Ghasemi A, Jahanlou A, Hamdi K, Rezaei A,
Volume 69, Issue 4 (7-2011)
Abstract
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Background: Intrauterine insemination (IUI) is a less expensive
and less invasive treatment in comparison with other assisted reproductive
techniques, and it has been widely used for a variety of indications as well as
in the treatment of couples with infertility. The outcome of IUI
may be affected by numerous factors but in this study, we evaluated the effects
of cervical mucus removal undertaken before IUI
on clinical pregnancy rates.
Methods : In this randomized clinical trial study, all infertile women who were
candidates for IUI and attended Shahid
Akbar Abadi Hospital during 2009 and 2010
were recruited. The participants were randomly assigned into two groups. Cervical
mucus was removed prior to IUI in patients in group
A but in group B,
a classic IUI was done without removing
the cervical mucus. Pregnancy rates were assessed in the two groups by serum
levels of β-HCG
and detection of fetus in the uterus.
Results : 291 women including 143
in the classic IUI group and 148
in cervical mucus removal group completed the study. The pregnancy rates were 14.2%
(21 pregnancies upon 148
cycles) in the cervical mucus removal group and 7% (10
pregnancies upon 143 cycles) in the
control group (P=0.04, OR: 2.199 CI 95%: 0.997-4.85).
Conclusion: The
findings showed that cervical mucus removal could result in a two-fold increase
in pregnancy rate in comparison with classic IUI.
Thus, we suggest this practical and noninvasive method to improve pregnancy
rate in these patients.
Marjan Sabbaghian, Tahereh Modarresi, Hani Hosseinifar, Ali Daliri Hampa, Leila Karimian, Firoozeh Ghaffari, Jalil Hosseini, Mohammad Ali Sadighi Gilani,
Volume 71, Issue 8 (11-2013)
Abstract
Background: Intrauterine insemination (IUI) is one the most common methods in infertility treatment, but its efficiency in infertile couples with male factor is controversial. This study is a retrospective study about correlation between semen parameters and male and female age with successful rate of IUI in patients attending to Royan Institute.
Methods: A total of 998 consecutive couples in a period of 6 months undergoing IUI were included. They were classified into two groups: couples with successful and unsuccessful pregnancy. Main outcome was clinical pregnancy. Data about male and female ages and semen analysis including concentration, total sperm motility, class A motility, class B motility, class A+B motility and normal morphology was extracted from patients’ records. Semen samples were collected by masturbation or coitus after 2 to 7 days of abstinence. Their female partners were reported to have no chronic medi-cal conditions and have normal menstrual cycles.
Results: One hundred and fifty seven of total 998 cycles (15.7%) achieved pregnancy. The average of female age in successful and unsuccessful group was 28.95±4.19 and 30.00±4.56 years, respectively. Mean of male age was 33.97±4.85 years in successful group and 34.44±4.62 years in unsuccessful group. In successful and unsuccessful groups, average of sperm concentration was 53.62±38.45 and 46.26±26.59 (million sperm/ml), normal morphology of sperm was 8.98±4.31 (%) and 8.68±4.81 (%), sperm total motility was 47.24±18.92 (%) and 43.70±20.22 (%) and total motile sperm count was 80.10±63.61 million and 78.57±68.22 million, respectively.
Conclusion: There was no significant difference in mean of females’ age and males’ age between successful and unsuccessful groups (P<0.05). In addition, there was no significant difference in semen parameters including concentration, total sperm motility, class A motility, class B motility, class A+B motility and normal morphology between two groups. It was shown that common semen analysis and male and female ages cannot predict IUI outcome.
Shahideh Jahanian Sadatmahalleh, Firouzeh Ghaffari, Mohammad Reza Akhoond ,
Volume 78, Issue 11 (2-2021)
Abstract
Background: Common treatment for infertile couples is the use of controlled ovulation hyperstimulation (COH) with intrauterine inseminations (IUI). IUI is used in cases such as ovulatory dysfunction, cervical factor infertility, male subfertility, and unexplained infertility. In this study, we evaluated the relationship between IUI outcome and special causes of infertility.
Methods: This was a cross-sectional study and a sampling method was available in this study, from January 2014 to August 2016, 994 cycles in 803 infertile couples referred to Royan Research Institute in Tehran were analyzed. Inclusion criteria were: male factor infertility, combined causes, ovarian disease, and infertility of unknown cause. To evaluate pregnancy, 12-16 days after IUI, it was considered positive if pregnancy test followed by transvaginal ultrasound at week 4 after IUI were positive.
Data were analyzed using SPSS software, version 20. T-test and chi-square were used to compare the case and control groups. Linear-by-linear test was also used to calculate the relationship between female age and clinical and multiple success rates. P<0.05 was considered significant for the results of these tests.
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Results: The success rate of pregnancy in all cycles (16.5%) and live birth rate per cycle (14.5%) were calculated. The mean age in the pregnant group was significantly lower than that of the non-pregnant group (P = 0.01). Our findings were: Infertility with unknown cause (290 people, 29.2%), male factor (395 people, 39.7%), ovulation disorders (201 people, 20.2%) [which include: decreased ovarian reserve (1 person) 0.5%), polycystic ovary syndrome (188 patients, 93.5%) and hypothalamic amenorrhea (12 patients, 6%)] and a combination of different factors (108 patients, 10.9%). There was also a significant relationship between the cause of infertility and clinical pregnancies (P<0.001). A Significant decrease in pregnancy success rate was observed with increasing infertility duration (OR=0.8, CI=0.8-0.9, P<0.001).
Conclusion: Women’s age, etiology of infertility, duration of infertility, irregular menstruation, semen volume, and gonadotropin dose were important factors in COH+IUI cycles.
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