to neonatal care unit due to nonreactive nonstress (NST) with normal Apgar score. In first postpartum visit, a systolic heart murmur was detected. Echocardiography showed small atrial septal defect secundum type and patent foramen ovale (PFO). He presented clinical manifestations of heart failure after 72 hours of birth. Antibiotic and treatment of heart failure was started. Following excluding most common etiologies of heart failure such as sepsis, anemia and arrhythmias, for detecting less common conditions such as cerebral vascular aneurism a transfontanelle ultrasonography was performed which showed dilated cerebral venous system. Magnetic resonance imaging (MRI) and Magnetic resonance venography (MRV) revealed a large congenital cerebral arterio-venous malformation (CAVM), in right cerebral hemisphere. Finally, he was expired 9 days after birth due to severe heart failure before any definitive treatment for closing CAVM could be done. 

Conclusion: CAVM are extremely rare vascular anomalies in newborns which may present occasionally as congestive heart failure in neonatal period. So after excluding other most common etiologies of heart failure such as structural heart defects, screening CAVMs should be done. Inspite of early diagnosis, usually they have extremely poor prognosis.

Evaluation of intravenous injection of amniotic membrane stem cells to reduce inflammatory factors in heart failure
Rojin Hemmati, Maryam Naseroleslami, Nahid Aboutaleb, Neda Mousavi Niri ,
Volume 79, Issue 5 (8-2021)
Abstract
Background: Heart failure is one of the most common cardiovascular disorders and is considered a chronic, progressive and debilitating disorder. The medical treatment of this disease is accompanied by many problems. Today, stem cells are being used increasingly to reduce the problems of heart failure treatments. Since pro-inflammatory cytokines play an important role in the prognosis and progression of cardiovascular disease, the present study aimed to investigate the effect of intravenous injection of human amniotic membrane mesenchymal stem cells on the levels of interleukins 4 and 12 in the serum of male rats in the heart failure model.
Methods: This is an experimental study that was conducted from October 2018 to May 2019 in the Physiology Research Center of Iran University of Medical Sciences. In this study, 28 male wistar rats (180-200 gr) were randomly divided into four groups: control group, heart failure group, heart failure group that received culture medium and heart failure group that received mesenchymal stem cells by intravenous injection. After 30 days, echocardiography was done and then serum levels of interleukin 4 and 12 were measured in these groups by Elisa test.
Results: The results of this study showed that intravenous injection of human amniotic membrane mesenchymal stem cells into male rats with heart failure, improved echocardiographic parameters such as ejection fraction (EF) and fractional shortening (FS) in the cell injection group compared to the heart failure group (P<0.05). Also, the levels of inflammatory cytokines IL-4 and IL-12 were significantly reduced in the cell injection group compared to rats with the heart failure group (P<0.05).
Conclusion: Due to the improvement of cardiac parameters and the reduction level of inflammatory cytokines in this study, it seems that human amniotic membrane mesenchymal stem cells play an important role in improving heart failure by reducing the level of inflammation.

The presence of atrioventricular accessory pathway can cause heart failure due to the disorder of cardiac depolarization sequence: a case report
Babak Payami, Shirin Azizidoost , Naem Mansouri ,
Volume 81, Issue 10 (1-2024)
Abstract
Background: Wolff-Parkinson-White syndrome is a rare but well-known disease that predisposes a person to cardiac arrhythmias. But sometimes this syndrome is accompanied by heart failure in the affected person. Several causes have been proposed for this complication including recurrent or incessant tachyarrhythmias that are frequently found in symptomatic (especially children) Wolf-Parkinson-White syndrome patients causing heart dysfunction and dilation and dilated cardiomyopathy, and also pre-excitation-related dyssynchrony leading to progressive ventricular remodeling and dilation. In this report, a patient is introduced who has improved his heart failure by radio-frequency ablation of free wall type of this syndrome.
Case Presentation: A 35-year-old man who had a history of Wolff-Parkinson-White syndrome from 8 years ago and suffered from dilatation and reduced left ventricular ejection fraction in recent years was presented with a pre-excited atrial fibrillation attack at the emergency department. The initial surface ECG showed positive delta wave in all precordial leads and negative QRS complexes in interior leads with QRS duration of about 200 ms. He had undergone electrophysiology study and ablation at the left postero-lateral accessory pathway. After ablation of accessory pathway within the months (from November 2022 until June 2023), left ventricular function was gradually improved and the symptoms of the patient's shortness of breath were also decreased.
Conclusion: The existence of heart failure in patients with Wolff-Parkinson-White syndrome can be due to various reasons including the presence of an accessory pathway and the dyssynchrony of intraventricular contraction which is caused by premature excitation of the connected part of the left ventricle by accessory atrioventricular pathway. Although in order to rule out the possibility of the incidental association of the accessory pathway with primary dilated cardiomyopathy and to investigate the segmental dyskinesia, it is necessary to perform diagnostic measures such as echocardiography and cardiac computerized tomography and magnetic resonance imaging, ablation of such accessory pathway not only controls arrhythmic attacks but also leads to the improvement of the left ventricular systolic function even in a middle age patient.

Investigation of risk factors for death in heart failure patients at Shahid Mustafa Khomeini Hospital
Firooz Balavandi, Hossein Moradkhani,
Volume 82, Issue 10 (1-2025)
Abstract
Background: Chronic heart failure (CHF) is a leading cause of cardiovascular mortality and hospitalization. Heart failure (HF) imposes both direct costs to healthcare systems and indirect costs to society through complications, unpaid care costs, premature mortality, and loss of productivity. The aim of the present study was to investigate the quality of care, laboratory and clinical indicators affecting mortality in heart failure patients.
Methods: In a descriptive study conducted in the summer of 1402, data were collected by extracting the list of patients who died with a diagnosis of heart failure from the hospital's information management system, based on random sampling, and recorded in a checklist. The number of patients selected was from a study of factors affecting mortality in heart failure patients at Shahid Mustafa Khomeini Hospital.
Results: 25.8% of patients had bilateral rales on pulmonary auscultation, and 88.7% of them reported shortness of breath, 58.1% edema, and 22.6% chest pain. LVEF of most patients was 10-25. With a decrease in systolic blood pressure and an increase in diastolic and HR, the probability of mortality increased significantly (1.058, 0.932, and 0.983) times, respectively. With a decrease in oxygen level, the probability of mortality increased significantly by 0.983 times. The mean ALT and AST increased significantly and the mean HCT also decreased significantly. With each unit increase in ALT and AST and each unit decrease in Hct, the probability of mortality increased (1.008, 0.985 and 1.283) times, respectively. With the decrease in Hb and FBS and the increase in Cr and BUN, the probability of mortality increased by 0.314, 1.013, 1.884 and 0.969 times, respectively. However, no significant relationship was observed between mortality and the factors Hb, FBS, Cr and BUN with patient mortality.
Conclusion: Dyspnea and edema were common in patients, and bilateral rales and chest pain were observed in less than half of the patients. A decrease in systolic blood pressure and an increase in diastolic and HR significantly increased the probability of mortality. A decrease in oxygen levels also significantly increased mortality in patients.

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