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Showing 6 results for Hepatitis C
Prevalence of oral lichen planus in HCV infected patients: the effective factors
Khatibi M, Ahmadinejad Z, Nasiri-Toosi M, Hajibaygi B, Zahedipour H,
Volume 66, Issue 8 (11-2008)
Abstract

Background: Hepatitis C is a major cause of chronic liver disease and hepatocellular carcinoma. Hepatitis C infection also has extrahepatic manifestations, including cryoglobulinemia and lichen planus. Lichen planus is a relatively common mucocutaneous disorder, and, due to its chronic pattern and increased incidence of malignancy, diagnosis and treatment of this disease are very important. The aim of the present study was to investigate the prevalence of oral lichen planus in HCV-infected patients.

Methods: In this cross sectional- descriptive study, the prevalence of oral lichen planus was evaluated by means of observation, clinical examination, questionnaire and evaluation of the medical records of 150 patients referred to the hepatitis clinic, gastrointentrology and infectious disease wards of Imam Khomeini Hospital and the Iran Blood Transfusion Organization, Tehran, Iran. We used a sequential method for sampling. Data were analyzed using statistical software (SPSS ver. 11) and the chi-square test.

Results: From a total 150 patients, 133 were male and 17 female. Six cases (4%) had oral lichen planus. All patients with oral lichen planus were male and the buccal mucosa was the most common site.

Conclusions: According to this study, the prevalence of oral lichen planus in patients afflicted with HCV is higher than in the normal population. We should pay more attention to oral lichen planus as one of the extrahepatic manifestations of hepatitis C.


Seroprevalence of Hepatitis C (HCV) and Human Immunodeficiency Virus (HIV) infection among street children in Isfahan, Iran
Ataei B, Nokhodian Z, Babak A, Shoaei P, Mohhammadzadeh M, Sadeghi R,
Volume 67, Issue 11 (2-2010)
Abstract

Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Background: There are millions of children around the world living on the street. They are at higher risk of physical, sexual and drug abuse, and have no access to health care facilities. Therefore they are at risk of viral infections such as HCV and HIV. The aim of this study was determining the prevalence of HCV and HIV infection in Isfahan street children (2005-2007).
Methods: The cross-sectional study was taken place on 386 street children through a nonprobable-convenience sampling method. They were requested to answer a questionnaire (demographic and behavioral data), and then they were tested for anti HCV and anti HIV antibodies.
Results: Among 386 street children, 270 (70%) were boys and the mean age was 12.62±3.23 years. The majority of them, 267 cases (69%), were on the street for financial reasons. 353 (91.7%), 366 (94.8%) and 375 (97.2%) of them had no history of smoking, using alcohol or substance addiction, respectively. 40 (34.5%) of girls and 12 (4.4%) of boys (p<0.0001) were engaged in sex and 79 (68%) of girls and 46 (17%) of boys (p<0.0001) were involved in physical fighting. All of the children had negative serology for HIV infection. Nevertheless, four of them (1%) were positive for HCV Ab.
Conclusion: The knowledge of street children about high risk behaviors and the infectious diseases should be improved through educational programs. They need also legal, social and health support.


Investigating the presence of different hepatitis C virus genotypes in serum, peripheral blood mononuclear cells, and liver biopsy specimens of patients with hepatitis C virus infection
Bokharaei-Salim F, Keyvani H, Zamani F, Jahanbakhsh Sefidi F, Amiri A,
Volume 69, Issue 10 (1-2012)
Abstract

Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Background: Hepatitis C virus (HCV) is essentially considered as hepatotropic, but virus sequences have also been found in other important extrahepatic sites, including peripheral blood mononuclear cells (PBMCs). This study was done to investigate the presence of mixed infection and the differences between hepatitis C virus genotypes in plasma, peripheral blood mononuclear cells, and liver biopsy specimens in patients with hepatitis C virus infection.
Methods : One hundred and fifty two patients with established chronic hepatitis C infection attending Firouzgar Hospital, affiliated to Tehran University of Medical Sciences, from September 2008 to April 2010 were enrolled in the present study. After collecting plasma, peripheral blood mononuclear cell, and liver biopsy specimens, RNA was extracted from the samples and hepatitis C virus genotyping was performed using INNO-LiPATM HCV II kit. The hepatitis C virus genotyping was confirmed by sequencing the RT-nested PCR product of 5'-UTR fragments.
Results : The mean age of the participants was 31.2±16.9 years. Multiple hepatitis C virus genotypes were detected in 4 (2.6%) out of 152 plasma samples, 10 (6.6%) out of 152 peripheral blood mononuclear cell samples, and 9 (18.8%) out of 48 liver biopsy specimens. Hepatitis C virus genotypes were different in the plasma, PBMC, and liver biopsy specimens of 21 (13.8%) patients.
Conclusion: The present study shows that a significant proportion of patients with chronic hepatitis C infection are infected by multiple hepatitis C virus genotypes which may not be detectable in their plasma specimens.


