Refahi R, Rahbani M, Afrasiabi A, Refahi S,
Volume 63, Issue 4 (7-2005)
Abstract
Background: The aim of the study is to evaluate correlation between hyperhomocysteinemia and oxidative stress with severity of atherosclerosis lesions.
Materials and Methods: The patients (52 males and 36 females) were selected from individuals with angiographically defined CAD admitted to the shahid Madani Hospital. Control groups were selected from sex and age matched apparently healthy individuals (15 Males and 24 Females). Serum Homocysteine levles were measured by ELISA method (Awareness stat fax-2100 Model). Total antionxidant capacity of samples was determined by Autoanalyzer (COBAS MIRA plus model) using Randox kits. The correlation between the measured parameters and extension of atherosclerotic lesions were calculated using statistical analysis in the both groups.
Results: The mean levels of Homocysteine in patients and control groups were 20.38 ± 10.22 μmol/l and 18.56 ± 9.47 μmol/L respectively and the differences were not significant (p> 0.05) . In the patient group the mean level of Antioxidant capacity was 1.34 ± 0.12 mmol/L. whereas that of control was 1.39 ± 0.12 mmol/L (p>0.05). Using statistical analysis no correlation was noticed between extension of atherosclerosis lesions٫ low total antioxidant capacity and high serum total homocysteine .
Conclusion: In this study no significant differences between levels of homocysteine and total antioxidant in patients and control groups and no marked relationship between studied parameters suggest, that hyperhomocysteinemia has no important role in progress of atherosclerosis lesions.
Reza Afghani , Ali Aminian , Seyed Rasoul Mirsharifi, Ali Jafarian , Hamid Ghaderi , Morteza Noaparast , Seyed Habibollah Dashti ,
Volume 68, Issue 8 (11-2010)
Abstract
Background: Gall stone is an important health problem in the world for which different risk factors have been characterized. Gall stone and cardiovascular disease have common risk factors. Homocysteine is accepted as one of the risk factors for cardiovascular disease. We aimed to study the effect of homocysteine level on gall stone formation.
Methods: 54 patients with gall stone-related diseases and 54 patients without stone (control group) were studied from January 2007 to December 2008. Control group consisted healthy subjects with ultrasound proven normal gallbladder. Serum homocysteine level was checked in both groups. Homocysteine level of equal or more than 15 mmol/l was considered as abnormally high.
Results: Cases included 43 women (79.6%) and had mean age of 50.76±15.23 years. Homocysteine level was significantly higher in patients with gallstone in comparison to control group (p=0.014). Risk of gall stone increased 3.4 times in persons who have homocysteine level equal or greater than 15mmol/l (p=0.019). The mean level of homocysteine was higher in men than women (p=0.03). The mean level of homocysteine did not differ significantly in patients with simple gallstone and patients with gallstone-related inflammation disorders (cholecystitis, cholangitis, and pancreatitis). Additionally, one unit increase in BMI level was associated with 1.12 times increase in the risk for gall stone formation (p=0.035).
Conclusion: The homocysteine level is increased in patients with gall stone-related diseases. Homocysteine may be considered as a risk factor of gall stone formation.