Comparison of hepatitis C virus risk factors in genotypes 1a and 3a
Mansour Bahardoust, Shahram Agah , Arash Sarveazad , Amir Hossein Faghihi , Asrin Babahajian , Seyed Ali Hashemi Kiapay , Farnaz Farsi , Marjan Mokhtare,
Volume 76, Issue 3 (6-2018)
Abstract
Background: One of the most important causes of chronic liver disease is hepatitis C virus (HCV), which causes liver cirrhosis and hepatocellular carcinoma. To control the prevalence of the disease, knowledge and information in risk factor of HCV are required. The aim of this study was to compare the risk factors of infection between HCV patients with genotypes 1a and 3a.
Methods: This is an observational analytical study. HCV patients who referred to the clinic of hepatology, Rasoul-e-Akram University Hospital from July 2015 to July 2017, were assigned to the genotype 1a and 3a. Demographic (age, sex, family history), clinical (cirrhosis, hepatocellular carcinoma) and laboratory data, history of intravenous drug and alcohol usage, and history of imprisonment were gathered and compared between two groups. All the patients completed the informed consent form. Data analysis was performed by SPSS software, version 22 (IBM SPSS, Armonk, NY, USA). P value less than 0.05 was considered statistically significant.
Results: Overall, 97 HCV patients were included in this study. Mean age was 45±12 years and 78 (80%) of patients were male. Among them, 58 (60%) and 39 (40%) had genotype 1a and 3a. respectively. History of injection drug usage was recorded in 34/39 (87%) of patients with genotype 3a, and significantly higher in genotype 3a as compared to genotype 1a [OR adj: 3.1, CI (1.3-6.2)]. Also, in this study, genotype 3a was significantly recorded in younger patients [OR adj: 1.7, CI (1.2-4.1)]. However, cirrhosis and hepatocellular carcinoma was more common in patients with genotype 1a as compared to genotype 3a [OR adj: 2.05, CI (1.6-5.4) and OR adj: 2.8, CI (1.3-5.7)] respectively.
Conclusion: According to the results of this study, hepatitis C virus transmission risk factors differed in genotypes 3a and 1a. Genotype 3a is found among young patients with a history of intravenous drug usage and genotype 1a in patients with cirrhosis and hepatocellular carcinoma.

Quality of life and health-related quality of life in hepatitis C patients and B patients
Mansour Bahardoust, Marjan Mokhtare , Arezoo Chaharmahali , Fatemeh Mousazadeh , Shahram Agah ,
Volume 77, Issue 3 (6-2019)
Abstract
Background: Psychosocial issues and quality of life are important components at the patients diagnosed with chronic hepatitis B and C. Hepatitis is a chronic liver disease that can affect quality of life of patients. In this study, we compared the quality of life between patients with hepatitis B and C and finally presented a structural model about it.
Methods: In a prospective analytic study, 86 patients with hepatitis B and 86 with hepatitis C who referred to the Rasoul-e-Akram Hospital in Tehran from April 2015 to April 2018 were compared regarding the quality of life and health-related quality of life. The clinical and radiographic data of patients were extracted from their medical records. The 36-item short-form health survey (SF-36) was used for the evaluation quality of life and health-related quality of life. The questionnaire consisted of 36 questions in eight sub-scales (physical performance, physical role, physical pain, general health, vitality, social role, emotional role, and mental health).
Results: Generally, the quality of life score was significantly lower in patients with hepatitis C (34.13±9.37) than patients with hepatitis B (51.5±10.5) (P=0.001). Except for the physical role and vitality, all other SF-36 subscales were significantly lower in the HCV patients group (P>0.05). Based on the results of logistic regression, the emotional dimension of patients was reported as most important effect on the quality of life in patients [(OR=9.15, 95% CI=(4.11-15.41), P=0.001)]. Based on the results of linear analysis, hepatitis type [(B=4.21, P=0.001)], patient income [(B=2.57, P=0.001)], the level of education [(B=2.9, P=0.014)] and the gender of patients [(B=2.77, P=0.023)] were reported as most important factors affecting the quality of life of patients, respectively. There was no significant difference between age, body mass index and smoking reported in patients' quality of life (P>0.05).
Conclusion: According to the results of this study, the quality of life in patients with hepatitis C was significantly lower than the quality of life in patients with hepatitis B.

Association between ABO blood group and hepatitis B and C infection
Mansour Bahardoust, Marjan Mokhtare , Shahram Agah ,
Volume 77, Issue 5 (8-2019)
Abstract
Background: Hepatitis is among the major health problems, especially in developing countries. During past decades, the association between type of blood group (ABO) and hepatitis B and C virus has always been discussed. This study was designed to investigate the possible association between type of ABO blood group and chronic hepatitis B and C infection.
Methods: In the present analytical study, frequency of blood groups and their relationship with hepatitis B and C were evaluated in three groups: group A (patients with hepatitis B), group B (patients with hepatitis C) and group control (subjects with non-hepatitis B and C). The study was done from October 2016 to October 2018 on patients who referred to Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. Demographic and laboratory data of all participants were extracted and collected from their medical records.
Results: Overall, 196 and 103 patients in group A, B and three hundred control were included in this study, respectively. The baseline demographic data of patients were not significantly different between treatment groups. The mean age of participants was 35.1±13 years. The O blood group was significantly higher in patients with hepatitis B (46.4%) and hepatitis C (41.9%) compared to control group (34%) (P=0.001). The risk of hepatitis B and C infection were significantly higher among patients with O blood group (OR = 3.9, 95% CI 2.1-5.9; P = 0.001) and (OR = 2.7, 95% CI 1.7-5.6; P = 0.02), respectively] while, the risk of hepatitis B infection was significantly lesser in participants with blood group A (OR = 0.4, 95% CI -1.2-0.8). Rh positive participants significantly were at higher risk of hepatitis (B and C) than Rh negative participants. (P<0.05).
Conclusion: Participants with blood group O were at higher risk for chronic hepatitis B and C B infection and antigen (Rh) positive. Hepatitis B infection was reported lesser in participants with blood group A.

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